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Science 22 December 1989:
Vol. 246. no. 4937, pp. 1614 - 1617
DOI: 10.1126/science.2480643
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Articles

Science, Vol 246, Issue 4937, 1614-1617
Copyright © 1989 by American Association for the Advancement of Science

articles

Immunodeficiency and clonal growth of target cells induced by helper-free defective retrovirus

M Huang, C Simard, and P Jolicoeur

Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada.

The murine acquired immunodeficiency syndrome is induced by a defective retrovirus. To study the role of virus replication in this disease, helper-free stocks of defective Duplan virus were produced. These stocks were highly pathogenic in absence of detectable replicating murine leukemia viruses (MuLVs) other than xenotropic MuLV. They induced expansion of the infected cell population (over 1000-fold), and this cell expansion was oligoclonal in origin and, most likely, arose through cell division. These results suggest that this defective virus is oncogenic, inducing a primary neoplasia associated with an acquired immunodeficiency syndrome as a paraneoplastic syndrome. These data emphasize the need to determine whether virus replication is necessary for the progression of other immunodeficiency diseases, including acquired immunodeficiency syndrome, and whether these diseases also represent paraneoplastic syndromes.


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