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Science 29 September 1989:
Vol. 245. no. 4925, pp. 1502 - 1505
DOI: 10.1126/science.2781292
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Articles

Science, Vol 245, Issue 4925, 1502-1505
Copyright © 1989 by American Association for the Advancement of Science

articles

Effects of glucocorticoids and norepinephrine on the excitability in the hippocampus

M Joels and ER de Kloet

Division of Molecular Neurobiology, University of Utrecht, The Netherlands.

The CA1 pyramidal neurons in the hippocampus contain a high density of adrenal corticosteroid receptors. By intracellular recording, CA1 neurons in slices from adrenalectomized rats have been found to display a markedly reduced afterhyperpolarization (that is, the hyperpolarizing phase after a brief depolarizing current pulse) when compared with their sham controls. No differences were found for other tested membrane properties. Brief exposure of hippocampal slices from adrenalectomized rats to glucocorticoid agonists, 30 to 90 minutes before recording, greatly enhanced the afterhyperpolarization. In addition, glucocorticoids attenuated the norepinephrine-induced blockade of action potential accommodation in CA1 neurons. The findings indicate that glucocorticoids can reduce transmitter-evoked excitability in the hippocampus, presumably via a receptor-mediated genomic action.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)