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Science 8 September 1989:
Vol. 245. no. 4922, pp. 1115 - 1118
DOI: 10.1126/science.2549640
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Articles

Science, Vol 245, Issue 4922, 1115-1118
Copyright © 1989 by American Association for the Advancement of Science

articles

Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle

P Ruth, A Rohrkasten, M Biel, E Bosse, S Regulla, HE Meyer, V Flockerzi, and F Hofmann

Institut fur Physiologische Chemie, Medizinische Fakultat, Homburg/Saar, Federal Republic of Germany.

Complementary DNAs for the beta subunit of the dihydropyridine-sensitive calcium channel of rabbit skeletal muscle were isolated on the basis of peptide sequences derived from the purified protein. The deduced primary structure is without homology to other known protein sequences and is consistent with the beta subunit being a peripheral membrane protein associated with the cytoplasmic aspect of the sarcolemma. The protein contains sites that might be expected to be preferentially phosphorylated by protein kinase C and guanosine 3',5'-monophosphate-dependent protein kinase. A messenger RNA for this protein appears to be expressed in brain.


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J. Biol. Chem. 271, 26465-26468
   Abstract »    Full Text »    PDF »
Transfer of High Sensitivity for Benzothiazepines from L-type to Class A (BI) Calcium Channels.
S. Hering, S. Aczel, M. Grabner, F. Doring, S. Berjukow, J. Mitterdorfer, M. J. Sinnegger, J. Striessnig, V. E. Degtiar, Z. Wang, et al. (1996)
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   Abstract »    Full Text »    PDF »
Transfer of L-type Calcium Channel IVS6 Segment Increases Phenylalkylamine Sensitivity of alpha[IMAGE].
F. Döring, V. E. Degtiar, M. Grabner, Jör. Striessnig, S. Hering, and H. Glossmann (1996)
J. Biol. Chem. 271, 11745-11749
   Abstract »    Full Text »    PDF »
betaSubunit Heterogeneity in N-type Ca[IMAGE] Channels.
V. E. S. Scott, M. De Waard, H. Liu, C. A. Gurnett, D. P. Venzke, V. A. Lennon, and K. P. Campbell (1996)
J. Biol. Chem. 271, 3207-3212
   Abstract »    Full Text »    PDF »
Roles of a Membrane-localized beta Subunit in the Formation and Targeting of Functional L-type Ca[IMAGE] Channels.
A. J. Chien, X. Zhao, R. E. Shirokov, T. S. Puri, C. F. Chang, D. Sun, E. Rios, and M. M. Hosey (1995)
J. Biol. Chem. 270, 30036-30044
   Abstract »    Full Text »    PDF »
Molecular Determinants of Cardiac Ca[IMAGE] Channel Pharmacology.
X. Wei, S. Pan, W. Lang, H. Kim, T. Schneider, E. Perez-Reyes, and L. Birnbaumer (1995)
J. Biol. Chem. 270, 27106-27111
   Abstract »    Full Text »    PDF »
Regulation of Dihydropyridine and Ryanodine Receptor Gene Expression in Skeletal Muscle.
A. Ray, J. Kyselovic, J. J. Leddy, J. T. Wigle, B. J. Jasmin, and B. S. Tuana (1995)
J. Biol. Chem. 270, 25837-25844
   Abstract »    Full Text »    PDF »
Calcium Binding in the Pore of L-type Calcium Channels Modulates High Affinity Dihydropyridine Binding.
B. Z. Peterson and W. A. Catterall (1995)
J. Biol. Chem. 270, 18201-18204
   Abstract »    Full Text »    PDF »
Association of Native Ca[IMAGE] Channel [IMAGE] Subunits with the [IMAGE][IMAGE] Subunit Interaction Domain.
D. R. Witcher, M. D. Waard, H. Liu, M. Pragnell, and K. P. Campbell (1995)
J. Biol. Chem. 270, 18088-18093
   Abstract »    Full Text »    PDF »
Properties of the [IMAGE][IMAGE]-[IMAGE] Anchoring Site in Voltage-dependent Ca[IMAGE] Channels.
M. D. Waard, D. R. Witcher, M. Pragnell, H. Liu, and K. P. Campbell (1995)
J. Biol. Chem. 270, 12056-12064
   Abstract »    Full Text »    PDF »
Different Voltage-dependent Inhibition by Dihydropyridines of Human Ca[IMAGE] Channel Splice Variants.
N. M. Soldatov, A. Bouron, and H. Reuter (1995)
J. Biol. Chem. 270, 10540-10543
   Abstract »    Full Text »    PDF »
Stable Expression and Coupling of Cardiac L-Type Ca2+ Channels With ß1-Adrenoceptors.
A. Yatani, M. Wakamori, T. Niidome, S. Yamamoto, I. Tanaka, Y. Mori, K. Katayama, and S. Green (1995)
Circ. Res. 76, 335-342
   Abstract »    Full Text »
Co-localization of 1,4-dihydropyridine receptor alpha 2/delta subunit and N-CAM during early myogenesis in vitro.
S. Vandaele and F Rieger (1994)
J. Cell Sci. 107, 1217-1227
   Abstract »    PDF »
Cardiac Ion Channels.
A. M. Katz (1993)
N. Engl. J. Med. 328, 1244-1251
   Full Text »
Functional subunit structure of voltage-gated calcium channels.
W. Catterall (1991)
Science 253, 1499-1500
   PDF »
The roles of the subunits in the function of the calcium channel.
D Singer, M Biel, I Lotan, V Flockerzi, F Hofmann, and N Dascal (1991)
Science 253, 1553-1557
   Abstract »    PDF »
Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle.
S. Jay, S. Ellis, A. McCue, M. Williams, T. Vedvick, M. Harpold, and K. Campbell (1990)
Science 248, 490-492
   Abstract »    PDF »
Ca2+-sensitive Inactivation and Facilitation of L-type Ca2+ Channels Both Depend on Specific Amino Acid Residues in a Consensus Calmodulin-binding Motif in thealpha 1C subunit.
R. D. Zuhlke, G. S. Pitt, R. W. Tsien, and H. Reuter (2000)
J. Biol. Chem. 275, 21121-21129
   Abstract »    Full Text »    PDF »
Mechanism of Dihydropyridine Interaction with Critical Binding Residues of L-type Ca2+ Channel alpha 1 Subunits.
E. Wappl, J. Mitterdorfer, H. Glossmann, and J. Striessnig (2001)
J. Biol. Chem. 276, 12730-12735
   Abstract »    Full Text »    PDF »
Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels.
G. S. Pitt, R. D. Zuhlke, A. Hudmon, H. Schulman, H. Reuter, and R. W. Tsien (2001)
J. Biol. Chem. 276, 30794-30802
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)