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Science 18 August 1989: Vol. 245. no. 4919, pp. 752 - 755 DOI: 10.1126/science.2475908
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Articles
Science, Vol 245, Issue 4919, 752-755
Copyright © 1989 by American Association for the Advancement of Science
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth
PW Finch,
JS Rubin,
T Miki,
D Ron,
and
SA Aaronson
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript was present in stromal cells derived from epithelial tissues. By comparison with the expression of other epithelial cell mitogens, only KGF, among known human growth factors, has the properties of a stromal mediator of epithelial cell proliferation.
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- Keratinocyte Growth Factor Modulates Alveolar Epithelial Cell Phenotype In Vitro: Expression of Aquaporin 5 .
- Z. Borok, R. L. Lubman, S. I. Danto, X.-L. Zhang, S. M. Zabski, L. S. King, D. M. Lee, P. Agre, and E. D. Crandall (1998)
Am. J. Respir. Cell Mol. Biol.
18, 554-561
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- Growth factor involvement in progression of prostate cancer.
- P. J. Russell, S. Bennett, and P. Stricker (1998)
Clin. Chem.
44, 705-723
| Abstract »
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- Receptor-mediated endocytosis of keratinocyte growth factor.
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J. Cell Sci.
111, 3517-3527
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- Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans.
- D. B. Zimonjic, M. J. Kelley, J. S. Rubin, S. A. Aaronson, and N. C. Popescu (1997)
PNAS
94, 11461-11465
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- Keratinocyte Growth Factor Expression in the Mesenchymal Cells of Human Amnion.
- M. L. Casey and P. C. MacDonald (1997)
J. Clin. Endocrinol. Metab.
82, 3319-3323
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- Cell Type-specific Inhibition of Keratinocyte Collagenase-1 Expression by Basic Fibroblast Growth Factor and Keratinocyte Growth Factor. A COMMON RECEPTOR PATHWAY.
- B. K. Pilcher, J. Gaither-Ganim, W. C. Parks, and H. G. Welgus (1997)
J. Biol. Chem.
272, 18147-18154
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- Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.
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PNAS
94, 6770-6775
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- Biological Roles of Fibroblast Growth Factor-2.
- A. Bikfalvi, S. Klein, G. Pintucci, and D. B. Rifkin (1997)
Endocr. Rev.
18, 26-45
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- The Human Homologue of the Yeast CHL1 Gene Is a Novel Keratinocyte Growth Factor-regulated Gene.
- S. Frank and S. Werner (1996)
J. Biol. Chem.
271, 24337-24340
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- Expression of Keratinocyte Growth Factor in Periapical Lesions.
- Z. Gao, C.M. Flaitz, and I.C. Mackenzie (1996)
Journal of Dental Research
75, 1658-1663
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- Receptor Specificity of the Fibroblast Growth Factor Family.
- D. M. Ornitz, J. Xu, J. S. Colvin, D. G. McEwen, C. A. MacArthur, F. Coulier, G. Gao, and M. Goldfarb (1996)
J. Biol. Chem.
271, 15292-15297
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- Keratinocyte Growth Factor Induces Granulation Tissue in Ischemic Dermal Wounds: Importance of Epithelial-Mesenchymal Cell Interactions.
- L. Wu, G. F. Pierce, R. D. Galiano, and T. A. Mustoe (1996)
Arch Surg
131, 660-666
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- Hepatocyte Growth Factor (HGF)/NK1 Is a Naturally Occurring HGF/Scatter Factor Variant with Partial Agonist/Antagonist Activity.
- V. Cioce, K. G. Csaky, A. M.-L. Chan, D. P. Bottaro, W. G. Taylor, R. Jensen, S. A. Aaronson, and J. S. Rubin (1996)
J. Biol. Chem.
271, 13110-13115
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- Keratinocyte Growth Factor Inhibits Cross-linked Envelope Formation and Nucleosomal Fragmentation in Cultured Human Keratinocytes.
- M. D. Hines and B. L. Allen-Hoffmann (1996)
J. Biol. Chem.
271, 6245-6251
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- Expression of Messenger RNA for Keratinocyte Growth Factor in Human Cholesteatoma.
- H. Kojima, A. Matsuhisa, M. Shiwa, Y. Kamide, M. Nakamura, T. Ohno, and H. Moriyama (1996)
Arch Otolaryngol Head Neck Surg
122, 157-160
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- Keratinocyte growth factor is required for hair development but not for wound healing..
- L Guo, L Degenstein, and E Fuchs (1996)
Genes & Dev.
10, 165-175
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- Chimeric Molecules between Keratinocyte Growth Factor and Basic Fibroblast Growth Factor Define Domains That Confer Receptor Binding Specificities.
- R. Reich-Slotky, E. Shaoul, B. Berman, G. Graziani, and D. Ron (1995)
J. Biol. Chem.
270, 29813-29818
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- Glu-96 of Basic Fibroblast Growth Factor Is Essential for High Affinity Receptor Binding.
- H. Zhu, K. Ramnarayan, J. Anchin, W. Y. Miao, A. Sereno, L. Millman, J. Zheng, V. N. Balaji, and M. E. Wolff (1995)
J. Biol. Chem.
270, 21869-21874
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- A Human Keratinocyte Cell Line Produces Two Autocrine Growth Inhibitors, Transforming Growth Factor-[IMAGE] and Insulin-like Growth Factor Binding Protein-6, in a Calcium- and Cell Density-dependent Manner.
- M. Kato, A. Ishizaki, U. Hellman, C. Wernstedt, M. Kyogoku, K. Miyazono, C.-H. Heldin, and K. Funa (1995)
J. Biol. Chem.
270, 12373-12379
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- Ligand-specific Structural Domains in the Fibroblast Growth Factor Receptor.
- F. Wang, M. Kan, J. Xu, G. Yan, and W. L. McKeehan (1995)
J. Biol. Chem.
270, 10222-10230
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- Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice..
- W Cui, D J Fowlis, F M Cousins, E Duffie, S Bryson, A Balmain, and R J Akhurst (1995)
Genes & Dev.
9, 945-955
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- Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells.
- J. Soriano, M. Pepper, T Nakamura, L Orci, and R Montesano (1995)
J. Cell Sci.
108, 413-430
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- Modulation of epithelial cell growth by intraepithelial gamma delta T cells.
- R Boismenu and W. Havran (1994)
Science
266, 1253-1255
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- The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.
- S Werner, H Smola, X Liao, M. Longaker, T Krieg, P. Hofschneider, and L. Williams (1994)
Science
266, 819-822
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- Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture.
- Y. Kinoshita, C. Kinoshita, J. G. Heuer, and M. Bothwell (1993)
Development
119, 943-956
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