Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 December 1989:
Vol. 246. no. 4937, pp. 1622 - 1625
DOI: 10.1126/science.2512642
Prev | Table of Contents | Next

Articles

Science, Vol 246, Issue 4937, 1622-1625
Copyright © 1989 by American Association for the Advancement of Science

articles

Regulation of proenkephalin by Fos and Jun

JL Sonnenberg, FJ Rauscher 3rd, JI Morgan, and T Curran

Department of Molecular Oncology, Molecular Biology, Roche Research Center, Nutley, NJ 07110.

Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site. Although this complex has been proposed to function as a transcriptional regulator in neurons, no specific target gene has yet been identified. Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c-fos and c-jun expression was detected. Fos-Jun complexes bound specifically to a regulatory sequence in the 5' control region of the proenkephalin gene. Furthermore, c-fos and c-jun stimulated transcription from this control region synergistically in transactivation assays. These data suggest that the proenkephalin gene may be a physiological target for Fos and Jun in the hippocampus and indicate that these proto-oncogene transcription factors may play a role in neuronal responses to stimulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Somatic Excision Demonstrates that c-Jun Induces Cellular Migration and Invasion through Induction of Stem Cell Factor.
S. Katiyar, X. Jiao, E. Wagner, M. P. Lisanti, and R. G. Pestell (2007)
Mol. Cell. Biol. 27, 1356-1369
   Abstract »    Full Text »    PDF »
The Effects of a Selective Dopamine D2 Receptor Agonist on Behavioral and Pathological Outcome in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Squirrel Monkeys.
D. T. Stephenson, M. D. Meglasson, M. A. Connell, M. A. Childs, E. Hajos-Korcsok, and M. E. Emborg (2005)
J. Pharmacol. Exp. Ther. 314, 1257-1266
   Abstract »    Full Text »    PDF »
Simvastatin Augments Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages by Differential Regulation of the c-Fos and c-Jun Transcription Factors.
M. Matsumoto, D. Einhaus, E. S. Gold, and A. Aderem (2004)
J. Immunol. 172, 7377-7384
   Abstract »    Full Text »    PDF »
A Calcium-Initiated Signaling Pathway Propagated through Calcineurin and cAMP Response Element-Binding Protein Activates Proenkephalin Gene Transcription after Depolarization.
S. H. Hahm, Y. Chen, C. Vinson, and L. E. Eiden (2003)
Mol. Pharmacol. 64, 1503-1511
   Abstract »    Full Text »    PDF »
Midazolam Induces Expression of c-Fos and EGR-1 by a Non-GABAergic Mechanism.
K. Fukuda, T. Shoda, H. Mima, and H. Uga (2002)
Anesth. Analg. 95, 373-378
   Abstract »    Full Text »    PDF »
Cycloheximide Increases Proenkephalin and Tyrosine Hydroxylase Gene Expression in Rat Adrenal Medulla.
J.-S. Won, J.-K. Lee, D.-K. Song, S.-O. Huh, J.-S. Jung, Y.-H. Kim, M.-R. Choi, and H.-W. Suh (2000)
Mol. Pharmacol. 57, 1173-1181
   Abstract »    Full Text »
Changes in Activating Protein 1 (AP-1) Composition Correspond with the Biphasic Profile of Nerve Growth Factor mRNA Expression in Rat Hippocampus after Hilus Lesion-Induced Seizures.
R. C. Elliott and C. M. Gall (2000)
J. Neurosci. 20, 2142-2149
   Abstract »    Full Text »    PDF »
c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation.
F. Cong and S. P. Goff (1999)
PNAS 96, 13819-13824
   Abstract »    Full Text »    PDF »
Both Inducible and Constitutive Activator Protein-1-Like Transcription Factors Are Used for Transcriptional Activation of the Galanin Gene by Different First and Second Messenger Pathways.
Y. Anouar, H.-W. Lee, and L. E. Eiden (1999)
Mol. Pharmacol. 56, 162-169
   Abstract »    Full Text »
Neocortical Projections Regulate the Neostriatal Proenkephalin Gene Expression.
L. Just, C. Olenik, and D.K. Meyer (1999)
Cereb Cortex 9, 332-339
   Abstract »    Full Text »    PDF »
Potential Role of the Gene Transcription Factor Cyclic AMP-Responsive Element Binding Protein in Ethanol Withdrawal-Related Anxiety.
S. C. Pandey, D. Zhang, N. Mittal, and D. Nayyar (1999)
J. Pharmacol. Exp. Ther. 288, 866-878
   Abstract »    Full Text »
Estradiol Sensitization of Rat Pituitary Cells to Gonadotropin-Releasing Hormone: Involvement of Protein Kinase C- and Calcium-Dependent Signaling Pathways.
I. M. Colin and J. L. Jameson (1998)
Endocrinology 139, 3796-3802
   Abstract »    Full Text »    PDF »
Dominant Negative Regulation by c-Jun of Transcription of the Uncoupling Protein-1 Gene through a Proximal cAMP-Regulatory Element: A Mechanism for Repressing Basal and Norepinephrine-Induced Expression of the Gene before Brown Adipocyte Differentiation.
P. Yubero, M. Barberá, R. Alvarez, O. Viñas, T. Mampel, R. Iglesias, F. Villarroya, and M. Giralt (1998)
Mol. Endocrinol. 12, 1023-1037
   Abstract »    Full Text »
A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year.
G. Bing, B. Wilson, P. Hudson, L. Jin, Z. Feng, W. Zhang, R. Bing, and J.-S. Hong (1997)
PNAS 94, 9422-9427
   Abstract »    Full Text »    PDF »
Two Proximal Activating Protein-1-Binding Sites Are Sufficient to Stimulate Transcription of the Ovine Follicle-Stimulating Hormone-{beta} Gene.
B. D. Strahl, H.-J. Huang, N. R. Pedersen, J. C. Wu, B. R. Ghosh, and W. L. Miller (1997)
Endocrinology 138, 2621-2631
   Abstract »    Full Text »    PDF »
Cortically Driven Immediate-Early Gene Expression Reflects Modular Influence of Sensorimotor Cortex on Identified Striatal Neurons in the Squirrel Monkey.
H.B. Parthasarathy and A.M. Graybiel (1997)
J. Neurosci. 17, 2477-2491
   Abstract »    Full Text »    PDF »
Thapsigargin-Induced Gene Expression in Nonexcitable Cells Is Dependent on Calcium Influx.
K. D. Rodland, R. P. Wersto, S. Hobson, and E. C. Kohn (1997)
Mol. Endocrinol. 11, 281-291
   Abstract »    Full Text »
Toward a molecular definition of long-term memory storage.
C. H. Bailey, D. Bartsch, and E. R. Kandel (1996)
PNAS 93, 13445-13452
   Abstract »    Full Text »    PDF »
REVIEW {blacksquare} : Jun, Fos, and CREB/ATF Transcription Factors in the Brain: Control of Gene Expression under Normal and Pathophysiological Conditions.
T. Herdegen (1996)
Neuroscientist 2, 153-161
   Abstract »    PDF »
A Consensus Insulin Response Element Is Activated by an ETS-related Transcription Factor.
K. K. Jacob, L. Ouyang, and F. M. Stanley (1995)
J. Biol. Chem. 270, 27773-27779
   Abstract »    Full Text »    PDF »
Inducible Proto-oncogene Transcription Factors: Third Messengers in the Brain?.
T. Curran, C. Abate, D.R. Cohen, P.F. Macgregor, F.J. Rauscher III, J.L. Sonnenberg, J.A. Connor, and J.I. Morgan (1990)
Cold Spring Harb Symp Quant Biol 55, 225-234
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)