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Science 25 August 1989:
Vol. 245. no. 4920, pp. 859 - 862
DOI: 10.1126/science.2772637
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Articles

Science, Vol 245, Issue 4920, 859-862
Copyright © 1989 by American Association for the Advancement of Science

articles

Buprenorphine suppresses cocaine self-administration by rhesus monkeys

NK Mello, JH Mendelson, MP Bree, and SE Lukas

Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02178.

Cocaine abuse has reached epidemic proportions in the United States, and the search for an effective pharmacotherapy continues. Because primates self-administer most of the drugs abused by humans, they can be used to predict the abuse liability of new drugs and for preclinical evaluation of new pharmacotherapies for drug abuse treatment. Daily administration of buprenorphine (an opioid mixed agonist-antagonist) significantly suppressed cocaine self-administration by rhesus monkeys for 30 consecutive days. The effects of buprenorphine were dose-dependent. The suppression of cocaine self-administration by buprenorphine did not reflect a generalized suppression of behavior. These data suggest that buprenorphine would be a useful pharmacotherapy for treatment of cocaine abuse. Because buprenorphine is a safe and effective pharmacotherapy for heroin dependence, buprenorphine treatment may also attenuate dual abuse of cocaine and heroin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Methadone Versus Buprenorphine With Contingency Management or Performance Feedback for Cocaine and Opioid Dependence.
R. S. Schottenfeld, M. C. Chawarski, J. R. Pakes, M. V. Pantalon, K. M. Carroll, and T. R. Kosten (2005)
Am J Psychiatry 162, 340-349
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Effects of {micro}-Opioid Agonists on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rhesus Monkeys: Role of {micro}-Agonist Efficacy.
S. S. Negus and N. K. Mello (2002)
J. Pharmacol. Exp. Ther. 300, 1111-1121
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Desipramine in Opioid-Dependent Cocaine Abusers Maintained on Buprenorphine vs Methadone.
A. H. Oliveto, A. Feingold, R. Schottenfeld, P. Jatlow, and T. R. Kosten (1999)
Arch Gen Psychiatry 56, 812-820
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Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine.
J. M. van Ree, M. A. F. M. Gerrits, and L. J. M. J. Vanderschuren (1999)
Pharmacol. Rev. 51, 341-396
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Effects of Phentermine on Responding Maintained under Multiple Fixed-Ratio Schedules of Food and Cocaine Presentation in the Rhesus Monkey.
F. H. E. Wojnicki, R. B. Rothman, K. C. Rice, and J. R. Glowa (1999)
J. Pharmacol. Exp. Ther. 288, 550-560
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The Effects of Buprenorphine on Self-administration of Cocaine and Heroin "Speedball" Combinations and Heroin Alone by Rhesus Monkeys.
N. K. Mello and S. S. Negus (1998)
J. Pharmacol. Exp. Ther. 285, 444-456
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Effects of Proposed Treatments for Cocaine Addiction on Hemodynamic Responsiveness to Cocaine in Conscious Rats.
M. M. Knuepfer and Q. Gan (1997)
J. Pharmacol. Exp. Ther. 283, 592-603
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Buprenorphine vs Methadone Maintenance Treatment for Concurrent Opioid Dependence and Cocaine Abuse.
R. S. Schottenfeld, J. R. Pakes, A. Oliveto, D. Ziedonis, and T. R. Kosten (1997)
Arch Gen Psychiatry 54, 713-720
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Effects of Kappa Opioids on Cocaine Self-Administration by Rhesus Monkeys.
S. S. Negus, N. K. Mello, P. S. Portoghese, and C.-E. Lin (1997)
J. Pharmacol. Exp. Ther. 282, 44-55
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The Effects of Chronic Cocaine Self-Administration on the Menstrual Cycle in Rhesus Monkeys.
N. K. Mello, J. H. Mendelson, M. Kelly, N. Diaz-Migoyo, and J. W. Sholar (1997)
J. Pharmacol. Exp. Ther. 281, 70-83
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Management of Cocaine Abuse and Dependence.
J. H. Mendelson and N. K. Mello (1996)
N. Engl. J. Med. 334, 965-972
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A Controlled Trial of Buprenorphine Treatment for Opioid Dependence.
R. E. Johnson, J. H. Jaffe, and P. J. Fudala (1992)
JAMA 267, 2750-2755
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Effects of Cocaine on Canines' Coronary Arteries.
J. L. Valentine, W. S. Yamanashi, D. Leak, S. Saksanen, B. D. Wagner, and S. W. Phillips (1991)
Angiology 42, 568-575
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Substance Abuse.
R. J. Frances (1991)
JAMA 265, 3171-3172
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Cocaine addiction: psychology and neurophysiology.
F. Gawin (1991)
Science 251, 1580-1586
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The drug dilemma: manipulating the demand.
M. Jarvik (1990)
Science 250, 387-392
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Hooked on Hormones-Reply.
K. B. Kashkin and H. D. Kleber (1990)
JAMA 263, 2049
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