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Science 18 August 1989:
Vol. 245. no. 4919, pp. 740 - 743
DOI: 10.1126/science.2475907
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Articles

Science, Vol 245, Issue 4919, 740-743
Copyright © 1989 by American Association for the Advancement of Science

articles

Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis

H Wolfes, K Kogawa, CF Millette, and GM Cooper

Dana-Farber Cancer Institute, Boston, MA.

The expression of proto-oncogenes representative of several functional categories has been investigated during development of mouse male germ cells. The c-raf proto-oncogene and three members of the c-ras gene family were expressed in mitotically active stem cells, throughout the prophase of meiosis and to varying extents in post-meiotic cell types. In contrast, the nuclear proto-oncogenes c-fos, c-jun, and c-myc were specifically expressed at high levels in type B spermatogonia. High levels of c-myc and c-jun RNAs were also detected in spermatocytes early in the prophase of meiosis. The type B spermatogonia represent the last mitotic cell division before entry into meiotic prophase; therefore, these nuclear proto-oncogenes may be involved in altering programs of gene expression at this developmental transition.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Impact of the Chemotherapy Cocktail Used to Treat Testicular Cancer on the Gene Expression Profile of Germ Cells from Male Brown-Norway Rats.
G. Delbes, D. Chan, P. Pakarinen, J. M. Trasler, B. F. Hales, and B. Robaire (2009)
Biol Reprod 80, 320-327
   Abstract »    Full Text »    PDF »
The Novel Estrogen Receptor, G Protein-Coupled Receptor 30, Mediates the Proliferative Effects Induced by 17{beta}-Estradiol on Mouse Spermatogonial GC-1 Cell Line.
R. Sirianni, A. Chimento, C. Ruggiero, A. De Luca, R. Lappano, S. Ando, M. Maggiolini, and V. Pezzi (2008)
Endocrinology 149, 5043-5051
   Abstract »    Full Text »    PDF »
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression.
B. Li, M. Nair, D. R. Mackay, V. Bilanchone, M. Hu, M. Fallahi, H. Song, Q. Dai, P. E. Cohen, and X. Dai (2005)
Development 132, 1463-1473
   Abstract »    Full Text »    PDF »
Identification of Ras and Its Downstream Signaling Elements and Their Potential Role in Hamster Sperm Motility.
S. K. NagDas, V. P. Winfrey, and G. E. Olson (2002)
Biol Reprod 67, 1058-1066
   Abstract »    Full Text »    PDF »


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