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Science 22 December 1989:
Vol. 246. no. 4937, pp. 1629 - 1632
DOI: 10.1126/science.2531920
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Articles

Science, Vol 246, Issue 4937, 1629-1632
Copyright © 1989 by American Association for the Advancement of Science

articles

Differential effects of nef on HIV replication: implications for viral pathogenesis in the host

C Cheng-Mayer, P Iannello, K Shaw, PA Luciw, and JA Levy

Department of Medicine, University of California, San Francisco 94143.

Stable lymphoid cell lines expressing the human immunodeficiency virus type 1 (HIV-1) nef gene product, p27, were established. The presence of p27 in the lymphoid cells suppressed replication of some strains of both HIV-1 and HIV-2. This observation indicates that nef could be important in the establishment of HIV latency. In contrast, fast replicating and highly cytopathic HIV-1 isolates recovered from patients with advanced disease states were not affected by the negative effect of nef present in these lymphoid cell lines. This lack of response to nef appears to constitute another viral feature that correlates with disease progression. Thus, manipulating expression of the nef gene in vivo might influence pathogenesis in the host.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking Pathways.
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Genetic and Functional Diversity of Human Immunodeficiency Virus Type 1 Subtype B Nef Primary Isolates.
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Mechanisms of HIV-associated lymphocyte apoptosis.
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Vaccine effect using a live attenuated nef-deficient simian immunodeficiency virus of African green monkeys in the absence of detectable vaccine virus replication in vivo.
B. Beer, M. Baier, J. zur Megede, S. Norley, and R. Kurth (1997)
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Physical and Functional Interaction of Nef with Lck.
Y. Collette, H. Dutartre, A. Benziane, F. Ramos-Morales, R. Benarous, M. Harris, and D. Olive (1996)
J. Biol. Chem. 271, 6333-6341
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A Conserved Domain and Membrane Targeting of Nef from HIV and SIV Are Required for Association with a Cellular Serine Kinase Activity.
E. T. Sawai, A. S. Baur, B. M. Peterlin, J. A. Levy, and C. Cheng-Mayer (1995)
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Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques.
T. Baba, Y. Jeong, D Pennick, R Bronson, M. Greene, and R. Ruprecht (1995)
Science 267, 1820-1825
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Molecular targets for AIDS therapy.
H Mitsuya, R Yarchoan, and S Broder (1990)
Science 249, 1533-1544
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