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Science 29 September 1989:
Vol. 245. no. 4925, pp. 1511 - 1513
DOI: 10.1126/science.2781295
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Articles

Science, Vol 245, Issue 4925, 1511-1513
Copyright © 1989 by American Association for the Advancement of Science

articles

Factors that predict individual vulnerability to amphetamine self-administration

PV Piazza, JM Deminiere, M Le Moal, and H Simon

INSERM U.259, Universite de Bordeaux II, France.

Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.


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