Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 August 1989:
Vol. 245. no. 4919, pp. 758 - 761
DOI: 10.1126/science.2549634
Prev | Table of Contents | Next

Articles

Science, Vol 245, Issue 4919, 758-761
Copyright © 1989 by American Association for the Advancement of Science

articles

Limbic seizures increase neuronal production of messenger RNA for nerve growth factor

CM Gall and PJ Isackson

Department of Anatomy and Neurobiology, University of California, Irvine 92717.

Nerve growth factor (NGF) produced by telencephalic neurons provides critical trophic support for cholinergic neurons of the basal forebrain. In situ hybridization and nuclease protection analyses demonstrate that limbic seizures dramatically increase the amount of messenger RNA for NGF in the neurons of the hippocampal dentate gyrus within 1 hour of seizure onset and in broadly distributed neocortical and olfactory forebrain neurons some hours later. The increased messenger RNA species is indistinguishable from messenger RNA for transcript B of the beta subunit of NGF from mouse submandibular gland. Thus, the expression of a known growth factor is affected by unusual physiological activity, suggesting one route through which trophic interactions between neurons in adult brain can be modified.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of Proneurotrophins and Activation of p75NTR-Mediated Apoptosis via Neurotrophin Receptor-Interacting Factor in Hippocampal Neurons after Seizures.
M. Volosin, C. Trotter, A. Cragnolini, R. S. Kenchappa, M. Light, B. L. Hempstead, B. D. Carter, and W. J. Friedman (2008)
J. Neurosci. 28, 9870-9879
   Abstract »    Full Text »    PDF »
Neural Stem/Progenitor Cells Initiate the Formation of Cellular Networks That Provide Neuroprotection by Growth Factor-Modulated Antioxidant Expression.
L. Madhavan, V. Ourednik, and J. Ourednik (2008)
Stem Cells 26, 254-265
   Abstract »    Full Text »    PDF »
Social Stress Enhances Sympathetic Innervation of Primate Lymph Nodes: Mechanisms and Implications for Viral Pathogenesis.
E. K. Sloan, J. P. Capitanio, R. P. Tarara, S. P. Mendoza, W. A. Mason, and S. W. Cole (2007)
J. Neurosci. 27, 8857-8865
   Abstract »    Full Text »    PDF »
Sympathetic Sprouting Near Sensory Neurons After Nerve Injury Occurs Preferentially on Spontaneously Active Cells and Is Reduced by Early Nerve Block.
W. Xie, J. A. Strong, H. Li, and J.-M. Zhang (2007)
J Neurophysiol 97, 492-502
   Abstract »    Full Text »    PDF »
Molecular Signaling Mechanisms Underlying Epileptogenesis.
J. O. McNamara, Y. Z. Huang, and A. S. Leonard (2006)
Sci. STKE 2006, re12
   Abstract »    Full Text »    PDF »
Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins..
M. Volosin, W. Song, R. D. Almeida, D. R. Kaplan, B. L. Hempstead, and W. J. Friedman (2006)
J. Neurosci. 26, 7756-7766
   Abstract »    Full Text »    PDF »
CAAT/Enhancer-binding Protein {delta} and cAMP-response Element-binding Protein Mediate Inducible Expression of the Nerve Growth Factor Gene in the Central Nervous System.
C. S. McCauslin, V. Heath, A. M. Colangelo, R. Malik, S. Lee, A. Mallei, I. Mocchetti, and P. F. Johnson (2006)
J. Biol. Chem. 281, 17681-17688
   Abstract »    Full Text »    PDF »
Adult Neurogenesis: From Precursors to Network and Physiology.
D. N. Abrous, M. Koehl, and M. Le Moal (2005)
Physiol Rev 85, 523-569
   Abstract »    Full Text »    PDF »
Nerve Growth Factor Receptor Signaling Induces Histone Acetyltransferase Domain-dependent Nuclear Translocation of p300/CREB-binding Protein-associated Factor and hGCN5 Acetyltransferases.
K. Wong, J. Zhang, S. Awasthi, A. Sharma, L. Rogers, E. F. Matlock, C. Van Lint, T. Karpova, J. McNally, and R. Harrod (2004)
J. Biol. Chem. 279, 55667-55674
   Abstract »    Full Text »    PDF »
Emerging Complexity of Layer I in Human Cerebral Cortex.
S. Rakic and N. Zecevic (2003)
Cereb Cortex 13, 1072-1083
   Abstract »    Full Text »    PDF »
Increased Expression of Brain-Derived Neurotrophic Factor Induces Formation of Basal Dendrites and Axonal Branching in Dentate Granule Cells in Hippocampal Explant Cultures.
S. C. Danzer, K. R. C. Crooks, D. C. Lo, and J. O. McNamara (2002)
J. Neurosci. 22, 9754-9763
   Abstract »    Full Text »    PDF »
Neurotrophic Factors and Receptors in the Immature and Adult Spinal Cord after Mechanical Injury or Kainic Acid.
J. Widenfalk, K. Lundstromer, M. Jubran, S. Brene, and L. Olson (2001)
J. Neurosci. 21, 3457-3475
   Abstract »    Full Text »    PDF »
Changes in Activating Protein 1 (AP-1) Composition Correspond with the Biphasic Profile of Nerve Growth Factor mRNA Expression in Rat Hippocampus after Hilus Lesion-Induced Seizures.
R. C. Elliott and C. M. Gall (2000)
J. Neurosci. 20, 2142-2149
   Abstract »    Full Text »    PDF »
Positive Modulation of AMPA Receptors Increases Neurotrophin Expression by Hippocampal and Cortical Neurons.
J. C. Lauterborn, G. Lynch, P. Vanderklish, A. Arai, and C. M. Gall (2000)
J. Neurosci. 20, 8-21
   Abstract »    Full Text »    PDF »
Gating of BDNF-Induced Synaptic Potentiation by cAMP.
L. Boulanger and M. Poo (1999)
Science 284, 1982-1984
   Abstract »    Full Text »
Immunohistochemical Evidence of Seizure-Induced Activation of trk Receptors in the Mossy Fiber Pathway of Adult Rat Hippocampus.
D. K. Binder, M. J. Routbort, and J. O. McNamara (1999)
J. Neurosci. 19, 4616-4626
   Abstract »    Full Text »    PDF »
Regulation of Synaptic Function by Neurotrophic Factors in Vertebrates and Invertebrates: Implications for Development and Learning.
S. E. McKay, A. L. Purcell, and T. J. Carew (1999)
Learn. Mem. 6, 193-215
   Abstract »    Full Text »
Synaptic Reliability Correlates with Reduced Susceptibility to Synaptic Potentiation by Brain-Derived Neurotrophic Factor.
B. Berninger, A. F. Schinder, and M.-m. Poo (1999)
Learn. Mem. 6, 232-242
   Abstract »    Full Text »
Long-range signaling within growing neurites mediated by neurotrophin-3.
S. Chang and S. V. Popov (1999)
PNAS 96, 4095-4100
   Abstract »    Full Text »    PDF »
Selective Inhibition of Kindling Development by Intraventricular Administration of TrkB Receptor Body.
D. K. Binder, M. J. Routbort, T. E. Ryan, G. D. Yancopoulos, and J. O. McNamara (1999)
J. Neurosci. 19, 1424-1436
   Abstract »    Full Text »    PDF »
Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Hippocampus: Modulation of Expression by Seizures and Anti-Excitotoxic Action.
L. A. Opanashuk, R. J. Mark, J. Porter, D. Damm, M. P. Mattson, and K. B. Seroogy (1999)
J. Neurosci. 19, 133-146
   Abstract »    Full Text »    PDF »
Nonobligate Role of Early or Sustained Expression of Immediate-Early Gene Proteins c-Fos, c-Jun, and Zif/268 in Hippocampal Mossy Fiber Sprouting.
W. K. Nahm and J. L. Noebels (1998)
J. Neurosci. 18, 9245-9255
   Abstract »    Full Text »    PDF »
Duration of NMDA-Dependent Synaptic Potentiation in Piriform Cortex In Vivo Is Increased After Epileptiform Bursting.
A. Kapur and L. B. Haberly (1998)
J Neurophysiol 80, 1623-1629
   Abstract »    Full Text »    PDF »
TrkB and TrkC Signaling Are Required for Maturation and Synaptogenesis of Hippocampal Connections.
A. Martinez, S. Alcantara, V. Borrell, J. A. Del Rio, J. Blasi, R. Otal, N. Campos, A. Boronat, M. Barbacid, I. Silos-Santiago, et al. (1998)
J. Neurosci. 18, 7336-7350
   Abstract »    Full Text »    PDF »
beta -Adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT/enhancer-binding protein delta.
A. M. Colangelo, P. F. Johnson, and I. Mocchetti (1998)
PNAS 95, 10920-10925
   Abstract »    Full Text »    PDF »
Nerve growth factor rapidly suppresses basal, NMDA-evoked, and AMPA-evoked nitric oxide synthase activity in rat hippocampus in vivo.
H. H. D. Lam, A. Bhardwaj, M. T. O'Connell, D. F. Hanley, R. J. Traystman, and M. V. Sofroniew (1998)
PNAS 95, 10926-10931
   Abstract »    Full Text »    PDF »
Mechanisms Underlying the Enhancement of Excitatory Synaptic Transmission in Basolateral Amygdala Neurons of the Kindling Rat.
Y. Shoji, E. Tanaka, S. Yamamoto, H. Maeda, and H. Higashi (1998)
J Neurophysiol 80, 638-646
   Abstract »    Full Text »    PDF »
Localized Synaptic Actions of Neurotrophin-4.
X.-h. Wang, B. Berninger, and M.-m. Poo (1998)
J. Neurosci. 18, 4985-4992
   Abstract »    Full Text »    PDF »
Upregulation of L-Type Ca2+ Channels in Reactive Astrocytes after Brain Injury, Hypomyelination, and Ischemia.
R. E. Westenbroek, S. B. Bausch, R. C. S. Lin, J. E. Franck, J. L. Noebels, and W. A. Catterall (1998)
J. Neurosci. 18, 2321-2334
   Abstract »    Full Text »    PDF »
Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity.
M. Canossa, O. Griesbeck, B. Berninger, G. Campana, R. Kolbeck, and H. Thoenen (1997)
PNAS 94, 13279-13286
   Abstract »    Full Text »    PDF »
Nerve Growth Factor Accelerates Seizure Development, Enhances Mossy Fiber Sprouting, and Attenuates Seizure-Induced Decreases in Neuronal Density in the Kindling Model of Epilepsy.
B. Adams, M. Sazgar, P. Osehobo, C. E. E. M. Van der Zee, J. Diamond, M. Fahnestock, and R. J. Racine (1997)
J. Neurosci. 17, 5288-5296
   Abstract »    Full Text »    PDF »
Absence of a Persistently Elevated 37 kDa Fos-Related Antigen and AP-1-Like DNA-Binding Activity in the Brains of Kainic Acid-Treated fosB Null Mice.
A. Mandelzys, M. A. Gruda, R. Bravo, and J. I. Morgan (1997)
J. Neurosci. 17, 5407-5415
   Abstract »    Full Text »    PDF »
Expression of LIM Protein Genes Lmo1, Lmo2, and Lmo3 in Adult Mouse Hippocampus and Other Forebrain Regions: Differential Regulation by Seizure Activity.
G. L. Hinks, B. Shah, S. J. French, L. S. Campos, K. Staley, J. Hughes, and M. V. Sofroniew (1997)
J. Neurosci. 17, 5549-5559
   Abstract »    Full Text »    PDF »
Activity-Dependent Expression of NT-3 in Muscle Cells in Culture: Implications in the Development of Neuromuscular Junctions.
K. Xie, T. Wang, P. Olafsson, K. Mizuno, and B. Lu (1997)
J. Neurosci. 17, 2947-2958
   Abstract »    Full Text »    PDF »
Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport.
J. M. Conner, J. C. Lauterborn, Q. Yan, C. M. Gall, and S. Varon (1997)
J. Neurosci. 17, 2295-2313
   Abstract »    Full Text »    PDF »
NMDA Receptor Dependence of Kindling and Mossy Fiber Sprouting: Evidence that the NMDA Receptor Regulates Patterning of Hippocampal Circuits in the Adult Brain.
T. Sutula, J. Koch, G. Golarai, Y. Watanabe, and J. O. McNamara (1996)
J. Neurosci. 16, 7398-7406
   Abstract »    Full Text »    PDF »
Neurotrophin Effects on Survival and Expression of Cholinergic Properties in Cultured Rat Septal Neurons under Normal and Stress Conditions.
D. Nonner, E. F. Barrett, and J. N. Barrett (1996)
J. Neurosci. 16, 6665-6675
   Abstract »    Full Text »    PDF »
Upregulation of BDNF mRNA Expression in the Barrel Cortex of Adult Mice after Sensory Stimulation.
N. Rocamora, E. Welker, M. Pascual, and E. Soriano (1996)
J. Neurosci. 16, 4411-4419
   Abstract »    Full Text »    PDF »
Low Levels of Nerve Growth Factor in Cerebrospinal Fluid of Children With Rett Syndrome.
R. Lappalainen, D. Lindholm, and R. Riikonen (1996)
J Child Neurol 11, 296-300
   Abstract »    PDF »
Null Mutation of c-fos Impairs Structural and Functional Plasticities in the Kindling Model of Epilepsy.
Y. Watanabe, R. S. Johnson, L. S. Butler, D. K. Binder, B. M. Spiegelman, V. E. Papaioannou, and J. O. McNamara (1996)
J. Neurosci. 16, 3827-3836
   Abstract »    Full Text »    PDF »
Expression of NGF and NT3 mRNAs in Hippocampal Interneurons Innervated by the GABAergic Septohippocampal Pathway.
N. Rocamora, M. Pascual, L. Acsady, L. de Lecea, T. F. Freund, and E. Soriano (1996)
J. Neurosci. 16, 3991-4004
   Abstract »    Full Text »    PDF »
Neurotrophins in Cortical Development.
D.R. Riddle, A.K. McAllister, D.C. Lo, and L.C. Katz (1996)
Cold Spring Harb Symp Quant Biol 61, 85-93
   Abstract »    PDF »
A 13-Mer Peptide of a Brain Injury-derived Protein Supports Neuronal Survival and Rescues Neurons from Injury Caused by Glutamate.
T. Hama, A. Ogura, A. Omori, M. Murayama, M. Kubota, M. Sekiguchi, M. Ishiguro, M. Maruyama, H. Hatanaka, and K. Sato (1995)
J. Biol. Chem. 270, 29067-29070
   Abstract »    Full Text »    PDF »
Neurotrophins and Neuronal Plasticity.
H. Thoenen (1995)
Science 270, 593-598
   Abstract »    PDF »
Calcium signaling in neurons: molecular mechanisms and cellular consequences.
A Ghosh and M. Greenberg (1995)
Science 268, 239-247
   Abstract »    PDF »
Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF.
R. Cabelli, A Hohn, and C. Shatz (1995)
Science 267, 1662-1666
   Abstract »    PDF »
GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro.
B Berninger, S Marty, F Zafra, M da Penha Berzaghi, H Thoenen, and D Lindholm (1995)
Development 121, 2327-2335
   Abstract »    PDF »
Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development.
V. Buchman, M Sporn, and A. Davies (1994)
Development 120, 1621-1629
   Abstract »    PDF »
A stimulus paradigm inducing long-term desensitization of AMPA receptors evokes a specific increase in BDNF mRNA in cerebellar slices..
M Yuzaki, T Furuichi, K Mikoshiba, and Y Kagawa (1994)
Learn. Mem. 1, 230-242
   Abstract »    PDF »
Abnormal Reinnervation as a Basis for Schizophrenia: A Hypothesis.
J. R. Stevens (1992)
Arch Gen Psychiatry 49, 238-243
   Abstract »    PDF »
Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons.
H. Phillips, J. Hains, G. Laramee, A Rosenthal, and J. Winslow (1990)
Science 250, 290-294
   Abstract »    PDF »
Activity-dependent Regulation of Gene Expression in Adult Monkey Visual Cortex.
E.G. Jones, D.L. Benson, S.H.C. Hendry, and P.J. Isackson (1990)
Cold Spring Harb Symp Quant Biol 55, 481-490
   Abstract »    PDF »
Regulation of proenkephalin by Fos and Jun.
J. Sonnenberg, F. Rauscher 3rd, J. Morgan, and T Curran (1989)
Science 246, 1622-1625
   Abstract »    PDF »
Identification and Molecular Cloning of a Novel Brain-specific Receptor Protein That Binds to Brain Injury-derived Neurotrophic Peptide. POSSIBLE ROLE FOR NEURONAL SURVIVAL.
T. Hama, M. Maruyama, R. Katoh-Semba, M. Takizawa, M. Iwashima, and K. Nara (2001)
J. Biol. Chem. 276, 31929-31935
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)