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Science 18 August 1989: Vol. 245. no. 4919, pp. 718 - 725 DOI: 10.1126/science.2672330
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Articles
Science, Vol 245, Issue 4919, 718-725
Copyright © 1989 by American Association for the Advancement of Science
Morphogenesis of the polarized epithelial cell phenotype
E Rodriguez-Boulan
and
WJ Nelson
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021.
Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelial cells (the trophectoderm) is the first overt sign of cellular differentiation in early embryonic development. In the adult, polarized epithelial cells line all body cavities and occur in tissues that carry out specialized vectorial transport functions of absorption and secretion. The generation of this phenotype is a multistage process requiring extracellular cues and the reorganization of proteins in the cytoplasm and on the plasma membrane; once established, the phenotype is maintained by the segregation and retention of specific proteins and lipids in distinct apical and basal-lateral plasma membrane domains.
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- Basolateral Localization of the Caenorhabditis elegans Epidermal Growth Factor Receptor in Epithelial Cells by the PDZ Protein LIN-10.
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Mol. Biol. Cell
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- The zeta Isoform of 14-3-3 Proteins Interacts with the Third Intracellular Loop of Different alpha 2-Adrenergic Receptor Subtypes.
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- Constitutively Active Mitogen-activated Protein Kinase Kinase MEK1 Disrupts Morphogenesis and Induces an Invasive Phenotype in Madin-Darby Canine Kidney Epithelial Cells.
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- A PDZ-containing Scaffold Related to the Dystrophin Complex at the Basolateral Membrane of Epithelial Cells.
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- What keeps hepatocytes on the straight and narrow? Maintaining differentiated function in the liver.
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- Coupling Assembly of the E-Cadherin/{beta}-Catenin Complex to Efficient Endoplasmic Reticulum Exit and Basal-lateral Membrane Targeting of E-Cadherin in Polarized MDCK Cells.
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- Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells - a combination of apical sorting and retention in plasma membrane protrusions.
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- Membrane receptor location defines receptor interaction with signaling proteins in a polarized epithelium.
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- Biogenesis of Polarized Epithelial Cells During Kidney Development In Situ: Roles of E-Cadherin-mediated Cell-Cell Adhesion and Membrane Cytoskeleton Organization.
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- Tyrosine-based Membrane Protein Sorting Signals Are Differentially Interpreted by Polarized Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells.
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- Apical Polarity of N-CAM and EMMPRIN in Retinal Pigment Epithelium Resulting from Suppression of Basolateral Signal Recognition.
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- Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor-induced Adherens Junction Disassembly.
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- Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin.
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- Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components.
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- Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture.
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Am J Physiol Renal Physiol
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- Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions.
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- Fluid-Phase Markers in the Basolateral Endocytic Pathway Accumulate in Response to the Actin Assembly-promoting Drug Jasplakinolide.
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- Apiconuclear Organization of Microtubules Does Not Specify Protein Delivery from the Trans-Golgi Network to Different Membrane Domains in Polarized Epithelial Cells.
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