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Science 15 September 1989:
Vol. 245. no. 4923, pp. 1226 - 1227
DOI: 10.1126/science.2781279
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Articles

Science, Vol 245, Issue 4923, 1226-1227
Copyright © 1989 by American Association for the Advancement of Science

articles

Molecular structure of DNA by scanning tunneling microscopy

A Cricenti, S Selci, AC Felici, R Generosi, E Gori, W Djaczenko, and G Chiarotti

Instituto di Struttura della Materia del Consiglio Nazionale delle Ricerche, Frascati, Italy.

Uncoated DNA molecules marked with an activated tris(l-aziridinyl) phosphine oxide (TAPO) solution were deposited on gold substrates and imaged in air with the use of a high-resolution scanning tunneling microscope (STM). Constant-current and gap-modulated STM images show clear evidence of the helicity of the DNA structure: pitch periodicity ranges from 25 to 35 angstroms, whereas the average diameter is 20 angstroms. Molecular structure within a single helix turn was also observed.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)