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Science 17 November 1989:
Vol. 246. no. 4932, pp. 919 - 922
DOI: 10.1126/science.2814514
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Articles
Science, Vol 246, Issue 4932, 919-922
Copyright © 1989 by American Association for the Advancement of Science
Molecular mechanisms and forces involved in the adhesion and fusion of amphiphilic bilayers
CA Helm,
JN Israelachvili,
and
PM McGuiggan
Department of Chemical and Nuclear Engineering, University of California, Santa Barbara 93106.
The surface forces apparatus technique was used for measuring the adhesion, deformation, and fusion of bilayers supported on mica surfaces in aqueous solutions. The most important force leading to the direct fusion of bilayers is the hydrophobic interaction, although the occurrence of fusion is not simply related to the force law between bilayers. Bilayers do not need to "overcome" some repulsive force barrier, such as hydration, before they can fuse. Instead, once bilayer surfaces come within about 1 nanometer of each other, local deformations and molecular rearrangements allow them to "bypass" these forces.
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