Related Content
Search Google Scholar for:
|
|
Science 28 July 1989:
Vol. 245. no. 4916, pp. 417 - 420
DOI: 10.1126/science.2474201
|
|
Articles
Science, Vol 245, Issue 4916, 417-420
Copyright © 1989 by American Association for the Advancement of Science
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
BA Yankner,
LR Dawes,
S Fisher,
L Villa-Komaroff,
ML Oster-Granite,
and
RL Neve
Department of Neurology, Harvard Medical School, Boston, MA.
Amyloid deposition in senile plaques and the cerebral vasculature is a marker of Alzheimer's disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a by-product of that process is unknown. Pheochromocytoma (PC12) and fibroblast (NIH 3T3) cell lines were transfected with portions of the gene for the human amyloid precursor protein. Stable PC12 cell transfectants expressing a specific amyloid-containing fragment of the precursor protein gradually degenerated when induced to differentiate into neuronal cells with nerve growth factor. Conditioned medium from these cells was toxic to neurons in primary hippocampal cultures, and the toxic agent could be removed by immunoabsorption with an antibody directed against the amyloid polypeptide. Thus, a peptide derived from the amyloid precursor may be neurotoxic.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms.
- S. Mulugeta, J. A. Maguire, J. L. Newitt, S. J. Russo, A. Kotorashvili, and M. F. Beers (2007)
Am J Physiol Lung Cell Mol Physiol
293, L720-L729
| Abstract »
| Full Text »
| PDF »
- Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis.
- L. Verret, J. L. Jankowsky, G. M. Xu, D. R. Borchelt, and C. Rampon (2007)
J. Neurosci.
27, 6771-6780
| Abstract »
| Full Text »
| PDF »
- Apoptosis Signal-Regulating Kinase 1 in Amyloid {beta} Peptide-Induced Cerebral Endothelial Cell Apoptosis.
- M.-J. Hsu, C. Y. Hsu, B.-C. Chen, M.-C. Chen, G. Ou, and C.-H. Lin (2007)
J. Neurosci.
27, 5719-5729
| Abstract »
| Full Text »
| PDF »
- Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death..
- K.-J. Yin, C. Y. Hsu, X.-Y. Hu, H. Chen, S.-W. Chen, J. Xu, and J.-M. Lee (2006)
J. Neurosci.
26, 2290-2299
| Abstract »
| Full Text »
| PDF »
- Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.
- K. P. Townsend and D. Pratico (2005)
FASEB J
19, 1592-1601
| Abstract »
| Full Text »
| PDF »
- Amyloid {beta}-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis.
- U. Keil, A. Bonert, C. A. Marques, I. Scherping, J. Weyermann, J. B. Strosznajder, F. Muller-Spahn, C. Haass, C. Czech, L. Pradier, et al. (2004)
J. Biol. Chem.
279, 50310-50320
| Abstract »
| Full Text »
| PDF »
- Caspase-Mediated Degeneration in Alzheimer's Disease.
- D. H. Cribbs, W. W. Poon, R. A. Rissman, and M. Blurton-Jones (2004)
Am. J. Pathol.
165, 353-355
| Full Text »
| PDF »
- Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and A{beta}-induced cell death.
- J. Hitomi, T. Katayama, Y. Eguchi, T. Kudo, M. Taniguchi, Y. Koyama, T. Manabe, S. Yamagishi, Y. Bando, K. Imaizumi, et al. (2004)
J. Cell Biol.
165, 347-356
| Abstract »
| Full Text »
| PDF »
- Oligomerization of Alzheimer's {beta}-Amyloid within Processes and Synapses of Cultured Neurons and Brain.
- R. H. Takahashi, C. G. Almeida, P. F. Kearney, F. Yu, M. T. Lin, T. A. Milner, and G. K. Gouras (2004)
J. Neurosci.
24, 3592-3599
| Abstract »
| Full Text »
| PDF »
- Abnormality of G-Protein-Coupled Receptor Kinases at Prodromal and Early Stages of Alzheimer's Disease: An Association with Early {beta}-Amyloid Accumulation.
- Z. Suo, M. Wu, B. A. Citron, G. T. Wong, and B. W. Festoff (2004)
J. Neurosci.
24, 3444-3452
| Abstract »
| Full Text »
| PDF »
- Intracellular Accumulation of Amyloidogenic Fragments of Amyloid-{beta} Precursor Protein in Neurons with Niemann-Pick Type C Defects Is Associated with Endosomal Abnormalities.
- L.-W. Jin, I. Maezawa, I. Vincent, and T. Bird (2004)
Am. J. Pathol.
164, 975-985
| Abstract »
| Full Text »
| PDF »
- Amyloid-{beta} peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.
- J.-T. Lee, J. Xu, J.-M. Lee, G. Ku, X. Han, D.-I Yang, S. Chen, and C. Y. Hsu (2004)
J. Cell Biol.
164, 123-131
| Abstract »
| Full Text »
| PDF »
- Activation of Muscarinic Receptors Inhibits beta -Amyloid Peptide-induced Signaling in Cortical Slices.
- Z. Gu, P. Zhong, and Z. Yan (2003)
J. Biol. Chem.
278, 17546-17556
| Abstract »
| Full Text »
| PDF »
- Amyloid-beta Induces Smac Release via AP-1/Bim Activation in Cerebral Endothelial Cells.
- K. J. Yin, J.-M. Lee, S. D. Chen, J. Xu, and C. Y. Hsu (2002)
J. Neurosci.
22, 9764-9770
| Abstract »
| Full Text »
| PDF »
- Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.
- Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev.
54, 469-525
| Abstract »
| Full Text »
| PDF »
- Differential Roles of JIP Scaffold Proteins in the Modulation of Amyloid Precursor Protein Metabolism.
- H. Taru, Y. Kirino, and T. Suzuki (2002)
J. Biol. Chem.
277, 27567-27574
| Abstract »
| Full Text »
| PDF »
- Apolipoprotein E4 Potentiates Amyloid beta Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells.
- Z.-S. Ji, R. D. Miranda, Y. M. Newhouse, K. H. Weisgraber, Y. Huang, and R. W. Mahley (2002)
J. Biol. Chem.
277, 21821-21828
| Abstract »
| Full Text »
| PDF »
- Carboxyl-terminal Peptide of beta -Amyloid Precursor Protein Blocks Inositol 1,4,5-Trisphosphate-sensitive Ca2+ Release in Xenopus laevis Oocytes.
- J.-H. Kim, J.-C. Rah, S. P. Fraser, K.-A Chang, M. B. A. Djamgoz, and Y.-H. Suh (2002)
J. Biol. Chem.
277, 20256-20263
| Abstract »
| Full Text »
| PDF »
- Reduced levels of amyloid {beta}-peptide antibody in Alzheimer disease.
- Y. Du, R. Dodel, H. Hampel, K. Buerger, S. Lin, B. Eastwood, K. Bales, F. Gao, H.-J. Moeller, W. Oertel, et al. (2001)
Neurology
57, 801-805
| Abstract »
| Full Text »
| PDF »
- Inflammatory Genes Are Upregulated in Expanded Ataxin-3-Expressing Cell Lines and Spinocerebellar Ataxia Type 3 Brains.
- B. O. Evert, I. R. Vogt, C. Kindermann, L. Ozimek, R. A. I. de Vos, E. R. P. Brunt, I. Schmitt, T. Klockgether, and U. Wullner (2001)
J. Neurosci.
21, 5389-5396
| Abstract »
| Full Text »
| PDF »
- Immunization with a Nontoxic/Nonfibrillar Amyloid-{beta} Homologous Peptide Reduces Alzheimer's Disease-Associated Pathology in Transgenic Mice.
- E. M. Sigurdsson, H. Scholtzova, P. D. Mehta, B. Frangione, and T. Wisniewski (2001)
Am. J. Pathol.
159, 439-447
| Abstract »
| Full Text »
- BACE knockout mice are healthy despite lacking the primary {beta}-secretase activity in brain: implications for Alzheimer's disease therapeutics.
- S. L. Roberds, J. Anderson, G. Basi, M. J. Bienkowski, D. G. Branstetter, K. S. Chen, S. Freedman, N. L. Frigon, D. Games, K. Hu, et al. (2001)
Hum. Mol. Genet.
10, 1317-1324
| Abstract »
| Full Text »
| PDF »
- Selective and Protracted Apoptosis in Human Primary Neurons Microinjected with Active Caspase-3, -6, -7, and -8.
- Y. Zhang, C. Goodyer, and A. LeBlanc (2000)
J. Neurosci.
20, 8384-8389
| Abstract »
| Full Text »
| PDF »
- Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.
- S. A. FARBER, B. E. SLACK, and J. K. BLUSZTAJN (2000)
FASEB J
14, 2198-2206
| Abstract »
| Full Text »
- Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.
- H.-S. KIM, C. H. PARK, S. H. CHA, J.-H. LEE, S. LEE, Y. KIM, J.-C. RAH, S.-J. JEONG, and Y.-H. SUH (2000)
FASEB J
14, 1508-1517
| Abstract »
| Full Text »
- High-Level Neuronal Expression of Abeta 1-42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation.
- L. Mucke, E. Masliah, G.-Q. Yu, M. Mallory, E. M. Rockenstein, G. Tatsuno, K. Hu, D. Kholodenko, K. Johnson-Wood, and L. McConlogue (2000)
J. Neurosci.
20, 4050-4058
| Abstract »
| Full Text »
| PDF »
- A ßPP Peptide Carboxyl-Terminal to Aß Is Neurotoxic.
- G. Marcon, G. Giaccone, B. Canciani, L. Cajola, G. Rossi, L. De Gioia, M. Salmona, O. Bugiani, and F. Tagliavini (1999)
Am. J. Pathol.
154, 1001-1007
| Abstract »
| Full Text »
| PDF »
- Binding and Selective Detection of the Secretory N-terminal Domain of the Alzheimer Amyloid Precursor Protein on Cell Surfaces.
- J. Hoffmann, C. U. Pietrzik, M. P. Kummer, C. Twiesselmann, C. Bauer, and V. Herzog (1999)
J. Histochem. Cytochem.
47, 373-382
| Abstract »
| Full Text »
- Transgenic Mice Over-Expressing the C-99 Fragment of ßPP with an {alpha}-Secretase Site Mutation Develop a Myopathy Similar to Human Inclusion Body Myositis.
- L.-W. Jin, M. G. Hearn, C. E. Ogburn, N. Dang, D. Nochlin, W. C. Ladiges, and G. M. Martin (1998)
Am. J. Pathol.
153, 1679-1686
| Abstract »
| Full Text »
| PDF »
- A Novel, Synergistic Interaction Between 17 beta -Estradiol and Glutathione in the Protection of Neurons against beta -Amyloid 25-35-Induced Toxicity In Vitro.
- K. E. Gridley, P. S. Green, and J. W. Simpkins (1998)
Mol. Pharmacol.
54, 874-880
| Abstract »
| Full Text »
- The Neuronal Growth-Associated Protein GAP-43 Interacts with Rabaptin-5 and Participates in Endocytosis.
- R. L. Neve, R. Coopersmith, D. L. McPhie, C. Santeufemio, K. G. Pratt, C. J. Murphy, and S. D. Lynn (1998)
J. Neurosci.
18, 7757-7767
| Abstract »
| Full Text »
| PDF »
- Survival of Cultured Neurons from Amyloid Precursor Protein Knock-Out Mice against Alzheimer's Amyloid-beta Toxicity and Oxidative Stress.
- A. R. White, H. Zheng, D. Galatis, F. Maher, L. Hesse, G. Multhaup, K. Beyreuther, C. L. Masters, and R. Cappai (1998)
J. Neurosci.
18, 6207-6217
| Abstract »
| Full Text »
| PDF »
- Stable Complexes Involving Acetylcholinesterase and Amyloid-beta Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer's Fibrils.
- A. Alvarez, R. Alarcon, C. Opazo, E. O. Campos, F. J. Munoz, F. H. Calderon, F. Dajas, M. K. Gentry, B. P. Doctor, F. G. De Mello, et al. (1998)
J. Neurosci.
18, 3213-3223
| Abstract »
| Full Text »
| PDF »
- Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Abeta Production in Human Primary Neuron Cultures..
- A. C. LeBlanc, M. Koutroumanis, and C. G. Goodyer (1998)
J. Neurosci.
18, 2907-2913
| Abstract »
| Full Text »
| PDF »
- Neuronal Expression of beta -Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid beta and Cytoplasmic Domains.
- D. L. McPhie, R. K. K. Lee, C. B. Eckman, D. H. Olstein, S. P. Durham, D. Yager, S. G. Younkin, R. J. Wurtman, and R. L. Neve (1997)
J. Biol. Chem.
272, 24743-24746
| Abstract »
| Full Text »
| PDF »
- Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta -amyloid precursor protein by different protease activities.
- M. Citron, T. S. Diehl, G. Gordon, A. L. Biere, P. Seubert, and D. J. Selkoe (1996)
PNAS
93, 13170-13175
| Abstract »
| Full Text »
| PDF »
- Age-Dependent Neuronal and Synaptic Degeneration in Mice Transgenic for the C Terminus of the Amyloid Precursor Protein.
- M. L. Oster-Granite, D. L. McPhie, J. Greenan, and R. L. Neve (1996)
J. Neurosci.
16, 6732-6741
| Abstract »
| Full Text »
| PDF »
- Low Blood Pressure in Down's Syndrome: A Link With Alzheimer's Disease?.
- R. A. Morrison, A. McGrath, G. Davidson, J. J. Brown, G. D. Murray, and A. F. Lever (1996)
Hypertension
28, 569-575
| Abstract »
| Full Text »
- Intracellular A[IMAGE]1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells.
- A. J. Yang, M. Knauer, D. A. Burdick, and C. Glabe (1995)
J. Biol. Chem.
270, 14786-14792
| Abstract »
| Full Text »
| PDF »
- The treatment of Alzheimer's disease.
- N.H.P. Allen and A. Burns (1995)
J Psychopharmacol
9, 43-56
| PDF »
- Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels.
- R Etcheberrigaray, E Ito, C. Kim, and D. Alkon (1994)
Science
264, 276-279
| Abstract »
| PDF »
- Alzheimer's disease: the amyloid cascade hypothesis.
- J. Hardy and G. Higgins (1992)
Science
256, 184-185
| PDF »
- Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.
- S Estus, T. Golde, T Kunishita, D Blades, D Lowery, M Eisen, M Usiak, X. Qu, T Tabira, B. Greenberg, et al. (1992)
Science
255, 726-728
| Abstract »
| PDF »
- Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
- B. Yankner, L. Duffy, and D. Kirschner (1990)
Science
250, 279-282
| Abstract »
| PDF »
- A Novel gamma -Secretase Assay Based on Detection of the Putative C-terminal Fragment-gamma of Amyloid beta Protein Precursor.
- I. Pinnix, U. Musunuru, H. Tun, A. Sridharan, T. Golde, C. Eckman, C. Ziani-Cherif, L. Onstead, and K. Sambamurti (2001)
J. Biol. Chem.
276, 481-487
| Abstract »
| Full Text »
| PDF »
- Effects of the beta -Amyloid and Carboxyl-terminal Fragment of Alzheimer's Amyloid Precursor Protein on the Production of the Tumor Necrosis Factor-alpha and Matrix Metalloproteinase-9 by Human Monocytic THP-1.
- Y. H. Chong, J. H. Sung, S. A. Shin, J.-H. Chung, and Y.-H. Suh (2001)
J. Biol. Chem.
276, 23511-23517
| Abstract »
| Full Text »
| PDF »
- Amyloid-{beta} Peptides Are Cytotoxic to Oligodendrocytes.
- J. Xu, S. Chen, S. H. Ahmed, H. Chen, G. Ku, M. P. Goldberg, and C. Y. Hsu (2001)
J. Neurosci.
21, RC118
| Abstract »
| Full Text »
| PDF »
|
|
