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Science 8 December 1989:
Vol. 246. no. 4935, pp. 1303 - 1306
DOI: 10.1126/science.2588007
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Articles

Science, Vol 246, Issue 4935, 1303-1306
Copyright © 1989 by American Association for the Advancement of Science

articles

An inducible endothelial cell surface glycoprotein mediates melanoma adhesion

GE Rice and MP Bevilacqua

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

Hematogenous metastasis requires the arrest and extravasation of blood-borne tumor cells, possibly involving direct adhesive interactions with vascular endothelium. Cytokine activation of cultured human endothelium increases adhesion of melanoma and carcinoma cell lines. An inducible 110-kD endothelial cell surface glycoprotein, designated INCAM-110, appears to mediate adhesion of melanoma cells. In addition, an inducible endothelial receptor for neutrophils, ELAM-1, supports the adhesion of a human colon carcinoma cell line. Thus, activation of vascular endothelium in vivo that results in increased expression of INCAM-110 and ELAM-1 may promote tumor cell adhesion and affect the incidence and distribution of metastases.


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