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Science 8 September 1989:
Vol. 245. no. 4922, pp. 1107 - 1110
DOI: 10.1126/science.2672339
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Articles

Science, Vol 245, Issue 4922, 1107-1110
Copyright © 1989 by American Association for the Advancement of Science

articles

Lineage-specific requirement of c-abl function in normal hematopoiesis

D Caracciolo, M Valtieri, D Venturelli, C Peschle, AM Gewirtz, and B Calabretta

Istituto di Medicina ed Oncologia Sperimentale, Sezione di Ematologia, Torino, Italy.

Structural abnormalities of the c-abl proto-oncogene are found in hematopoietic cells of more than 90 percent of individuals with chronic myelogenous leukemia. Therefore c-abl may be important in normal as well as malignant hematopoiesis. Normal human hematopoietic progenitor cells were exposed to three different c-abl sense or antisense oligodeoxynucleotides, and the effects on myeloid and erythroid colony formation were examined. The c-abl antisense oligodeoxynucleotides inhibited myeloid, but not erythroid, colony formation. The c-abl sense oligodeoxynucleotides and bcr sense and antisense oligodeoxynucleotides were not inhibitory in this assay. These data show that c-abl is critical in normal myelopoiesis and may explain the relatively selective expansion of leukocytes in patients with chronic myelogenous leukemia.


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Antileukemia effect of c-myc N3'right-arrowP5' phosphoramidate antisense oligonucleotides in vivo.
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Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity..
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Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides.
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