Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 11 August 1989:
Vol. 245. no. 4918, pp. 643 - 646
DOI: 10.1126/science.2474853

Articles

Science, Vol 245, Issue 4918, 643-646
Copyright © 1989 by American Association for the Advancement of Science


articles

The product of the mos proto-oncogene as a candidate "initiator" for oocyte maturation

N Sagata, I Daar, M Oskarsson, SD Showalter, and GF Vande Woude

BRI-Basic Research Program, National Cancer Institute, Frederick Cancer Research Facility, MD 21701.

The endogenous c-mos product, pp39mos, is required for progesterone-induced meiotic maturation in Xenopus oocytes. Treatment of oocytes with progesterone induced a rapid increase in pp39mos that preceded both the activation of maturation promoting factor (MPF) and germinal vesicle breakdown (GVBD). Microinjection of synthetic mos RNA into oocytes activated MPF and induced GVBD in the absence of progesterone. Thus, the mos proto-oncogene product may qualify as a candidate "initiator" protein of MPF and is at least one of the "triggers" for G2 to M transition.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanisms Regulating Oocyte Meiotic Resumption: Roles of Mitogen-Activated Protein Kinase.
C.-G. Liang, Y.-Q. Su, H.-Y. Fan, H. Schatten, and Q.-Y. Sun (2007)
Mol. Endocrinol. 21, 2037-2055
   Abstract »    Full Text »    PDF »
Mechanistic studies of the mitotic activation of mos..
J. Yue and J. E. Ferrell Jr (2006)
Mol. Cell. Biol. 26, 5300-5309
   Abstract »    Full Text »    PDF »
Steroid-Induced Oocyte Maturation in Atlantic Croaker (Micropogonias undulatus) Is Dependent on Activation of the Phosphatidylinositol 3-Kinase/Akt Signal Transduction Pathway.
M. C. Pace and P. Thomas (2005)
Biol Reprod 73, 988-996
   Abstract »    Full Text »    PDF »
Feasibility of a Nylon-Mesh Holder for Vitrification of Bovine Germinal Vesicle Oocytes in Subsequent Production of Viable Blastocysts.
Y. Abe, K. Hara, H. Matsumoto, J. Kobayashi, H. Sasada, H. Ekwall, H. Rodriguez-Martinez, and E. Sato (2005)
Biol Reprod 72, 1416-1420
   Abstract »    Full Text »    PDF »
Meiotic progression of isolated mouse spermatocytes under simulated microgravity.
S. Di Agostino, F. Botti, A. Di Carlo, C. Sette, and R. Geremia (2004)
Reproduction 128, 25-32
   Abstract »    Full Text »    PDF »
Testicular Activity of Mos in the Frog, Rana esculenta: A New Role in Spermatogonial Proliferation.
D. Ferrara, C. Palmiero, M. Branno, R. Pierantoni, and S. Minucci (2004)
Biol Reprod 70, 1782-1789
   Abstract »    Full Text »    PDF »
Maturation-Promoting Factor Governs Mitogen-Activated Protein Kinase Activation and Interphase Suppression During Meiosis of Rat Oocytes.
L. B.-Y. Josefsberg, D. Galiani, S. Lazar, O. Kaufman, R. Seger, and N. Dekel (2003)
Biol Reprod 68, 1282-1290
   Abstract »    Full Text »    PDF »
Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs.
B. J. Tunquist and J. L. Maller (2003)
Genes & Dev. 17, 683-710
   Full Text »    PDF »
SNT1/FRS2 Mediates Germinal Vesicle Breakdown Induced by an Activated FGF Receptor1 in Xenopus Oocytes.
K. Mood, R. Friesel, and I. O. Daar (2002)
J. Biol. Chem. 277, 33196-33204
   Abstract »    Full Text »    PDF »
cAMP-Dependent PKA Negatively Regulates Polyadenylation of c-mos mRNA in Rat Oocytes.
S. Lazar, D. Galiani, and N. Dekel (2002)
Mol. Endocrinol. 16, 331-341
   Abstract »    Full Text »    PDF »
A new role for Mos in Xenopus oocyte maturation: targeting Myt1 independently of MAPK.
M. Peter, J.-C. Labbe, M. Doree, and E. Mandart (2002)
Development 129, 2129-2139
   Abstract »    Full Text »    PDF »
The MAPK pathway triggers activation of Nek2 during chromosome condensation in mouse spermatocytes.
S. Di Agostino, P. Rossi, R. Geremia, and C. Sette (2002)
Development 129, 1715-1727
   Abstract »    Full Text »    PDF »
New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation.
H. Hochegger, A. Klotzbucher, J. Kirk, M. Howell, K. le Guellec, K. Fletcher, T. Duncan, M. Sohail, and T. Hunt (2001)
Development 128, 3795-3807
   Abstract »    Full Text »    PDF »
Cyclin B/cdc2 Induces c-Mos Stability by Direct Phosphorylation in Xenopus Oocytes.
A. Castro, M. Peter, L. Magnaghi-Jaulin, S. Vigneron, S. Galas, T. Lorca, and J.-C. Labbe (2001)
Mol. Biol. Cell 12, 2660-2671
   Abstract »    Full Text »    PDF »
The Polo-like Kinase Plx1 Is Required for Activation of the Phosphatase Cdc25C and Cyclin B-Cdc2 in Xenopus Oocytes.
Y.-W. Qian, E. Erikson, F. E. Taieb, and J. L. Maller (2001)
Mol. Biol. Cell 12, 1791-1799
   Abstract »    Full Text »    PDF »
c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes.
K. Tachibana, D. Tanaka, T. Isobe, and T. Kishimoto (2000)
PNAS 97, 14301-14306
   Abstract »    Full Text »    PDF »
Ca2+ current activity decreases during meiotic progression in bovine oocytes.
E. Tosti, R. Boni, and A. Cuomo (2000)
Am J Physiol Cell Physiol 279, C1795-C1800
   Abstract »    Full Text »    PDF »
Progesterone regulates the accumulation and the activation of Eg2 kinase in Xenopus oocytes.
M Frank-Vaillant, O Haccard, C Thibier, R Ozon, Y Arlot-Bonnemains, C Prigent, and C Jessus (2000)
J. Cell Sci. 113, 1127-1138
   Abstract »    PDF »
Activation of the Mitogen-activated Protein Kinase ERK1 during Meiotic Progression of Mouse Pachytene Spermatocytes.
C. Sette, M. Barchi, A. Bianchini, M. Conti, P. Rossi, and R. Geremia (1999)
J. Biol. Chem. 274, 33571-33579
   Abstract »    Full Text »    PDF »
Distinct, Constitutively Active MAPK Phosphatases Function in Xenopus Oocytes: Implications for p42 MAPK Regulation In Vivo.
M. L. Sohaskey and J. E. Ferrell Jr. (1999)
Mol. Biol. Cell 10, 3729-3743
   Abstract »    Full Text »
Two Distinct Mechanisms Control the Accumulation of Cyclin B1 and Mos in Xenopus Oocytes in Response to Progesterone.
M. Frank-Vaillant, C. Jessus, R. Ozon, J. L. Maller, and O. Haccard (1999)
Mol. Biol. Cell 10, 3279-3288
   Abstract »    Full Text »
A p90rsk Mutant Constitutively Interacting with MAP Kinase Uncouples MAP Kinase from p34cdc2/Cyclin B Activation in Xenopus Oocytes.
A.-C. Gavin, A. N. Ainle, E. Chierici, M. Jones, and A. R. Nebreda (1999)
Mol. Biol. Cell 10, 2971-2986
   Abstract »    Full Text »
A novel p34cdc2-binding and activating p r o t e i n that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes.
I. Ferby, M. Blazquez, A. Palmer, R. Eritja, and A. R. Nebreda (1999)
Genes & Dev. 13, 2177-2189
   Abstract »    Full Text »
Estrogen Actions in the Central Nervous System.
B. S. McEwen and S. E. Alves (1999)
Endocr. Rev. 20, 279-307
   Abstract »    Full Text »
Cytoplasmic Polyadenylation in Development and Beyond.
J. D. Richter (1999)
Microbiol. Mol. Biol. Rev. 63, 446-456
   Abstract »    Full Text »    PDF »
M Phase Phosphorylation of Cytoplasmic Dynein Intermediate Chain and p150Glued.
C.-Y. F. Huang, C.-P. B. Chang, C.-L. Huang, and J. E. Ferrell Jr. (1999)
J. Biol. Chem. 274, 14262-14269
   Abstract »    Full Text »    PDF »
p70S6K Controls Selective mRNA Translation during Oocyte Maturation and Early Embryogenesis in Xenopus laevis.
M. S. Schwab, S. H. Kim, N. Terada, C. Edfjall, S. C. Kozma, G. Thomas, and J. L. Maller (1999)
Mol. Cell. Biol. 19, 2485-2494
   Abstract »    Full Text »    PDF »
The Mitogen-Activated Protein Kinase Signaling Pathway Stimulates Mos mRNA Cytoplasmic Polyadenylation during Xenopus Oocyte Maturation.
E. L. Howard, A. Charlesworth, J. Welk, and A. M. MacNicol (1999)
Mol. Cell. Biol. 19, 1990-1999
   Abstract »    Full Text »    PDF »
Identification and Cloning of Xp95, a Putative Signal Transduction Protein in Xenopus Oocytes.
S. Che, H. M. El-Hodiri, C.-F. Wu, M. Nelman-Gonzalez, M. M. Weil, L. D. Etkin, R. B. Clark, and J. Kuang (1999)
J. Biol. Chem. 274, 5522-5531
   Abstract »    Full Text »    PDF »
Control of G2/M Transition in Xenopus by a Member of the p21-activated Kinase (PAK) Family: A Link Between Protein Kinase A and PAK Signaling Pathways?.
S. Faure, S. Vigneron, S. Galas, T. Brassac, C. Delsert, and N. Morin (1999)
J. Biol. Chem. 274, 3573-3579
   Abstract »    Full Text »    PDF »
Dissociation of MAP kinase activation and MPF activation in hormone-stimulated maturation of Xenopus oocytes.
D. Fisher, T Brassac, S Galas, and M Doree (1999)
Development 126, 4537-4546
   Abstract »    PDF »
The beta  subunit of CKII negatively regulates Xenopus oocyte maturation.
M. Chen and J. A. Cooper (1997)
PNAS 94, 9136-9140
   Abstract »    Full Text »    PDF »
Mitogen-activated Protein Kinase and Cyclin B/Cdc2 Phosphorylate Xenopus Nuclear Factor 7 (xnf7) in Extracts from Mature Oocytes. IMPLICATIONS FOR REGULATION OF xnf7 SUBCELLULAR LOCALIZATION.
H. M. El-Hodiri, S. Che, M. Nelman-Gonzalez, J. Kuang, and L. D. Etkin (1997)
J. Biol. Chem. 272, 20463-20470
   Abstract »    Full Text »    PDF »
Analysis of the mechanism(s) of metaphase I arrest in strain LT mouse oocytes: participation of MOS.
Y Hirao and J. Eppig (1997)
Development 124, 5107-5113
   Abstract »    PDF »
Mouse cytoplasmic polyadenylylation element binding protein: An evolutionarily conserved protein that interacts with the cytoplasmic polyadenylylation elements of c-mos mRNA.
F. Gebauer and J. D. Richter (1996)
PNAS 93, 14602-14607
   Abstract »    Full Text »    PDF »
Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse.
M. Verlhac, J. Kubiak, M Weber, G Geraud, W. Colledge, M. Evans, and B Maro (1996)
Development 122, 815-822
   Abstract »    PDF »
Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade.
Y. Gotoh, N. Masuyama, K. Dell, K. Shirakabe, and E. Nishida (1995)
J. Biol. Chem. 270, 25898-25904
   Abstract »    Full Text »    PDF »
Purification and Characterization of REKS from Xenopus Eggs.
S. Kuroda, K. Shimizu, B. Yamamori, S. Matsuda, K. Imazumi, K. Kaibuchi, and Y. Takai (1995)
J. Biol. Chem. 270, 2460-2465
   Abstract »    Full Text »    PDF »
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation..
D Greenstein, S Hird, R H Plasterk, Y Andachi, Y Kohara, B Wang, M Finney, and G Ruvkun (1994)
Genes & Dev. 8, 1935-1948
   Abstract »    PDF »
The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation..
M D Sheets, C A Fox, T Hunt, G Vande Woude, and M Wickens (1994)
Genes & Dev. 8, 926-938
   Abstract »    PDF »
Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase.
O Haccard, B Sarcevic, A Lewellyn, R Hartley, L Roy, T Izumi, E Erikson, and J. Maller (1993)
Science 262, 1262-1265
   Abstract »    PDF »
The ras oncoprotein and M-phase activity.
I Daar, A. Nebreda, N Yew, P Sass, R Paules, E Santos, M Wigler, and G. Vande Woude (1991)
Science 253, 74-76
   Abstract »    PDF »
Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product.
A. Nebreda, D Martin-Zanca, D. Kaplan, L. Parada, and E Santos (1991)
Science 252, 558-561
   Abstract »    PDF »
Ability of the c-mos product to associate with and phosphorylate tubulin.
R. Zhou, M Oskarsson, R. Paules, N Schulz, D Cleveland, and G. Vande Woude (1991)
Science 251, 671-675
   Abstract »    PDF »
Cyclins and Their Partners during Xenopus Oocyte Maturation.
H. Kobayashi, R. Golsteyn, R. Poon, E. Stewart, J. Gannon, J. Minshull, R. Smith, and T. Hunt (1991)
Cold Spring Harb Symp Quant Biol 56, 437-447
   Abstract »    PDF »
Mos and Ras: Two Oncoproteins That Display M-phase Activity.
I. Daar, R. Zhou, R.-L. Shen, A. Nebreda, M. Oskarsson, E. Santos, P. Pinto da Silva, Y. Masui, and G.F. Vande Woude (1991)
Cold Spring Harb Symp Quant Biol 56, 477-488
   Abstract »    PDF »
Concerted Roles of Cyclin A, cdc25+ Mitotic Inducer, and Type 2A Phosphatase in Activating the Cyclin B/cdc2 Protein Kinase at the G2/M Phase Transition.
A. Devault, J.-C. Cavadore, D. Fesquet, J.-C. Labbe, T. Lorca, A. Picard, U. Strausfeld, and M. Doree (1991)
Cold Spring Harb Symp Quant Biol 56, 503-513
   Abstract »    PDF »
Biochemical Identification of Xenopus Pumilio as a Sequence-specific Cyclin B1 mRNA-binding Protein That Physically Interacts with a Nanos Homolog, Xcat-2, and a Cytoplasmic Polyadenylation Element-binding Protein.
S. Nakahata, Y. Katsu, K. Mita, K. Inoue, Y. Nagahama, and M. Yamashita (2001)
J. Biol. Chem. 276, 20945-20953
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)