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Science 15 September 1989: Vol. 245. no. 4923, pp. 1238 - 1241 DOI: 10.1126/science.2551036
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Articles
Science, Vol 245, Issue 4923, 1238-1241
Copyright © 1989 by American Association for the Advancement of Science
Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors
TK Kishimoto,
MA Jutila,
EL Berg,
and
EC Butcher
Department of Pathology, Stanford University, CA 94305.
The neutrophil Mac-1 and gp100MEL-14 adhesion proteins are involved in neutrophil extravasation during inflammation. Both the expression and activity of Mac-1 are greatly increased after neutrophil activation. In contrast, neutrophils shed gp100MEL-14 from the cell surface within 4 minutes after activation with chemotactic factors or phorbol esters, releasing a 96-kilodalton fragment of the antigen into the supernatant. Immunohistology showed that gp100MEL-14 was downregulated on neutrophils that had extravasated into inflamed tissue. The gp100MEL-14 adhesion protein may participate in the binding of unactivated neutrophils to the endothelium; rapid shedding of gp100MEL-14 may prevent extravasation into and damage of normal tissues by activated neutrophils.
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J. Immunol.
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- Antibody Binding to a Conformation-Dependent Epitope Induces L-Selectin Association with the Detergent-Resistant Cytoskeleton.
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J. Immunol.
166, 4899-4907
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- L-Selectin Shedding Regulates Leukocyte Recruitment.
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- Platelet and Leukocyte Deactivation After Intracoronary Stent Placement in Patients Receiving Combined Antiplatelet Therapy.
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Clinical and Applied Thrombosis/Hemostasis
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- Chemical Glycobiology.
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Science
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- Circulating soluble adhesion molecules in ANCA-associated vasculitis.
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Nephrol. Dial. Transplant.
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- Effects of endotoxin on neutrophil-mediated I/R injury in isolated perfused rat hearts.
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Am J Physiol Heart Circ Physiol
280, H802-H811
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- A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by {beta}1 and {beta}2 integrins.
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Blood
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- Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14.
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Am J Physiol Lung Cell Mol Physiol
280, L58-L68
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- Streptolysin O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral sphingomyelinase.
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- Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-{gamma}.
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Blood
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Arterioscler Thromb Vasc Biol
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- STIMULATION OF NEUTROPHIL INTEGRIN EXPRESSION DURING CORONARY ARTERY BYPASS GRAFTING: COMPARISON OF CRYSTALLOID AND BLOOD CARDIOPLEGIC SOLUTIONS.
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- Introduction: functional polarity of motile neutrophils.
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Blood
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- Shear and Time-Dependent Changes in Mac-1, LFA-1, and ICAM-3 Binding Regulate Neutrophil Homotypic Adhesion.
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- The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells.
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FASEB J
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- Anti-Inflammatory Actions of Lipoxin A4 Stable Analogs Are Demonstrable in Human Whole Blood: Modulation of Leukocyte Adhesion Molecules and Inhibition of Neutrophil-Endothelial Interactions.
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Blood
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