Science 22 September 1989: Vol. 245. no. 4924, pp. 1389 - 1392 DOI: 10.1126/science.2551039

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GABAA Receptor {alpha}5 Subunits Contribute to GABAA,slow Synaptic Inhibition in Mouse Hippocampus.

E. D. Zarnowska, R. Keist, U. Rudolph, and R. A. Pearce (2009)
J Neurophysiol 101, 1179-1191
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Tonic GABAergic Inhibition of Sympathetic Preganglionic Neurons: A Novel Substrate for Sympathetic Control.

L. Wang, E. Spary, J. Deuchars, and S. A. Deuchars (2008)
J. Neurosci. 28, 12445-12452
 |  Abstract »  |  Full Text »  |  PDF »

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection.

J. A. Lieberman, F. P. Bymaster, H. Y. Meltzer, A. Y. Deutch, G. E. Duncan, C. E. Marx, J. R. Aprille, D. S. Dwyer, X.-M. Li, S. P. Mahadik, et al. (2008)
Pharmacol. Rev. 60, 358-403
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Surface Expression of GABAA Receptors Is Transcriptionally Controlled by the Interplay of cAMP-response Element-binding Protein and Its Binding Partner Inducible cAMP Early Repressor.

Y. Hu, I. V. Lund, M. C. Gravielle, D. H. Farb, A. R. Brooks-Kayal, and S. J. Russek (2008)
J. Biol. Chem. 283, 9328-9340
 |  Abstract »  |  Full Text »  |  PDF »

Reticular nucleus-specific changes in {alpha}3 subunit protein at GABA synapses in genetically epilepsy-prone rats.

X.-B. Liu, J. Coble, G. van Luijtelaar, and E. G. Jones (2007)
PNAS 104, 12512-12517
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Differential contribution of GABAA receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.

R. L. Fradley, M. R. Guscott, S. Bull, D. J. Hallett, S. C. Goodacre, K. A. Wafford, E. M. Garrett, R. J. Newman, G. F. O'Meara, P. J. Whiting, et al. (2007)
J Psychopharmacol 21, 384-391
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In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells.

I. Marchionni, A. Omrani, and E. Cherubini (2007)
J. Physiol. 581, 515-528
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Ambient GABA Promotes Cortical Entry of Tangentially Migrating Cells Derived from the Medial Ganglionic Eminence.

V. C. Cuzon, P. W. Yeh, Q. Cheng, and H. H. Yeh (2006)
Cereb Cortex 16, 1377-1388
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Distinct Functional Characteristics of the Lateral/Basolateral Amygdala GABAergic System in C57BL/6J and DBA/2J Mice.

D. W. DuBois, A. Perlegas, D. W. Floyd, J. L. Weiner, and B. A. McCool (2006)
J. Pharmacol. Exp. Ther. 318, 629-640
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Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor {beta}1 subunit.

M. M. Huntsman and J. R. Huguenard (2006)
J. Physiol. 572, 459-475
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a Significant Role of {alpha}3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines.

R. Dias, W. F. A. Sheppard, R. L. Fradley, E. M. Garrett, J. L. Stanley, S. J. Tye, S. Goodacre, R. J. Lincoln, S. M. Cook, R. Conley, et al. (2005)
J. Neurosci. 25, 10682-10688
 |  Abstract »  |  Full Text »  |  PDF »

Cortical {gamma}-Aminobutyric Acid Type A-Benzodiazepine Receptors in Recovery From Alcohol Dependence: Relationship to Features of Alcohol Dependence and Cigarette Smoking.

J. K. Staley, C. Gottschalk, I. L. Petrakis, R. Gueorguieva, S. O'Malley, R. Baldwin, P. Jatlow, N. P. L. G. Verhoeff, E. Perry, D. Weinzimmer, et al. (2005)
Arch Gen Psychiatry 62, 877-888
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Contribution of GABAA Receptor Subtypes to the Anxiolytic-Like, Motor, and Discriminative Stimulus Effects of Benzodiazepines: Studies with the Functionally Selective Ligand SL651498 [6-Fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one].

S. C. Licata, D. M. Platt, J. M. Cook, P. V. V. S. Sarma, G. Griebel, and J. K. Rowlett (2005)
J. Pharmacol. Exp. Ther. 313, 1118-1125
 |  Abstract »  |  Full Text »  |  PDF »

Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator.

A. Lippa, P. Czobor, J. Stark, B. Beer, E. Kostakis, M. Gravielle, S. Bandyopadhyay, S. J. Russek, T. T. Gibbs, D. H. Farb, et al. (2005)
PNAS 102, 7380-7385
 |  Abstract »  |  Full Text »  |  PDF »

Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.

J. K. Rowlett, D. M. Platt, S. Lelas, J. R. Atack, and G. R. Dawson (2005)
PNAS 102, 915-920
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Ethanol Self-Administration by Cynomolgus Macaques Alters the Pharmacology and Expression of GABAA Receptors in Basolateral Amygdala.

D. W. Floyd, D. P. Friedman, J. B. Daunais, P. J. Pierre, K. A. Grant, and B. A. McCool (2004)
J. Pharmacol. Exp. Ther. 311, 1071-1079
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Pharmacological Characterization of Indiplon, a Novel Pyrazolopyrimidine Sedative-Hypnotic.

A. C. Foster, M. A. Pelleymounter, M. J. Cullen, D. Lewis, M. Joppa, T. K. Chen, H. P. Bozigian, R. S. Gross, and K. R. Gogas (2004)
J. Pharmacol. Exp. Ther. 311, 547-559
 |  Abstract »  |  Full Text »  |  PDF »

Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses.

F.-C. Hsu, G.-J. Zhang, Y. S. H. Raol, R. J. Valentino, D. A. Coulter, and A. R. Brooks-Kayal (2003)
PNAS 100, 12213-12218
 |  Abstract »  |  Full Text »  |  PDF »

GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation.

D D Wang, D D Krueger, and A Bordey (2003)
J. Physiol. 550, 785-800
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GABAA Receptor beta 3 Subunit Deletion Decreases alpha 2/3 Subunits and IPSC Duration.

E. Ramadan, Z. Fu, G. Losi, G. E. Homanics, J. H. Neale, and S. Vicini (2003)
J Neurophysiol 89, 128-134
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Prolongation of Hippocampal Miniature Inhibitory Postsynaptic Currents in Mice Lacking the GABAA Receptor alpha 1 Subunit.

P. A. Goldstein, F. P. Elsen, S.-W. Ying, C. Ferguson, G. E. Homanics, and N. L. Harrison (2002)
J Neurophysiol 88, 3208-3217
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Molecular and Pharmacological Characterization of GABAA Receptor alpha 1 Subunit Knockout Mice.

J. E. Kralic, E. R. Korpi, T. K. O'Buckley, G. E. Homanics, and A. L. Morrow (2002)
J. Pharmacol. Exp. Ther. 302, 1037-1045
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Kinetic and Pharmacological Properties of GABAA Receptors in Single Thalamic Neurons and GABAA Subunit Expression.

S. H. Browne, J. Kang, G. Akk, L. W. Chiang, H. Schulman, J. R. Huguenard, and D. A. Prince (2001)
J Neurophysiol 86, 2312-2322
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GABAA Receptor {alpha}1 Subunit Deletion Prevents Developmental Changes of Inhibitory Synaptic Currents in Cerebellar Neurons.

S. Vicini, C. Ferguson, K. Prybylowski, J. Kralic, A. L. Morrow, and G. E. Homanics (2001)
J. Neurosci. 21, 3009-3016
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GABAA Receptors Containing {alpha}5 Subunits in the CA1 and CA3 Hippocampal Fields Regulate Ethanol-Motivated Behaviors: An Extended Ethanol Reward Circuitry.

H. L. June, S. C. Harvey, K. L. Foster, P. F. McKay, R. Cummings, M. Garcia, D. Mason, C. Grey, S. McCane, L. S. Williams, et al. (2001)
J. Neurosci. 21, 2166-2177
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Neurobiological Mechanisms of the Onset of Puberty in Primates.

E. Terasawa and D. L. Fernandez (2001)
Endocr. Rev. 22, 111-151
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Effects of Chronic Ethanol Treatment on gamma -Aminobutyric AcidA and Glycine Receptors in Mouse Glycinergic Spinal Neurons.

B. van Zundert, F. A. Albarran, and L. G. Aguayo (2000)
J. Pharmacol. Exp. Ther. 295, 423-429
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Target-specific expression of pre- and postsynaptic mechanisms.

K. Toth and C. J McBain (2000)
J. Physiol. 525, 41-51
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Synaptic Control of Motoneuronal Excitability.

J. C. Rekling, G. D. Funk, D. A. Bayliss, X.-W. Dong, and J. L. Feldman (2000)
Physiol Rev 80, 767-852
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Regionally Selective Blockade of GABAergic Inhibition by Zinc in the Thalamocortical System: Functional Significance.

J. W. Gibbs III, Y.-F. Zhang, M. D. Shumate, and D. A. Coulter (2000)
J Neurophysiol 83, 1510-1521
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Subunit Composition and Pharmacological Characterization of {gamma}-Aminobutyric Acid Type A Receptors in Frog Pituitary Melanotrophs.

E. Louiset, R. McKernan, W. Sieghart, and H. Vaudry (2000)
Endocrinology 141, 1083-1092
 |  Abstract »  |  Full Text »  |  PDF »

Zinc Inhibition of gamma -Aminobutyric AcidA Receptor Function Is Decreased in the Cerebral Cortex during Pilocarpine-Induced Status Epilepticus.

P. K. Banerjee, R. W. Olsen, and O. C. Snead III (1999)
J. Pharmacol. Exp. Ther. 291, 361-366
 |  Abstract »  |  Full Text »

Human Neuronal gamma -Aminobutyric AcidA Receptors: Coordinated Subunit mRNA Expression and Functional Correlates in Individual Dentate Granule Cells.

A. R. Brooks-Kayal, M. D. Shumate, H. Jin, D. D. Lin, T. Y. Rikhter, K. L. Holloway, and D. A. Coulter (1999)
J. Neurosci. 19, 8312-8318
 |  Abstract »  |  Full Text »  |  PDF »

Mutagenesis of the Rat alpha 1 Subunit of the gamma -Aminobutyric AcidA Receptor Reveals the Importance of Residue 101 in Determining the Allosteric Effects of Benzodiazepine Site Ligands.

S. M. J. Dunn, M. Davies, A. L. Muntoni, and J. J. Lambert (1999)
Mol. Pharmacol. 56, 768-774
 |  Abstract »  |  Full Text »

Native gamma -Aminobutyric Acid Type A Receptors from Rat Hippocampus, Containing Both alpha 1 and alpha 5 Subunits, Exhibit a Single Benzodiazepine Binding Site with alpha 5 Pharmacological Properties.

F. Araujo, D. Ruano, and J. Vitorica (1999)
J. Pharmacol. Exp. Ther. 290, 989-997
 |  Abstract »  |  Full Text »

GABAA Receptors Expressed in Undifferentiated Human Teratocarcinoma NT2 Cells Differ from Those Expressed by Differentiated NT2-N Cells.

T. R. Neelands, J. Zhang, and R. L. Macdonald (1999)
J. Neurosci. 19, 7057-7065
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Differential Expression of alpha 1, alpha 2, alpha 3, and alpha 5 GABAA Receptor Subunits in Seizure-Prone and Seizure-Resistant Rat Models of Temporal Lobe Epilepsy.

M. O. Poulter, L. A. Brown, S. Tynan, G. Willick, R. William, and D. C. McIntyre (1999)
J. Neurosci. 19, 4654-4661
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In situ hybridization histochemistry as a method to assess GABAAreceptor subunit mRNA expression following chronic alprazolam administration.

J. M. Fahey, G. A. Pritchard, J. M. Grassi, J. S. Pratt, R. I. Shader, and D. J. Greenblatt (1999)
J Psychopharmacol 13, 211-218
 |  Abstract »  |  PDF »

Zinc and Flunitrazepam Modulation of GABA-Mediated Currents in Rat Suprachiasmatic Neurons.

G. J. Strecker, W. K. Park, and F. E. Dudek (1999)
J Neurophysiol 81, 184-191
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Altered ratios of alternatively spliced long and short gamma 2 subunit mRNAs of the gamma -amino butyrate type A receptor in prefrontal cortex of schizophrenics.

M. M. Huntsman, B.-V. Tran, S. G. Potkin, W. E. Bunney Jr., and E. G. Jones (1998)
PNAS 95, 15066-15071
 |  Abstract »  |  Full Text »  |  PDF »

Decreased Benzodiazepine Binding with Little Effect on gamma -Aminobutyric Acid Binding in Rat Brain After Treatment with Antisense Oligodeoxynucleotide to the gamma -Aminobutyric AcidA Receptor Gamma-2 Subunit.

T.-J. Zhao, M. Li, T. H. Chiu, and H. C. Rosenberg (1998)
J. Pharmacol. Exp. Ther. 287, 752-759
 |  Abstract »  |  Full Text »

Rat and Human Hippocampal alpha 5 Subunit-Containing gamma -Aminobutyric AcidA Receptors Have alpha 5beta 3gamma 2 Pharmacological Characteristics.

C. Sur, K. Quirk, D. Dewar, J. Atack, and R. McKernan (1998)
Mol. Pharmacol. 54, 928-933
 |  Abstract »  |  Full Text »

Zinc and Zolpidem Modulate mIPSCs in Rat Neocortical Pyramidal Neurons.

T. Defazio and J. J. Hablitz (1998)
J Neurophysiol 80, 1670-1677
 |  Abstract »  |  Full Text »  |  PDF »

Segregation of Different GABAA Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells.

Z. Nusser, W. Sieghart, and P. Somogyi (1998)
J. Neurosci. 18, 1693-1703
 |  Abstract »  |  Full Text »  |  PDF »

Differences in Agonist/Antagonist Binding Affinity and Receptor Transduction Using Recombinant Human gamma -Aminobutyric Acid Type A Receptors.

B. Ebert, S. A. Thompson, K. Saounatsou, R. McKernan, P. Krogsgaard-Larsen, and K. A. Wafford (1997)
Mol. Pharmacol. 52, 1150-1156
 |  Abstract »  |  Full Text »

Key Amino Acids in the gamma  Subunit of the gamma -Aminobutyric AcidA Receptor that Determine Ligand Binding and Modulation at the Benzodiazepine Site.

P. B. Wingrove, S. A. Thompson, K. A. Wafford, and P. J. Whiting (1997)
Mol. Pharmacol. 52, 874-881
 |  Abstract »  |  Full Text »

Interactions of the Neurosteroid Dehydroepiandrosterone Sulfate with the GABAA Receptor Complex Reveals that it May Act via the Picrotoxin Site.

A. Sousa and M. K. Ticku (1997)
J. Pharmacol. Exp. Ther. 282, 827-833
 |  Abstract »  |  Full Text »

Waglerin-1 Modulates gamma -Aminobutyric Acid Activated Current of Murine Hypothalamic Neurons.

J.-H. Ye and J. J. McArdle (1997)
J. Pharmacol. Exp. Ther. 282, 74-80
 |  Abstract »  |  Full Text »

Coexistence of Two beta  Subunit Isoforms in the Same gamma -Aminobutyric Acid Type A Receptor.

M. Li and A. L. De Blas (1997)
J. Biol. Chem. 272, 16564-16569
 |  Abstract »  |  Full Text »  |  PDF »

Flunitrazepam Has an Inverse Agonistic Effect on Recombinant alpha 6beta 2gamma 2-GABAA Receptors via a Flunitrazepam-binding Site.

C. A. E. Hauser, C. H. R. Wetzel, B. Berning, F. M. Gerner, and R. Rupprecht (1997)
J. Biol. Chem. 272, 11723-11727
 |  Abstract »  |  Full Text »  |  PDF »

Two Tyrosine Residues on the alpha  Subunit Are Crucial for Benzodiazepine Binding and Allosteric Modulation of gamma -Aminobutyric AcidA Receptors.

J. Amin, A. Brooks-Kayal, and D. S. Weiss (1997)
Mol. Pharmacol. 51, 833-841
 |  Abstract »  |  Full Text »

GABAA Receptors Mediate Trophic Effects of GABA on Embryonic Brainstem Monoamine Neurons In Vitro.

J. Liu, A. L. Morrow, L. Devaud, D. R. Grayson, and J. M. Lauder (1997)
J. Neurosci. 17, 2420-2428
 |  Abstract »  |  Full Text »  |  PDF »

N-Methyl-D-aspartate Receptors Expressed in a Nonneuronal Cell Line Mediate Subunit-specific Increases in Free Intracellular Calcium.

E. R. Grant, B. J. Bacskai, D. E. Pleasure, D. B. Pritchett, M. J. Gallagher, S. J. Kendrick, L. J. Kricka, and D. R. Lynch (1997)
J. Biol. Chem. 272, 647-656
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and Pharmacological Characterization of Native Cortical gamma -Aminobutyric AcidA Receptors Containing Both alpha 1 and alpha 3 Subunits.

F. Araujo, S. Tan, D. Ruano, H. Schoemaker, J. Benavides, and J. Vitorica (1996)
J. Biol. Chem. 271, 27902-27911
 |  Abstract »  |  Full Text »  |  PDF »

Nucleus-Specific Expression of GABAA Receptor Subunit mRNAs in Monkey Thalamus.

M. M. Huntsman, M. G. Leggio, and E. G. Jones (1996)
J. Neurosci. 16, 3571-3589
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of benzodiazepine (BZ) receptor agonists in two rodent activity tests.

P.J. Bayley, G.D. Bentley, A. Jackson, D. Williamson, and G.R. Dawson (1996)
J Psychopharmacol 10, 206-213
 |  Abstract »  |  PDF »

Endogenous Phosphorylation of Distinct [IMAGE]-Aminobutyric Acid Type A Receptor Polypeptides by Ser/Thr and Tyr Kinase Activities Associated with the Purified Receptor.

M. H. Bureau and J. J. Laschet (1995)
J. Biol. Chem. 270, 26482-26487
 |  Abstract »  |  Full Text »  |  PDF »

Assessment of the interaction between a partial agonist and a full agonist of benzodiazepine receptors, based on psychomotor performance and memory, in healthy volunteers.

A. Patat, M.C. Perault, B. Vandel, Ph. Danjou, S. Brohier, I. Zieleniuk, and P. Rosenzweig (1995)
J Psychopharmacol 9, 91-101
 |  Abstract »  |  PDF »

Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor.

N Burnashev, R Schoepfer, H Monyer, J. Ruppersberg, W Gunther, P. Seeburg, and B Sakmann (1992)
Science 257, 1415-1419
 |  Abstract »  |  PDF »

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes.

H. Monyer, R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N. Burnashev, B. Sakmann, and P. H. Seeburg (1992)
Science 256, 1217-1221
 |  Abstract »  |  PDF »

Levels of GABAa receptor subunit mRNA in rat brain following flurazepam treatment.

M. C. O'Donovan, P. R. Buckland, and P. McGuffin (1992)
J Psychopharmacol 6, 364-369
 |  Abstract »  |  PDF »

Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.

B Sommer, K Keinanen, T. Verdoorn, W Wisden, N Burnashev, A Herb, M Kohler, T Takagi, B Sakmann, and P. Seeburg (1990)
Science 249, 1580-1585
 |  Abstract »  |  PDF »

A family of AMPA-selective glutamate receptors.

K Keinanen, W Wisden, B Sommer, P Werner, A Herb, T. Verdoorn, B Sakmann, and P. Seeburg (1990)
Science 249, 556-560
 |  Abstract »  |  PDF »

The GABAA Receptor Family: Molecular and Functional Diversity.

P.H. Seeburg, W. Wisden, T.A. Verdoorn, D.B. Pritchett, P. Werner, A. Herb, H. Luddens, R. Sprengel, and B. Sakmann (1990)
Cold Spring Harb Symp Quant Biol 55, 29-40
 |  Abstract »  |  PDF »

Ligand Binding and Structural Properties of Segments of GABAA Receptor alpha 1 Subunit Overexpressed in Escherichia coli.

J. Hang, H. Shi, D. Li, Y. Liao, D. Lian, Y. Xiao, and H. Xue (2000)
J. Biol. Chem. 275, 18818-18823
 |  Abstract »  |  Full Text »  |  PDF »

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