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Science 24 November 1989:
Vol. 246. no. 4933, pp. 1044 - 1046
DOI: 10.1126/science.2511630
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Articles

Science, Vol 246, Issue 4933, 1044-1046
Copyright © 1989 by American Association for the Advancement of Science

articles

Thymic requirement for clonal deletion during T cell development

AM Fry, LA Jones, AM Kruisbeek, and LA Matis

Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892.

During T cell differentiation, self tolerance is established in part by the deletion of self-reactive T cells within the thymus (negative selection). The presence of T cell receptor (TCR)-alpha beta + T cells in older athymic (nu/nu) mice indicates that some T cells can also mature without thymic influence. Therefore, to determine whether the thymus is required for negative selection, TCR V beta expression was compared in athymic nu/nu mice and their congenic normal littermates. T cells expressing V beta 3 proteins are specific for minor lymphocyte stimulatory (Mlsc) determinants and are deleted intrathymically due to self tolerance in Mlsc+ mouse strains. Here it is shown that V beta 3+ T cells are deleted in Mlsc+ BALB/c nu/+ mice, but not in their BALB/c nu/nu littermates. Thus, the thymus is required for clonal deletion during T cell development.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)