Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 November 1989:
Vol. 246. no. 4930, pp. 622 - 628
DOI: 10.1126/science.2683078
Prev | Table of Contents | Next

Articles

Science, Vol 246, Issue 4930, 622-628
Copyright © 1989 by American Association for the Advancement of Science

articles

Mitosis

McIntosh JR and MP Koonce

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309.

Data that describe both the structure and the physiology of the mitotic spindle are reviewed. Some of the molecules that have been shown to play a role in mitosis are tabulated, and how mitosis might work is considered.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice..
R. Aneja, J. Zhou, B. Zhou, R. Chandra, and H. C. Joshi (2006)
Mol. Cancer Ther. 5, 2366-2377
   Abstract »    Full Text »    PDF »
Multiple mechanisms regulate NuMA dynamics at spindle poles.
O. Kisurina-Evgenieva, G. Mack, Q. Du, I. Macara, A. Khodjakov, and D. A. Compton (2004)
J. Cell Sci. 117, 6391-6400
   Abstract »    Full Text »    PDF »
The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.
N. J. Ganem and D. A. Compton (2004)
J. Cell Biol. 166, 473-478
   Abstract »    Full Text »    PDF »
A Mechanistic Model for the Organization of Microtubule Asters by Motor and Non-Motor Proteins in a Mammalian Mitotic Extract.
A. Chakravarty, L. Howard, and D. A. Compton (2004)
Mol. Biol. Cell 15, 2116-2132
   Abstract »    Full Text »    PDF »
Chfr Regulates a Mitotic Stress Pathway through its RING-Finger Domain with Ubiquitin Ligase Activity.
P. Chaturvedi, V. Sudakin, M. L. Bobiak, P. W. Fisher, M. R. Mattern, S. A. Jablonski, M. R. Hurle, Y. Zhu, T. J. Yen, and B.-B. S. Zhou (2002)
Cancer Res. 62, 1797-1801
   Abstract »    Full Text »    PDF »
Chromosome Movement in Mitosis Requires Microtubule Anchorage at Spindle Poles.
M. B. Gordon, L. Howard, and D. A. Compton (2001)
J. Cell Biol. 152, 425-434
   Abstract »    Full Text »    PDF »
Dynamics of Transitional Endoplasmic Reticulum Sites in Vertebrate Cells.
A. T. Hammond and B. S. Glick (2000)
Mol. Biol. Cell 11, 3013-3030
   Abstract »    Full Text »
ch-TOGp Is Required for Microtubule Aster Formation in a Mammalian Mitotic Extract.
M. A. Dionne, A. Sanchez, and D. A. Compton (2000)
J. Biol. Chem. 275, 12346-12352
   Abstract »    Full Text »    PDF »
Cell Cycle-regulated Proteolysis of Mitotic Target Proteins.
H. Bastians, L. M. Topper, G. L. Gorbsky, and J. V. Ruderman (1999)
Mol. Biol. Cell 10, 3927-3941
   Abstract »    Full Text »
The Kinesin-related Protein, HSET, Opposes the Activity of Eg5 and Cross-links Microtubules in the Mammalian Mitotic Spindle.
V. Mountain, C. Simerly, L. Howard, A. Ando, G. Schatten, and D. A. Compton (1999)
J. Cell Biol. 147, 351-366
   Abstract »    Full Text »    PDF »
Biparental Inheritance of gamma -Tubulin during Human Fertilization: Molecular Reconstitution of Functional Zygotic Centrosomes in Inseminated Human Oocytes and in Cell-free Extracts Nucleated by Human Sperm.
C. Simerly, S. S. Zoran, C. Payne, T. Dominko, P. Sutovsky, C. S. Navara, J. L. Salisbury, and G. Schatten (1999)
Mol. Biol. Cell 10, 2955-2969
   Abstract »    Full Text »
Centrosome Abnormalities in Pancreatic Ductal Carcinoma.
N. Sato, K. Mizumoto, M. Nakamura, K. Nakamura, M. Kusumoto, H. Niiyama, T. Ogawa, and M. Tanaka (1999)
Clin. Cancer Res. 5, 963-970
   Abstract »    Full Text »    PDF »
Dynein is required for spindle assembly in cytoplasmic extracts of Spisula solidissima oocytes.
R. Palazzo, E. Vaisberg, D. Weiss, S. Kuznetsov, and W Steffen (1999)
J. Cell Sci. 112, 1291-1302
   Abstract »    PDF »
An Ordered Inheritance Strategy for the Golgi Apparatus: Visualization of Mitotic Disassembly Reveals a Role for the Mitotic Spindle.
D. T. Shima, N. Cabrera-Poch, R. Pepperkok, and G. Warren (1998)
J. Cell Biol. 141, 955-966
   Abstract »    Full Text »    PDF »
Endomitosis of Human Megakaryocytes Are Due to Abortive Mitosis.
N. Vitrat, K. Cohen-Solal, C. Pique, J. P. LeCouedic, F. Norol, A. K. Larsen, A. Katz, W. Vainchenker, and N. Debili (1998)
Blood 91, 3711-3723
   Abstract »    Full Text »    PDF »
Spc98p Directs the Yeast gamma -Tubulin Complex into the Nucleus and Is Subject to Cell Cycle-dependent Phosphorylation on the Nuclear Side of the Spindle Pole Body.
G. Pereira, M. Knop, and E. Schiebel (1998)
Mol. Biol. Cell 9, 775-793
   Abstract »    Full Text »
Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes.
T. Gaglio, M. A. Dionne, and D. A. Compton (1997)
J. Cell Biol. 138, 1055-1066
   Abstract »    Full Text »    PDF »
Centrosome-microtubule nucleation.
G Pereira and E Schiebel (1997)
J. Cell Sci. 110, 295-300
   Abstract »    PDF »
Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein.
H Liao, G Li, and T. Yen (1994)
Science 265, 394-398
   Abstract »    PDF »
Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.
R. Golsteyn, S. Schultz, J Bartek, A Ziemiecki, T Ried, and E. Nigg (1994)
J. Cell Sci. 107, 1509-1517
   Abstract »    PDF »
A chromosome breakage assay to monitor mitotic forces in budding yeast.
J. Brock and K Bloom (1994)
J. Cell Sci. 107, 891-902
   Abstract »    PDF »
Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles.
R Errabolu, M. Sanders, and J. Salisbury (1994)
J. Cell Sci. 107, 9-16
   Abstract »    PDF »
Kinesin-like molecules involved in spindle formation.
V. Rodionov, V. Gelfand, and G. Borisy (1993)
J. Cell Sci. 106, 1179-1188
   Abstract »    PDF »
Microtubule organization during the cell cycle of the primitive eukaryote dinoflagellate Crypthecodinium cohnii.
E Perret, J Davoust, M Albert, L Besseau, and M. Soyer-Gobillard (1993)
J. Cell Sci. 104, 639-651
   Abstract »    PDF »
Microinjection of a monoclonal antibody against SPN antigen, now identified by peptide sequences as the NuMA protein, induces micronuclei in PtK2 cells.
M Kallajoki, J Harborth, K Weber, and M Osborn (1993)
J. Cell Sci. 104, 139-150
   Abstract »    PDF »
Disorganization of the Golgi complex and the cytoplasmic microtubule system in CHO cells exposed to okadaic acid.
J. Thyberg and S. Moskalewski (1992)
J. Cell Sci. 103, 1167-1175
   Abstract »    PDF »
Multiple Kinesin-related Proteins in Yeast Mitosis.
D.M. Roof, P.B. Meluh, and M.D. Rose (1991)
Cold Spring Harb Symp Quant Biol 56, 693-703
   Abstract »    PDF »
G1 events and regulation of cell proliferation.
A. Pardee (1989)
Science 246, 603-608
   Abstract »    PDF »
Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein.
G. J. Mack and D. A. Compton (2001)
PNAS 98, 14434-14439
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)