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Science 18 August 1989:
Vol. 245. no. 4919, pp. 752 - 755
DOI: 10.1126/science.2475908

Articles

Science, Vol 245, Issue 4919, 752-755
Copyright © 1989 by American Association for the Advancement of Science


articles

Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth

PW Finch, JS Rubin, T Miki, D Ron, and SA Aaronson

Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.

Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript was present in stromal cells derived from epithelial tissues. By comparison with the expression of other epithelial cell mitogens, only KGF, among known human growth factors, has the properties of a stromal mediator of epithelial cell proliferation.


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Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung.
L. Charafeddine, C. T. D'Angio, J. L. Richards, B. R. Stripp, J. N. Finkelstein, C. C. Orlowski, M. B. LoMonaco, A. Paxhia, and R. M. Ryan (1999)
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Keratinocyte Growth Factor Down-regulates Expression of the Sucrase-Isomaltase Gene in Caco-2 Intestinal Epithelial Cells.
J. Zhou, K. Wu, C. L. Fernandes, A. L. Cheng, and P. W. Finch (1998)
J. Biol. Chem. 273, 33367-33373
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Keratinocyte Growth Factor Administered Before Conditioning Ameliorates Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation in Mice.
A. Panoskaltsis-Mortari, D. L. Lacey, D. A. Vallera, and B. R. Blazar (1998)
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Gut-Trophic Effects of Keratinocyte Growth Factor in Rat Small Intestine and Colon During Enteral Refeeding.
C. F. Estivariz, C. R. Jonas, L. H. Gu, E. E. Diaz, T. M. Wallace, R. R. Pascal, C. L. Farrell, and T. R. Ziegler (1998)
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Breast and Prostate Cancer: An Analysis of Common Epidemiological, Genetic, and Biochemical Features.
C. Lopez-Otin and E. P. Diamandis (1998)
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Z. Borok, S. I. Danto, R. L. Lubman, Y. Cao, M. C. Williams, and E. D. Crandall (1998)
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Keratinocyte Growth Factor Expression by the Bovine Corpus Luteum.
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J. Biol. Chem. 272, 18147-18154
   Abstract »    Full Text »    PDF »
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.
P. W. Finch, X. He, M. J. Kelley, A. Uren, R. P. Schaudies, N. C. Popescu, S. Rudikoff, S. A. Aaronson, H. E. Varmus, and J. S. Rubin (1997)
PNAS 94, 6770-6775
   Abstract »    Full Text »    PDF »
Biological Roles of Fibroblast Growth Factor-2.
A. Bikfalvi, S. Klein, G. Pintucci, and D. B. Rifkin (1997)
Endocr. Rev. 18, 26-45
   Abstract »    Full Text »
The Human Homologue of the Yeast CHL1 Gene Is a Novel Keratinocyte Growth Factor-regulated Gene.
S. Frank and S. Werner (1996)
J. Biol. Chem. 271, 24337-24340
   Abstract »    Full Text »    PDF »
Expression of Keratinocyte Growth Factor in Periapical Lesions.
Z. Gao, C.M. Flaitz, and I.C. Mackenzie (1996)
Journal of Dental Research 75, 1658-1663
   Abstract »    PDF »
Receptor Specificity of the Fibroblast Growth Factor Family.
D. M. Ornitz, J. Xu, J. S. Colvin, D. G. McEwen, C. A. MacArthur, F. Coulier, G. Gao, and M. Goldfarb (1996)
J. Biol. Chem. 271, 15292-15297
   Abstract »    Full Text »    PDF »
Keratinocyte Growth Factor Induces Granulation Tissue in Ischemic Dermal Wounds: Importance of Epithelial-Mesenchymal Cell Interactions.
L. Wu, G. F. Pierce, R. D. Galiano, and T. A. Mustoe (1996)
Arch Surg 131, 660-666
   Abstract »    PDF »
Hepatocyte Growth Factor (HGF)/NK1 Is a Naturally Occurring HGF/Scatter Factor Variant with Partial Agonist/Antagonist Activity.
V. Cioce, K. G. Csaky, A. M.-L. Chan, D. P. Bottaro, W. G. Taylor, R. Jensen, S. A. Aaronson, and J. S. Rubin (1996)
J. Biol. Chem. 271, 13110-13115
   Abstract »    Full Text »    PDF »
Keratinocyte Growth Factor Inhibits Cross-linked Envelope Formation and Nucleosomal Fragmentation in Cultured Human Keratinocytes.
M. D. Hines and B. L. Allen-Hoffmann (1996)
J. Biol. Chem. 271, 6245-6251
   Abstract »    Full Text »    PDF »
Expression of Messenger RNA for Keratinocyte Growth Factor in Human Cholesteatoma.
H. Kojima, A. Matsuhisa, M. Shiwa, Y. Kamide, M. Nakamura, T. Ohno, and H. Moriyama (1996)
Arch Otolaryngol Head Neck Surg 122, 157-160
   Abstract »    PDF »
Keratinocyte growth factor is required for hair development but not for wound healing..
L Guo, L Degenstein, and E Fuchs (1996)
Genes & Dev. 10, 165-175
   Abstract »    PDF »
Chimeric Molecules between Keratinocyte Growth Factor and Basic Fibroblast Growth Factor Define Domains That Confer Receptor Binding Specificities.
R. Reich-Slotky, E. Shaoul, B. Berman, G. Graziani, and D. Ron (1995)
J. Biol. Chem. 270, 29813-29818
   Abstract »    Full Text »    PDF »
Glu-96 of Basic Fibroblast Growth Factor Is Essential for High Affinity Receptor Binding.
H. Zhu, K. Ramnarayan, J. Anchin, W. Y. Miao, A. Sereno, L. Millman, J. Zheng, V. N. Balaji, and M. E. Wolff (1995)
J. Biol. Chem. 270, 21869-21874
   Abstract »    Full Text »    PDF »
A Human Keratinocyte Cell Line Produces Two Autocrine Growth Inhibitors, Transforming Growth Factor-[IMAGE] and Insulin-like Growth Factor Binding Protein-6, in a Calcium- and Cell Density-dependent Manner.
M. Kato, A. Ishizaki, U. Hellman, C. Wernstedt, M. Kyogoku, K. Miyazono, C.-H. Heldin, and K. Funa (1995)
J. Biol. Chem. 270, 12373-12379
   Abstract »    Full Text »    PDF »
Ligand-specific Structural Domains in the Fibroblast Growth Factor Receptor.
F. Wang, M. Kan, J. Xu, G. Yan, and W. L. McKeehan (1995)
J. Biol. Chem. 270, 10222-10230
   Abstract »    Full Text »    PDF »
Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice..
W Cui, D J Fowlis, F M Cousins, E Duffie, S Bryson, A Balmain, and R J Akhurst (1995)
Genes & Dev. 9, 945-955
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Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells.
J. Soriano, M. Pepper, T Nakamura, L Orci, and R Montesano (1995)
J. Cell Sci. 108, 413-430
   Abstract »    PDF »
Modulation of epithelial cell growth by intraepithelial gamma delta T cells.
R Boismenu and W. Havran (1994)
Science 266, 1253-1255
   Abstract »    PDF »
The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.
S Werner, H Smola, X Liao, M. Longaker, T Krieg, P. Hofschneider, and L. Williams (1994)
Science 266, 819-822
   Abstract »    PDF »
Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture.
Y. Kinoshita, C. Kinoshita, J. G. Heuer, and M. Bothwell (1993)
Development 119, 943-956
   Abstract »    PDF »



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