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Science 18 August 1989:
Vol. 245. no. 4919, pp. 718 - 725
DOI: 10.1126/science.2672330

Articles

Science, Vol 245, Issue 4919, 718-725
Copyright © 1989 by American Association for the Advancement of Science


articles

Morphogenesis of the polarized epithelial cell phenotype

E Rodriguez-Boulan and WJ Nelson

Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021.

Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelial cells (the trophectoderm) is the first overt sign of cellular differentiation in early embryonic development. In the adult, polarized epithelial cells line all body cavities and occur in tissues that carry out specialized vectorial transport functions of absorption and secretion. The generation of this phenotype is a multistage process requiring extracellular cues and the reorganization of proteins in the cytoplasm and on the plasma membrane; once established, the phenotype is maintained by the segregation and retention of specific proteins and lipids in distinct apical and basal-lateral plasma membrane domains.


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Y.-T. Chen, D. B. Stewart, and W. J. Nelson (1999)
J. Cell Biol. 144, 687-699
   Abstract »    Full Text »    PDF »
Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells - a combination of apical sorting and retention in plasma membrane protrusions.
D Corbeil, K Roper, M. Hannah, A Hellwig, and W. Huttner (1999)
J. Cell Sci. 112, 1023-1033
   Abstract »    PDF »
Membrane receptor location defines receptor interaction with signaling proteins in a polarized epithelium.
K. Amsler and S. K. Kuwada (1999)
Am J Physiol Cell Physiol 276, C91-C101
   Abstract »    Full Text »    PDF »
Biogenesis of Polarized Epithelial Cells During Kidney Development In Situ: Roles of E-Cadherin-mediated Cell-Cell Adhesion and Membrane Cytoskeleton Organization.
P. A. Piepenhagen and W. J. Nelson (1998)
Mol. Biol. Cell 9, 3161-3177
   Abstract »    Full Text »
Tyrosine-based Membrane Protein Sorting Signals Are Differentially Interpreted by Polarized Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells.
D. L. Roush, C. J. Gottardi, H. Y. Naim, M. G. Roth, and M. J. Caplan (1998)
J. Biol. Chem. 273, 26862-26869
   Abstract »    Full Text »    PDF »
Modeling cell volume regulation in nonexcitable cells: the roles of the Na+ pump and of cotransport systems.
J. A. Hernandez and E. Cristina (1998)
Am J Physiol Cell Physiol 275, C1067-C1080
   Abstract »    Full Text »    PDF »
Annexin XIIIb Associates with Lipid Microdomains to Function in Apical Delivery.
F. Lafont, S. Lecat, P. Verkade, and K. Simons (1998)
J. Cell Biol. 142, 1413-1427
   Abstract »    Full Text »    PDF »
Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion.
S. Gopalakrishnan, N. Raman, S. J. Atkinson, and J. A. Marrs (1998)
Am J Physiol Cell Physiol 275, C798-C809
   Abstract »    Full Text »    PDF »
Involvement of Galpha i2 in the Maintenance and Biogenesis of Epithelial Cell Tight Junctions.
C. Saha, S. K. Nigam, and B. M. Denker (1998)
J. Biol. Chem. 273, 21629-21633
   Abstract »    Full Text »    PDF »
Apical Polarity of N-CAM and EMMPRIN in Retinal Pigment Epithelium Resulting from Suppression of Basolateral Signal Recognition.
A. D. Marmorstein, Y. C. Gan, V. L. Bonilha, S. C. Finnemann, K. G. Csaky, and E. Rodriguez-Boulan (1998)
J. Cell Biol. 142, 697-710
   Abstract »    Full Text »    PDF »
Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor-induced Adherens Junction Disassembly.
S. Potempa and A. J. Ridley (1998)
Mol. Biol. Cell 9, 2185-2200
   Abstract »    Full Text »
Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases.
T.-S. Jou, E. E. Schneeberger, and W. James Nelson (1998)
J. Cell Biol. 142, 101-115
   Abstract »    Full Text »    PDF »
Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin.
M. Furuse, K. Fujita, T. Hiiragi, K. Fujimoto, and S. Tsukita (1998)
J. Cell Biol. 141, 1539-1550
   Abstract »    Full Text »    PDF »
Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components.
T. Harder, P. Scheiffele, P. Verkade, and K. Simons (1998)
J. Cell Biol. 141, 929-942
   Abstract »    Full Text »    PDF »
Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture.
C. F. Verkoelen, B. G. Van Der Boom, A. B. Houtsmuller, F. H. Schroder, and J. C. Romijn (1998)
Am J Physiol Renal Physiol 274, F958-F965
   Abstract »    Full Text »    PDF »
Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions.
M. Saitou, K. Fujimoto, Y. Doi, M. Itoh, T. Fujimoto, M. Furuse, H. Takano, T. Noda, and S. Tsukita (1998)
J. Cell Biol. 141, 397-408
   Abstract »    Full Text »    PDF »
Fluid-Phase Markers in the Basolateral Endocytic Pathway Accumulate in Response to the Actin Assembly-promoting Drug Jasplakinolide.
W. Shurety, N. L. Stewart, and J. L. Stow (1998)
Mol. Biol. Cell 9, 957-975
   Abstract »    Full Text »
Apiconuclear Organization of Microtubules Does Not Specify Protein Delivery from the Trans-Golgi Network to Different Membrane Domains in Polarized Epithelial Cells.
K. K. Grindstaff, R. L. Bacallao, and W. J. Nelson (1998)
Mol. Biol. Cell 9, 685-699
   Abstract »    Full Text »
Suppression of tumorigenicity in an aggressive cervical carcinoma induced by protein zero, a nervous system IgCAM.
L. Spiryda and D. Colman (1998)
J. Cell Sci. 111, 3253-3260
   Abstract »    PDF »



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