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Science 22 December 1989:
Vol. 246. no. 4937, pp. 1601 - 1603
DOI: 10.1126/science.2688092
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Articles

Science, Vol 246, Issue 4937, 1601-1603
Copyright © 1989 by American Association for the Advancement of Science

articles

Endothelial interleukin-8: a novel inhibitor of leukocyte-endothelial interactions

MA Gimbrone Jr, MS Obin, AF Brock, EA Luis, PE Hass, CA Hebert, YK Yip, DW Leung, DG Lowe, WJ Kohr, and al. et

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

Certain inflammatory stimuli render cultured human vascular endothelial cells hyperadhesive for neutrophils. This state is transient and reversible, in part because activated endothelial cells secrete a leukocyte adhesion inhibitor (LAI). LAI was identified as endothelial interleukin-8 (IL-8), the predominant species of which is an extended amino-terminal IL-8 variant. At nanomolar concentrations, purified endothelial IL-8 and recombinant human IL-8 inhibit neutrophil adhesion to cytokine-activated endothelial monolayers and protect these monolayers from neutrophil-mediated damage. These findings suggest that endothelial-derived IL-8 may function to attenuate inflammatory events at the interface between vessel wall and blood.


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