Related Content
Search Google Scholar for:
|
|
Science 11 August 1989:
Vol. 245. no. 4918, pp. 640 - 643
DOI: 10.1126/science.2562787
|
|
Articles
Science, Vol 245, Issue 4918, 640-643
Copyright © 1989 by American Association for the Advancement of Science
Identification of a zinc finger protein that binds to the sterol regulatory element
TB Rajavashisth,
AK Taylor,
A Andalibi,
KL Svenson,
and
AJ Lusis
Department of Medicine, University of California, Los Angeles 90024.
Cholesterol balance in mammalian cells is maintained in part by sterol-mediated repression of gene transcription for the low density lipoprotein receptor and enzymes in the cholesterol biosynthetic pathway. A promoter sequence termed the sterol regulatory element (SRE) is essential for this repression. With the use of an oligonucleotide containing the SRE to screen a human hepatoma complementary DNA expression library, a clone for a DNA binding protein was isolated that binds to the conserved SRE octanucleotide in both a sequence-specific and a single-strand--specific manner. This protein contains seven highly conserved zinc finger repeats that exhibit striking sequence similarity to retroviral nucleic acid binding proteins (NBPs). We have designated the protein "cellular NBP" (CNBP). CNBP is expressed in a wide variety of tissues, is up regulated by sterols, and exhibits binding specificity that correlates with in vivo function. These properties are consistent with a role in sterol-mediated control of transcription.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Gender difference of androgen actions on skeletal muscle transcriptome.
- M. Yoshioka, A. Boivin, C. Bolduc, and J. St-Amand (2007)
J. Mol. Endocrinol.
39, 119-133
| Abstract »
| Full Text »
| PDF »
- Binding of the Universal Minicircle Sequence Binding Protein at the Kinetoplast DNA Replication Origin.
- I. Onn, I. Kapeller, K. Abu-Elneel, and J. Shlomai (2006)
J. Biol. Chem.
281, 37468-37476
| Abstract »
| Full Text »
| PDF »
- The Recessive Epigenetic swellmap Mutation Affects the Expression of Two Step II Splicing Factors Required for the Transcription of the Cell Proliferation Gene STRUWWELPETER and for the Timing of Cell Cycle Arrest in the Arabidopsis Leaf.
- N. K. Clay and T. Nelson (2005)
PLANT CELL
17, 1994-2008
| Abstract »
| Full Text »
| PDF »
- Redox Potential Regulates Binding of Universal Minicircle Sequence Binding Protein at the Kinetoplast DNA Replication Origin.
- I. Onn, N. Milman-Shtepel, and J. Shlomai (2004)
Eukaryot. Cell
3, 277-287
| Abstract »
| Full Text »
| PDF »
- Quantitative Proteomic Identification of Six4 as the Trex-Binding Factor in the Muscle Creatine Kinase Enhancer.
- C. L. Himeda, J. A. Ranish, J. C. Angello, P. Maire, R. Aebersold, and S. D. Hauschka (2004)
Mol. Cell. Biol.
24, 2132-2143
| Abstract »
| Full Text »
| PDF »
- Human Cellular Nucleic Acid-Binding Protein Zn2+ Fingers Support Replication of Human Immunodeficiency Virus Type 1 When They Are Substituted in the Nucleocapsid Protein.
- C. F. McGrath, J. S. Buckman, T. D. Gagliardi, W. J. Bosche, L. V. Coren, and R. J. Gorelick (2003)
J. Virol.
77, 8524-8531
| Abstract »
| Full Text »
| PDF »
- Gene expression analysis of murine cells producing amphotropic mouse leukaemia virus at a cultivation temperature of 32 and 37 {degrees}C.
- C. Beer, P. Buhr, H. Hahn, D. Laubner, and M. Wirth (2003)
J. Gen. Virol.
84, 1677-1686
| Abstract »
| Full Text »
| PDF »
- The zinc-finger protein CNBP is required for forebrain formation in the mouse.
- W. Chen, Y. Liang, W. Deng, K. Shimizu, A. M. Ashique, E. Li, and Y.-P. Li (2003)
Development
130, 1367-1379
| Abstract »
| Full Text »
| PDF »
- Gene Expression Profiles with Activation of the Estrogen Receptor {alpha}-Selective Estrogen Receptor Modulator Complex in Breast Cancer Cells Expressing Wild-Type Estrogen Receptor.
- A. S. Levenson, K. M. Svoboda, K. M. Pease, S. A. Kaiser, B. Chen, L. A. Simons, B. D. Jovanovic, P. A. Dyck, and V. C. Jordan (2002)
Cancer Res.
62, 4419-4426
| Abstract »
| Full Text »
| PDF »
- Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes.
- M. E. Higgins and Y. A. Ioannou (2001)
J. Lipid Res.
42, 1939-1946
| Abstract »
| Full Text »
| PDF »
- Identification and characterisation of a developmentally regulated mammalian gene that utilises -1 programmed ribosomal frameshifting.
- K. Shigemoto, J. Brennan, E. Walls, C. J. Watson, D. Stott, P. W. J. Rigby, and A. D. Reith (2001)
Nucleic Acids Res.
29, 4079-4088
| Abstract »
| Full Text »
| PDF »
- Myotonic Dystrophy Type 2 Caused by a CCTG Expansion in Intron 1 of ZNF9.
- C. L. Liquori, K. Ricker, M. L. Moseley, J. F. Jacobsen, W. Kress, S. L. Naylor, J. W. Day, and L. P. W. Ranum (2001)
Science
293, 864-867
| Abstract »
| Full Text »
| PDF »
- Mutator-like Elements in Arabidopsis thaliana: Structure, Diversity and Evolution.
- Z. Yu, S. I. Wright, and T. E. Bureau (2000)
Genetics
156, 2019-2031
| Abstract »
| Full Text »
| PDF »
- Oxysterols: Modulators of Cholesterol Metabolism and Other Processes.
- G. J. Schroepfer Jr. (2000)
Physiol Rev
80, 361-554
| Abstract »
| Full Text »
| PDF »
- Segregated Regulatory Elements Direct beta -Myosin Heavy Chain Expression in Response to Altered Muscle Activity.
- J. J. McCarthy, D. R. Vyas, G. L. Tsika, and R. W. Tsika (1999)
J. Biol. Chem.
274, 14270-14279
| Abstract »
| Full Text »
| PDF »
- A Previously Undescribed Intron and Extensive 5' Upstream Sequence, but Not Phox2a-mediated Transactivation, Are Necessary for High Level Cell Type-specific Expression of the Human Norepinephrine Transporter Gene.
- C.-H. Kim, H.-S. Kim, J. F. Cubells, and K.-S. Kim (1999)
J. Biol. Chem.
274, 6507-6518
| Abstract »
| Full Text »
| PDF »
- The p95 Gene of Bombyx mori Nuclear Polyhedrosis Virus: Temporal Expression and Functional Properties.
- M. Lu, L. Swevers, and K. Iatrou (1998)
J. Virol.
72, 4789-4797
| Abstract »
| Full Text »
| PDF »
- Isolation and Characterization of a Novel Member of the Neural Zinc Finger Factor/Myelin Transcription Factor Family with Transcriptional Repression Activity.
- K. S. Y. Yee and V. C. Yu (1998)
J. Biol. Chem.
273, 5366-5374
| Abstract »
| Full Text »
| PDF »
- Single-stranded DNA-binding Proteins and Neuron-restrictive Silencer Factor Participate in Cell-specific Transcriptional Control of the NMDAR1 Gene.
- G. Bai, D. D. Norton, M. S. Prenger, and J. W. Kusiak (1998)
J. Biol. Chem.
273, 1086-1091
| Abstract »
| Full Text »
| PDF »
- Identification and Characterization of Single Strand DNA-Binding Protein That Represses Growth Hormone Receptor Gene Expression.
- R. K. Menon, H. Cheng, and M. Singh (1997)
Mol. Endocrinol.
11, 1291-1304
| Abstract »
| Full Text »
- The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins..
- S M Barabino, W Hubner, A Jenny, L Minvielle-Sebastia, and W Keller (1997)
Genes & Dev.
11, 1703-1716
| Abstract »
| PDF »
- Characterization of a Polypyrimidine/Polypurine Tract in the Promoter of the Gene for Chicken Malic Enzyme.
- G. Xu and A. G. Goodridge (1996)
J. Biol. Chem.
271, 16008-16019
| Abstract »
| Full Text »
| PDF »
- Regulation of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Degradation by the Nonsterol Mevalonate Metabolite Farnesol in Vivo.
- T. E. Meigs, D. S. Roseman, and R. D. Simoni (1996)
J. Biol. Chem.
271, 7916-7922
| Abstract »
| Full Text »
| PDF »
- Universal Minicircle Sequence Binding Protein, a CCHC-type Zinc Finger Protein That Binds the Universal Minicircle Sequence of Trypanosomatids.
- Y. Tzfati, H. Abeliovich, D. Avrahami, and J. Shlomai (1995)
J. Biol. Chem.
270, 21339-21345
| Abstract »
| Full Text »
| PDF »
- Cellular Nucleic Acid Binding Protein Regulates the CT Element of the Human c- myc Protooncogene.
- E. F. Michelotti, T. Tomonaga, H. Krutzsch, and D. Levens (1995)
J. Biol. Chem.
270, 9494-9499
| Abstract »
| Full Text »
| PDF »
- Alternatively Processed Isoforms of Cellular Nucleic Acid-binding Protein Interact with a Suppressor Region of the Human beta-Myosin Heavy Chain Gene.
- I. L. Flink and E. Morkin (1995)
J. Biol. Chem.
270, 6959-6965
| Abstract »
| Full Text »
| PDF »
- DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation.
- D. Hsu, P. Chuang, and B. Meyer (1995)
Development
121, 3323-3334
| Abstract »
| PDF »
- An essential splicing factor, SLU7, mediates 3' splice site choice in yeast..
- D Frank and C Guthrie (1992)
Genes & Dev.
6, 2112-2124
| Abstract »
| PDF »
- Nucleic acid specificity of a vertebrate telomere-binding protein: evidence for G-G base pair recognition at the core-binding site..
- A Gualberto, R M Patrick, and K Walsh (1992)
Genes & Dev.
6, 815-824
| Abstract »
| PDF »
|
|
