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Science 8 September 1989:
Vol. 245. no. 4922, pp. 1054 - 1058
DOI: 10.1126/science.2672337
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Articles

Science, Vol 245, Issue 4922, 1054-1058
Copyright © 1989 by American Association for the Advancement of Science

articles

Dictyostelium discoideum: a model system for cell-cell interactions in development

P Devreotes

Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

The cellular slime mold Dictyostelium discoideum undergoes a transition from single-celled amoebae to a multicellular organism as a natural part of its life cycle. A method of cell-cell signaling that controls chemotaxis, morphogenesis, and gene expression has developed in this organism, and a detailed understanding of this signaling system provides clues to mechanisms of intercellular communication in the development of metazoans.


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PldB, a Putative Phospholipase D Homologue in Dictyostelium discoideum Mediates Quorum Sensing during Development.
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Disruption of Aldehyde Reductase Increases Group Size in Dictyostelium.
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CF45-1, a Secreted Protein Which Participates in Dictyostelium Group Size Regulation.
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A Second UDP-glucose Pyrophosphorylase Is Required for Differentiation and Development in Dictyostelium discoideum.
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Cells Respond to and Bind Countin, a Component of a Multisubunit Cell Number Counting Factor.
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J. Biol. Chem. 277, 32596-32605
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How well can an amoeba climb?.
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PNAS 97, 10020-10025
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A cell-counting factor regulating structure size in Dictyostelium.
D. A. Brock and R. H. Gomer (1999)
Genes & Dev. 13, 1960-1969
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ABC transporter-facilitated ATP conductive transport.
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Am J Physiol Cell Physiol 276, C1-C8
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EDF-1, a Novel Gene Product Down-regulated in Human Endothelial Cell Differentiation.
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A Deubiquitinating Enzyme That Disassembles Free Polyubiquitin Chains Is Required for Development but Not Growth in Dictyostelium.
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Cell Density Sensing Mediated by a G Protein-coupled Receptor Activating Phospholipase C.
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Cell-type-specific rescue of myosin function during Dictyostelium development defines two distinct cell movements required for culmination.
T. Chen, W. Wolf, and R. Chisholm (1998)
Development 125, 3895-3903
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Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion.
K. Francis and B. O. Palsson (1997)
PNAS 94, 12258-12262
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Desynchronization of cells on the developmental path triggers the formation of spiral waves of cAMP during Dictyostelium aggregation.
J. Lauzeral, J. Halloy, and A. Goldbeter (1997)
PNAS 94, 9153-9158
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Twisted scroll waves organize Dictyostelium mucoroides slugs.
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Constitutively Active Adenylyl Cyclase Mutant Requires Neither G Proteins nor Cytosolic Regulators.
C. A. Parent and P. N. Devreotes (1996)
J. Biol. Chem. 271, 18333-18336
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A Dictystelium mutant with defective aggregate size determination.
D. Brock, G Buczynski, T. Spann, S. Wood, J Cardelli, and R. Gomer (1996)
Development 122, 2569-2578
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Isolation of Inactive and G Protein-resistant Adenylyl Cyclase Mutants Using Random Mutagenesis.
C. A. Parent and P. N. Devreotes (1995)
J. Biol. Chem. 270, 22693-22696
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Seven Helix cAMP Receptors Stimulate Ca[IMAGE] Entry in the Absence of Functional G Proteins in Dictyostelium.
J. L. S. Milne, L. Wu, M. J. Caterina, and P. N. Devreotes (1995)
J. Biol. Chem. 270, 5926-5931
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Dishevelled is a component of the frizzled signaling pathway in Drosophila.
R. Krasnow, L. Wong, and P. Adler (1995)
Development 121, 4095-4102
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Mutants lacking myosin II cannot resist forces generated during multicellular morphogenesis.
E Shelden and D. Knecht (1995)
J. Cell Sci. 108, 1105-1115
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LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium..
J L Dynes, A M Clark, G Shaulsky, A Kuspa, W F Loomis, and R A Firtel (1994)
Genes & Dev. 8, 948-958
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Regulatory role of the G alpha 1 subunit in controlling cellular morphogenesis in Dictyostelium.
S Dharmawardhane, A. Cubitt, A. Clark, and R. Firtel (1994)
Development 120, 3549-3561
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cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.
S. Mann and R. Firtel (1993)
Development 119, 135-146
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Cyclic AMP- and Ins(1,4,5)P3-induced Ca2+ fluxes in permeabilised cells of Dictyostelium discoideum: cGMP regulates Ca2+ entry across the plasma membrane.
H Flaadt, E Jaworski, C Schlatterer, and D Malchow (1993)
J. Cell Sci. 105, 255-261
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A density-sensing factor controls development in Dictyostelium..
R Jain, I S Yuen, C R Taphouse, and R H Gomer (1992)
Genes & Dev. 6, 390-400
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Molecular Genetic Analysis of Signal Transduction Pathways Controlling Multicellular Development in Dictyostelium.
A.B. Cubitt, F. Carrel, S. Dharmawardhane, C. Gaskins, J. Hadwiger, P. Howard, S.K.O. Mann, K. Okaichi, K. Zhou, and R.A. Firtel (1992)
Cold Spring Harb Symp Quant Biol 57, 177-192
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Analysis of G alpha 4, a G-protein subunit required for multicellular development in Dictyostelium..
J A Hadwiger and R A Firtel (1992)
Genes & Dev. 6, 38-49
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Diversity of G proteins in signal transduction.
M. Simon, M. Strathmann, and N Gautam (1991)
Science 252, 802-808
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Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium..
T J Sun and P N Devreotes (1991)
Genes & Dev. 5, 572-582
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Expression of a cAMP receptor gene of Dictyostelium and evidence for a multigene family..
C L Saxe, R L Johnson, P N Devreotes, and A R Kimmel (1991)
Genes & Dev. 5, 1-8
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cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium..
R K Esch and R A Firtel (1991)
Genes & Dev. 5, 9-21
   Abstract »    PDF »
A cell number-counting factor regulates the cytoskeleton and cell motility in Dictyostelium.
L. Tang, T. Gao, C. McCollum, W. Jang, M. G. Vicker, R. R. Ammann, and R. H. Gomer (2002)
PNAS 99, 1371-1376
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Light affects cAMP signaling and cell movement activity in Dictyostelium discoideum.
K. Miura and F. Siegert (2000)
PNAS 97, 2111-2116
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