Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 11 August 1989:
Vol. 245. no. 4918, pp. 648 - 651
DOI: 10.1126/science.2569762
Prev | Table of Contents | Next

Articles

Science, Vol 245, Issue 4918, 648-651
Copyright © 1989 by American Association for the Advancement of Science

articles

NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model

SF Stasheff, WW Anderson, S Clark, and WA Wilson

Epilepsy Center, Veterans Administration Medical Center, Durham, NC 27705.

In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator.
A. D. Wickenden, J. L. Krajewski, B. London, P. K. Wagoner, W. A. Wilson, S. Clark, R. Roeloffs, G. McNaughton-Smith, and G. C. Rigdon (2008)
Mol. Pharmacol. 73, 977-986
   Abstract »    Full Text »    PDF »
NMDA Receptor Trafficking at Recurrent Synapses Stabilizes the State of the CA3 Network.
J. L. Hellier, D. R. Grosshans, S. J. Coultrap, J. P. Jones, P. Dobelis, M. D. Browning, and K. J. Staley (2007)
J Neurophysiol 98, 2818-2826
   Abstract »    Full Text »    PDF »
Voltage Imaging Reveals the CA1 Region at the CA2 Border as a Focus for Epileptiform Discharges and Long-Term Potentiation in Hippocampal Slices.
P. Y. Chang, P. E. Taylor, and M. B. Jackson (2007)
J Neurophysiol 98, 1309-1322
   Abstract »    Full Text »    PDF »
Molecular Signaling Mechanisms Underlying Epileptogenesis.
J. O. McNamara, Y. Z. Huang, and A. S. Leonard (2006)
Sci. STKE 2006, re12
   Abstract »    Full Text »    PDF »
Astrocytic Glutamate Is Not Necessary for the Generation of Epileptiform Neuronal Activity in Hippocampal Slices.
T. Fellin, M. Gomez-Gonzalo, S. Gobbo, G. Carmignoto, and P. G. Haydon (2006)
J. Neurosci. 26, 9312-9322
   Abstract »    Full Text »    PDF »
Comparable GABAergic Mechanisms of Hippocampal Seizurelike Activity in Posttetanic and Low-Mg2+ Conditions.
Y. Fujiwara-Tsukamoto, Y. Isomura, and M. Takada (2006)
J Neurophysiol 95, 2013-2019
   Abstract »    Full Text »    PDF »
Synaptic interactions between pyramidal cells and interneurone subtypes during seizure-like activity in the rat hippocampus.
Y. Fujiwara-Tsukamoto, Y. Isomura, K. Kaneda, and M. Takada (2004)
J. Physiol. 557, 961-979
   Abstract »    Full Text »    PDF »
Epileptiform activity in rat hippocampus strengthens excitatory synapses.
M. H. Abegg, N. Savic, M. U. Ehrengruber, R. A. McKinney, and B. H. Gahwiler (2004)
J. Physiol. 554, 439-448
   Abstract »    Full Text »    PDF »
Glutamatergic Propagation of GABAergic Seizure-Like Afterdischarge in the Hippocampus In Vitro.
Y. Isomura, Y. Fujiwara-Tsukamoto, and M. Takada (2003)
J Neurophysiol 90, 2746-2751
   Abstract »    Full Text »    PDF »
Synaptically Activated Cl- Accumulation Responsible for Depolarizing GABAergic Responses in Mature Hippocampal Neurons.
Y. Isomura, M. Sugimoto, Y. Fujiwara-Tsukamoto, S. Yamamoto-Muraki, J. Yamada, and A. Fukuda (2003)
J Neurophysiol 90, 2752-2756
   Abstract »    Full Text »    PDF »
Convulsant and Anticonvulsant Effects on Spontaneous CA3 Population Bursts.
A. S. Yee, J. M. Longacher, and K. J. Staley (2003)
J Neurophysiol 89, 427-441
   Abstract »    Full Text »    PDF »
NMDA Receptor Antagonists Disinhibit Rat Posterior Cingulate and Retrosplenial Cortices: A Potential Mechanism of Neurotoxicity.
Q. Li, S. Clark, D. V. Lewis, and W. A. Wilson (2002)
J. Neurosci. 22, 3070-3080
   Abstract »    Full Text »    PDF »
Statistical Model Relating CA3 Burst Probability to Recovery From Burst-Induced Depression at Recurrent Collateral Synapses.
K. J. Staley, J. S. Bains, A. Yee, J. Hellier, and J. M. Longacher (2001)
J Neurophysiol 86, 2736-2747
   Abstract »    Full Text »    PDF »
Epileptiform Discharges With In-Vivo-Like Features in Slices of Rat Piriform Cortex With Longitudinal Association Fibers.
R. Demir, L. B. Haberly, and M. B. Jackson (2001)
J Neurophysiol 86, 2445-2460
   Abstract »    Full Text »    PDF »
Decreased Glutamate Receptor 2 Expression and Enhanced Epileptogenesis in Immature Rat Hippocampus after Perinatal Hypoxia-Induced Seizures.
R. M. Sanchez, S. Koh, C. Rio, C. Wang, E. D. Lamperti, D. Sharma, G. Corfas, and F. E. Jensen (2001)
J. Neurosci. 21, 8154-8163
   Abstract »    Full Text »    PDF »
Glutamate Injury-Induced Epileptogenesis in Hippocampal Neurons: An In Vitro Model of Stroke-Induced "Epilepsy".
D. A. Sun, S. Sombati, and R. J. DeLorenzo (2001)
Stroke 32, 2344-2350
   Abstract »    Full Text »    PDF »
Characteristics of Plateau Activity During the Latent Period Prior to Epileptiform Discharges in Slices From Rat Piriform Cortex.
R. Demir, L. B. Haberly, and M. B. Jackson (2000)
J Neurophysiol 83, 1088-1098
   Abstract »    Full Text »    PDF »
Increased Detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy.
Y. Pu, Q.-F. Li, C.-M. Zeng, J. Gao, J. Qi, D.-X. Luo, S. Mahankali, P. T. Fox, and J.-H. Gao (2000)
AJNR Am. J. Neuroradiol. 21, 203-212
   Abstract »    Full Text »    PDF »
Sustained Plateau Activity Precedes and Can Generate Ictal-Like Discharges in Low-Cl- Medium in Slices from Rat Piriform Cortex.
R. Demir, L. B. Haberly, and M. B. Jackson (1999)
J. Neurosci. 19, 10738-10746
   Abstract »    Full Text »    PDF »
Persistent Increased DNA-Binding and Expression of Serum Response Factor Occur with Epilepsy-Associated Long-Term Plasticity Changes.
T. A. Morris, N. Jafari, A. C. Rice, O. Vasconcelos, and R. J. DeLorenzo (1999)
J. Neurosci. 19, 8234-8243
   Abstract »    Full Text »    PDF »
Sustained and Accelerating Activity at Two Discrete Sites Generate Epileptiform Discharges in Slices of Piriform Cortex.
R. Demir, L. B. Haberly, and M. B. Jackson (1999)
J. Neurosci. 19, 1294-1306
   Abstract »    Full Text »    PDF »
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
R. J. DeLorenzo, S. Pal, and S. Sombati (1998)
PNAS 95, 14482-14487
   Abstract »    Full Text »    PDF »
Changes in Mitochondrial Function Resulting from Synaptic Activity in the Rat Hippocampal Slice.
V. P. Bindokas, C. C. Lee, W. F. Colmers, and R. J. Miller (1998)
J. Neurosci. 18, 4570-4587
   Abstract »    Full Text »    PDF »
Neuropeptide Y Suppresses Epileptiform Activity in Rat Hippocampus In Vitro.
G. J. Klapstein and W. F. Colmers (1997)
J Neurophysiol 78, 1651-1661
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)