Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 28 July 1989:
Vol. 245. no. 4916, pp. 371 - 378
DOI: 10.1126/science.2667136

Articles

Science, Vol 245, Issue 4916, 371-378
Copyright © 1989 by American Association for the Advancement of Science


articles

Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins

PJ Mitchell and R Tjian

Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley 94720.

The cloning of genes encoding mammalian DNA binding transcription factors for RNA polymerase II has provided the opportunity to analyze the structure and function of these proteins. This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors. The mechanisms by which these factors may activate transcriptional initiation and by which they may be regulated to achieve differential gene expression are also discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transcriptional Regulation of the Salivary Histatin Gene: Finding of a Strong Positive Regulatory Element and Its Binding Protein.
Y. Imamura, Y. Fujigaki, Y. Oomori, K. Ouryouji, S. Yanagisawa, H. Miyazawa, and P.-L. Wang (2009)
J. Biochem. 145, 279-288
   Abstract »    Full Text »    PDF »
Intron Loss Is Associated with Gain of Function in the Evolution of the Gloverin Family of Antibacterial Genes in Bombyx mori.
N. Mrinal and J. Nagaraju (2008)
J. Biol. Chem. 283, 23376-23387
   Abstract »    Full Text »    PDF »
Proximal-distal patterns of transcription factor gene expression during Arabidopsis root development.
P. Derbyshire, S. Drea, P. J. Shaw, J. H. Doonan, and L. Dolan (2008)
J. Exp. Bot.
   Abstract »    Full Text »    PDF »
Transactivation of lung lysozyme expression by Ets family member ESE-1.
W. Lei, R. J. Jaramillo, and K. S. Harrod (2007)
Am J Physiol Lung Cell Mol Physiol 293, L1359-L1368
   Abstract »    Full Text »    PDF »
Basic Helix-Loop-Helix Transcription Factor Heterocomplex of Yas1p and Yas2p Regulates Cytochrome P450 Expression in Response to Alkanes in the Yeast Yarrowia lipolytica.
S. Endoh-Yamagami, K. Hirakawa, D. Morioka, R. Fukuda, and A. Ohta (2007)
Eukaryot. Cell 6, 734-743
   Abstract »    Full Text »    PDF »
Transcriptional Activation Domains of the Candida albicans Gcn4p and Gal4p Homologs.
M. Martchenko, A. Levitin, and M. Whiteway (2007)
Eukaryot. Cell 6, 291-301
   Abstract »    Full Text »    PDF »
Morphological Change Caused by Loss of the Taxon-Specific Polyalanine Tract in Hoxd-13.
K. Anan, N. Yoshida, Y. Kataoka, M. Sato, H. Ichise, M. Nasu, and S. Ueda (2007)
Mol. Biol. Evol. 24, 281-287
   Abstract »    Full Text »    PDF »
Selection and Slippage Creating Serine Homopolymers.
M. A. Huntley and G. B. Golding (2006)
Mol. Biol. Evol. 23, 2017-2025
   Abstract »    Full Text »    PDF »
Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7.
S. Smaldone and F. Ramirez (2006)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.
L. M. Mikhaylova, A. M. Boutanaev, and D. I. Nurminsky (2006)
PNAS 103, 11975-11980
   Abstract »    Full Text »    PDF »
Cytoplasmic IRE1{alpha}-mediated XBP1 mRNA Splicing in the Absence of Nuclear Processing and Endoplasmic Reticulum Stress.
S. H. Back, K. Lee, E. Vink, and R. J. Kaufman (2006)
J. Biol. Chem. 281, 18691-18706
   Abstract »    Full Text »    PDF »
Transcriptional activators in yeast.
B. Titz, S. Thomas, S. V. Rajagopala, T. Chiba, T. Ito, and P. Uetz (2006)
Nucleic Acids Res. 34, 955-967
   Abstract »    Full Text »    PDF »
The Forkhead Transcription Factor FoxI1 Remains Bound to Condensed Mitotic Chromosomes and Stably Remodels Chromatin Structure.
J. Yan, L. Xu, G. Crawford, Z. Wang, and S. M. Burgess (2006)
Mol. Cell. Biol. 26, 155-168
   Abstract »    Full Text »    PDF »
A highly distinctive mechanical property found in the majority of human promoters and its transcriptional relevance.
Y. Fukue, N. Sumida, J.-i. Tanase, and T. Ohyama (2005)
Nucleic Acids Res. 33, 3821-3827
   Abstract »    Full Text »    PDF »
Identification of functional domains within the bICP0 protein encoded by bovine herpesvirus 1.
Y. Zhang, J. Zhou, and C. Jones (2005)
J. Gen. Virol. 86, 879-886
   Abstract »    Full Text »    PDF »
Expression-based monitoring of transcription factor activity: the TELiS database.
S. W. Cole, W. Yan, Z. Galic, J. Arevalo, and J. A. Zack (2005)
Bioinformatics 21, 803-810
   Abstract »    Full Text »    PDF »
Positive and Negative Regulation of Nuclear Factor-{kappa}B-mediated Transcription by I{kappa}B-{zeta}, an Inducible Nuclear Protein.
M. Motoyama, S. Yamazaki, A. Eto-Kimura, K. Takeshige, and T. Muta (2005)
J. Biol. Chem. 280, 7444-7451
   Abstract »    Full Text »    PDF »
Common Effects of Acidic Activators on Large-Scale Chromatin Structure and Transcription.
A. E. Carpenter, S. Memedula, M. J. Plutz, and A. S. Belmont (2005)
Mol. Cell. Biol. 25, 958-968
   Abstract »    Full Text »    PDF »
BLR-1 and BLR-2, key regulatory elements of photoconidiation and mycelial growth in Trichoderma atroviride.
S. Casas-Flores, M. Rios-Momberg, M. Bibbins, P. Ponce-Noyola, and A. Herrera-Estrella (2004)
Microbiology 150, 3561-3569
   Abstract »    Full Text »    PDF »
Adenovirus-Mediated Transfer of Thyroid Transcription Factor-1 Induces Radioiodide Organification and Retention in Thyroid Cancer Cells.
F. Furuya, H. Shimura, A. Miyazaki, K. Taki, K. Ohta, K. Haraguchi, T. Onaya, T. Endo, and T. Kobayashi (2004)
Endocrinology 145, 5397-5405
   Abstract »    Full Text »    PDF »
The role of SEUSS in auxin response and floral organ patterning.
J. Pfluger and P. Zambryski (2004)
Development 131, 4697-4707
   Abstract »    Full Text »    PDF »
The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene.
D. Braas, H. Gundelach, and K.-H. Klempnauer (2004)
Nucleic Acids Res. 32, 4750-4757
   Abstract »    Full Text »    PDF »
Mapping activation and repression domains of the vnd/NK-2 homeodomain protein.
A. Stepchenko and M. Nirenberg (2004)
PNAS 101, 13180-13185
   Abstract »    Full Text »    PDF »
Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions.
Y. Suzuki, R. Yamashita, M. Shirota, Y. Sakakibara, J. Chiba, J. Mizushima-Sugano, K. Nakai, and S. Sugano (2004)
Genome Res. 14, 1711-1718
   Abstract »    Full Text »    PDF »
Kruppel-like Factor 15, a Zinc-Finger Transcriptional Regulator, Represses the Rhodopsin and Interphotoreceptor Retinoid-Binding Protein Promoters.
D. C. Otteson, Y. Liu, H. Lai, C. Wang, S. Gray, M. K. Jain, and D. J. Zack (2004)
Invest. Ophthalmol. Vis. Sci. 45, 2522-2530
   Abstract »    Full Text »    PDF »
Whole Genome Analysis of the OsGRF Gene Family Encoding Plant-Specific Putative Transcription Activators in Rice (Oryza sativa L.).
D. Choi, J. H. Kim, and H. Kende (2004)
Plant Cell Physiol. 45, 897-904
   Abstract »    Full Text »    PDF »
Transgenic pigs expressing plant genes.
H. Niemann (2004)
PNAS 101, 7211-7212
   Full Text »    PDF »
Rosbin: A Novel Homeobox-Like Protein Gene Expressed Exclusively in Round Spermatids.
T. Takahashi, H. Tanaka, N. Iguchi, K. Kitamura, Y. Chen, M. Maekawa, H. Nishimura, H. Ohta, Y. Miyagawa, K. Matsumiya, et al. (2004)
Biol Reprod 70, 1485-1492
   Abstract »    Full Text »    PDF »
Identification, Mutational Analysis, and Coactivator Requirements of Two Distinct Transcriptional Activation Domains of the Saccharomyces cerevisiae Hap4 Protein.
J. L. Stebbins and S. J. Triezenberg (2004)
Eukaryot. Cell 3, 339-347
   Abstract »    Full Text »    PDF »
Comparative Analysis of Amino Acid Repeats in Rodents and Humans.
M. M. Alba and R. Guigo (2004)
Genome Res. 14, 549-554
   Abstract »    Full Text »    PDF »
Neurological Proteins Are Not Enriched For Repetitive Sequences.
M. A. Huntley and G. B. Golding (2004)
Genetics 166, 1141-1154
   Abstract »    Full Text »    PDF »
Identification of MoKA, a Novel F-Box Protein That Modulates Kruppel-Like Transcription Factor 7 Activity.
S. Smaldone, F. Laub, C. Else, C. Dragomir, and F. Ramirez (2004)
Mol. Cell. Biol. 24, 1058-1069
   Abstract »    Full Text »    PDF »
Molecular cloning and characterization of Mustang, a novel nuclear protein expressed during skeletal development and regeneration.
F. LOMBARDO, D. KOMATSU, and M. HADJIARGYROU (2004)
FASEB J 18, 52-61
   Abstract »    Full Text »    PDF »
Germline Cell Death Is Inhibited by P-Element Insertions Disrupting the dcp-1/pita Nested Gene Pair in Drosophila.
B. Laundrie, J. S. Peterson, J. S. Baum, J. C. Chang, D. Fileppo, S. R. Thompson, and K. McCall (2003)
Genetics 165, 1881-1888
   Abstract »    Full Text »    PDF »
Mutation in the ap2-6 allele causes recognition of a cryptic splice site.
M. P. Wakem and S. E. Kohalmi (2003)
J. Exp. Bot. 54, 2655-2660
   Abstract »    Full Text »    PDF »
Multiple Domains of TonEBP Cooperate to Stimulate Transcription in Response to Hypertonicity.
S. D. Lee, E. Colla, M. R. Sheen, K. Y. Na, and H. M. Kwon (2003)
J. Biol. Chem. 278, 47571-47577
   Abstract »    Full Text »    PDF »
Cha, a Basic Helix-Loop-Helix Transcription Factor Involved in the Regulation of Upstream Stimulatory Factor Activity.
C. I. Rodriguez, N. Girones, and M. Fresno (2003)
J. Biol. Chem. 278, 43135-43145
   Abstract »    Full Text »    PDF »
Functional Analysis of RF2a, a Rice Transcription Factor.
S. Dai, S. Petruccelli, M. I. Ordiz, Z. Zhang, S. Chen, and R. N. Beachy (2003)
J. Biol. Chem. 278, 36396-36402
   Abstract »    Full Text »    PDF »
PromoSer: a large-scale mammalian promoter and transcription start site identification service.
A. S. Halees, D. Leyfer, and Z. Weng (2003)
Nucleic Acids Res. 31, 3554-3559
   Abstract »    Full Text »    PDF »
Molecular and Biochemical Characterization of VR-EILs Encoding Mung Bean ETHYLENE INSENSITIVE3-LIKE Proteins.
J.-H. Lee and W. T. Kim (2003)
Plant Physiology 132, 1475-1488
   Abstract »    Full Text »    PDF »
High-level activation by a duodenum-specific enhancer requires functional GATA binding sites.
M. R. Dusing, E. A. Florence, and D. A. Wiginton (2003)
Am J Physiol Gastrointest Liver Physiol 284, G1053-G1065
   Abstract »    Full Text »    PDF »
Critical Enhancer Region to Which AhR/ARNT and Sp1 Bind in the Human CYP1B1 Gene.
Y. Tsuchiya, M. Nakajima, and T. Yokoi (2003)
J. Biochem. 133, 583-592
   Abstract »    Full Text »    PDF »
Increased Sp1-dependent Transactivation of the LAMgamma 1 Promoter in Hepatic Stellate Cells Co-cultured with HepG2 Cells Overexpressing Cytochrome P450 2E1.
N. Nieto and A. I. Cederbaum (2003)
J. Biol. Chem. 278, 15360-15372
   Abstract »    Full Text »    PDF »
A Nucleoprotein Complex Containing Sp1, C/EBP{beta}, and HMGI-Y Controls Human Insulin Receptor Gene Transcription.
D. Foti, R. Iuliano, E. Chiefari, and A. Brunetti (2003)
Mol. Cell. Biol. 23, 2720-2732
   Abstract »    Full Text »    PDF »
Drosophila DSP1 and Rat HMGB1 Have Equivalent DNA Binding Properties and Share a Similar Secondary Fold.
C. Janke, D. Martin, M.-J. Giraud-Panis, M. Decoville, and D. Locker (2003)
J. Biochem. 133, 533-539
   Abstract »    Full Text »    PDF »
Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs.
B. He and E. M. Wilson (2003)
Mol. Cell. Biol. 23, 2135-2150
   Abstract »    Full Text »    PDF »
cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein.
J. D. Ferraris, P. Persaud, C. K. Williams, Y. Chen, and M. B. Burg (2002)
PNAS 99, 16800-16805
   Abstract »    Full Text »    PDF »
Functional Interaction of Nuclear Factor Y and Sp1 Is Required for Activation of the Epstein-Barr Virus C Promoter.
C. Borestrom, H. Zetterberg, K. Liff, and L. Rymo (2002)
J. Virol. 77, 821-829
   Abstract »    Full Text »    PDF »
Transcription Initiation Activity of Adenovirus Left-End Sequence in Adenovirus Vectors with E1 Deleted.
M. Yamamoto, J. Davydova, K. Takayama, R. Alemany, and D. T. Curiel (2002)
J. Virol. 77, 1633-1637
   Abstract »    Full Text »    PDF »
Detection and Visualization of Compositionally Similar cis-Regulatory Element Clusters in Orthologous and Coordinately Controlled Genes.
A. G. Jegga, S. P. Sherwood, J. W. Carman, A. T. Pinski, J. L. Phillips, J. P. Pestian, and B. J. Aronow (2002)
Genome Res. 12, 1408-1417
   Abstract »    Full Text »    PDF »
Functional Domains and DNA-binding Sequences of RFLAT-1/KLF13, a Kruppel-like Transcription Factor of Activated T Lymphocytes.
A. Song, A. Patel, K. Thamatrakoln, C. Liu, D. Feng, C. Clayberger, and A. M. Krensky (2002)
J. Biol. Chem. 277, 30055-30065
   Abstract »    Full Text »    PDF »
Essential Role of the 58-kDa Microspherule Protein in the Modulation of Daxx-dependent Transcriptional Repression as Revealed by Nucleolar Sequestration.
D.-Y. Lin and H.-M. Shih (2002)
J. Biol. Chem. 277, 25446-25456
   Abstract »    Full Text »    PDF »
Characterization of the Human Gene Encoding the Scavenger Receptor Expressed by Endothelial Cell and Its Regulation by a Novel Transcription Factor, Endothelial Zinc Finger Protein-2.
H. Adachi and M. Tsujimoto (2002)
J. Biol. Chem. 277, 24014-24021
   Abstract »    Full Text »    PDF »
Targeted Disruption of the GAS41 Gene Encoding a Putative Transcription Factor Indicates That GAS41 Is Essential for Cell Viability.
K. Zimmermann, K. Ahrens, S. Matthes, J.-M. Buerstedde, W. H. Stratling, and L. Phi-van (2002)
J. Biol. Chem. 277, 18626-18631
   Abstract »    Full Text »    PDF »
Differential Role of the Proline-rich Domain of Nuclear Factor 1-C Splice Variants in DNA Binding and Transactivation.
F. Prado, G. Vicent, C. Cardalda, and M. Beato (2002)
J. Biol. Chem. 277, 16383-16390
   Abstract »    Full Text »    PDF »
bcn-1 Element-dependent Activation of the Laminin gamma 1 Chain Gene by the Cooperative Action of Transcription Factor E3 (TFE3) and Smad Proteins.
Y. Kawata, H. Suzuki, Y. Higaki, O. Denisenko, D. Schullery, C. Abrass, and K. Bomsztyk (2002)
J. Biol. Chem. 277, 11375-11384
   Abstract »    Full Text »    PDF »
The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.
Y. Guo, R. Costa, H. Ramsey, T. Starnes, G. Vance, K. Robertson, M. Kelley, R. Reinbold, H. Scholer, and R. Hromas (2002)
PNAS 99, 3663-3667
   Abstract »    Full Text »    PDF »
Phenotypic Complementation Establishes Requirements for Specific POU Domain and Generic Transactivation Function of Oct-3/4 in Embryonic Stem Cells.
H. Niwa, S. Masui, I. Chambers, A. G. Smith, and J.-i. Miyazaki (2002)
Mol. Cell. Biol. 22, 1526-1536
   Abstract »    Full Text »    PDF »
AtREM1, a Member of a New Family of B3 Domain-Containing Genes, Is Preferentially Expressed in Reproductive Meristems.
J. M. Franco-Zorrilla, P. Cubas, J. A. Jarillo, B. Fernandez-Calvin, J. Salinas, and J. M. Martinez-Zapater (2002)
Plant Physiology 128, 418-427
   Abstract »    Full Text »    PDF »
The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea.
Y. Sedaghat, W. F. Miranda, and M. J. Sonnenfeld (2002)
Development 129, 2591-2606
   Abstract »    Full Text »    PDF »
A Common Single Nucleotide Polymorphism in the CD14 Promoter Decreases the Affinity of Sp Protein Binding and Enhances Transcriptional Activity.
T. D. LeVan, J. W. Bloom, T. J. Bailey, C. L. Karp, M. Halonen, F. D. Martinez, and D. Vercelli (2001)
J. Immunol. 167, 5838-5844
   Abstract »    Full Text »    PDF »
cDNA Cloning and Characterization of a High Affinity Aryl Hydrocarbon Receptor in a Cetacean, the Beluga, Delphinapterus leucas.
B. A. Jensen and M. E. Hahn (2001)
Toxicol. Sci. 64, 41-56
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Gonadotropin-Inducible Ovarian Transcription Factors (GIOT1 and -2) That Are Novel Members of the (Cys)2-(His)2-Type Zinc Finger Protein Family.
T. Mizutani, K. Yamada, T. Yazawa, T. Okada, T. Minegishi, and K. Miyamoto (2001)
Mol. Endocrinol. 15, 1693-1705
   Abstract »    Full Text »    PDF »
Expression of the Three Human Major Histocompatibility Complex Class II Isotypes Exhibits a Differential Dependence on the Transcription Factor RFXAP.
M. Peretti, J. Villard, E. Barras, M. Zufferey, and W. Reith (2001)
Mol. Cell. Biol. 21, 5699-5709
   Abstract »    Full Text »    PDF »
A Conserved {alpha}-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A.
J.-S. Zhang, M. C. Moncrieffe, J. Kaczynski, V. Ellenrieder, F. G. Prendergast, and R. Urrutia (2001)
Mol. Cell. Biol. 21, 5041-5049
   Abstract »    Full Text »    PDF »
The Transcriptional Activation Domain of the Plant-Specific Dof1 Factor Functions in Plant, Animal, and Yeast Cells.
S. Yanagisawa (2001)
Plant Cell Physiol. 42, 813-822
   Abstract »    Full Text »    PDF »
Promoter-Proximal Regulatory Elements Involved in oriP-EBNA1-Independent and -Dependent Activation of the Epstein-Barr Virus C Promoter in B-Lymphoid Cell Lines.
T. Nilsson, H. Zetterberg, Y. C. Wang, and L. Rymo (2001)
J. Virol. 75, 5796-5811
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Vitamin D3 Receptor Gene by ZEB.
D. L. Lazarova, M. Bordonaro, and A. C. Sartorelli (2001)
Cell Growth Differ. 12, 319-326
   Abstract »    Full Text »    PDF »
Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y).
A. BRUNETTI, G. MANFIOLETTI, E. CHIEFARI, I. D. GOLDFINE, and D. FOTI (2001)
FASEB J 15, 492-500
   Abstract »    Full Text »    PDF »
The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes.
M. Ruhf, A Braun, O Papoulas, J. Tamkun, N Randsholt, and M Meister (2001)
Development 128, 1429-1441
   Abstract »    PDF »
DNA binding and transcription activation by chicken interferon regulatory factor-3 (chIRF-3).
C. E. Grant, D. L. May, and R. G. Deeley (2000)
Nucleic Acids Res. 28, 4790-4799
   Abstract »    Full Text »    PDF »
Orchestrated response: a symphony of transcription factors for gene control.
B. Lemon and R. Tjian (2000)
Genes & Dev. 14, 2551-2569
   Full Text »
Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression.
J. A. Harton and J. P.-Y. Ting (2000)
Mol. Cell. Biol. 20, 6185-6194
   Full Text »
Neuron-Specific Expression of the Rat Gonadotropin-Releasing Hormone Gene Is Conferred by Interactions of a Defined Promoter Element with the Enhancer in GT1-7 Cells.
S. B. Nelson, M. A. Lawson, C. G. Kelley, and P. L. Mellon (2000)
Mol. Endocrinol. 14, 1509-1522
   Abstract »    Full Text »
Molecular Control of Expression of Penicillin Biosynthesis Genes in Fungi: Regulatory Proteins Interact with a Bidirectional Promoter Region.
J. F. Martín (2000)
J. Bacteriol. 182, 2355-2362
   Full Text »
Evi9 Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene Product.
T. Nakamura, Y. Yamazaki, Y. Saiki, M. Moriyama, D. A. Largaespada, N. A. Jenkins, and N. G. Copeland (2000)
Mol. Cell. Biol. 20, 3178-3186
   Abstract »    Full Text »
Inducible expression of basic transcription element-binding protein 2 in proliferating smooth muscle cells at the vascular anastomotic stricture.
T. Ogata, M. Kurabayashi, Y.-i. Hoshino, K.-i. Sekiguchi, S. Ishikawa, Y. Morishita, and R. Nagai (2000)
J. Thorac. Cardiovasc. Surg. 119, 983-989
   Abstract »    Full Text »    PDF »
Molecular Cloning and Expression Analysis of the Complementary Deoxyribonucleic Acid for Chicken Inhibin/Activin {beta}B Subunit.
D. J. Hecht, A. J. Davis, C. F. Brooks, and P. A. Johnson (2000)
Biol Reprod 62, 1128-1134
   Abstract »    Full Text »
Characterization and Regulation of the 5'-Flanking Region of the Murine Endothelial Protein C Receptor Gene.
J.-M. Gu, K. Fukudome, and C. T. Esmon (2000)
J. Biol. Chem. 275, 12481-12488
   Abstract »    Full Text »    PDF »
Conservation of Glutamine-Rich Transactivation Function between Yeast and Humans.
D. Escher, M. Bodmer-Glavas, A. Barberis, and W. Schaffner (2000)
Mol. Cell. Biol. 20, 2774-2782
   Abstract »    Full Text »
Identification and Functional Characterization of a Conserved, Nuclear Factor 1-like Element in the Proximal Promoter Region of CYP1A2 Gene Specifically Expressed in the Liver and Olfactory Mucosa.
J. Zhang, Q.-Y. Zhang, J. Guo, Y. Zhou, and X. Ding (2000)
J. Biol. Chem. 275, 8895-8902
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Human CYP1B1 Gene. EVIDENCE FOR INVOLVEMENT OF AN ARYL HYDROCARBON RECEPTOR RESPONSE ELEMENT IN CONSTITUTIVE EXPRESSION.
S. E. Shehin, R. O. Stephenson, and W. F. Greenlee (2000)
J. Biol. Chem. 275, 6770-6776
   Abstract »    Full Text »    PDF »
Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction.
D. E. Geiman, H. Ton-That, J. M. Johnson, and V. W. Yang (2000)
Nucleic Acids Res. 28, 1106-1113
   Abstract »    Full Text »    PDF »
A Novel Gibberellin-Induced Gene from Rice and Its Potential Regulatory Role in Stem Growth.
E. van der Knaap, J. H. Kim, and H. Kende (2000)
Plant Physiology 122, 695-704
   Abstract »    Full Text »    PDF »
Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues.
L Molin, A Mounsey, S Aslam, P Bauer, J Young, M James, A Sharma-Oates, and I. Hope (2000)
Development 127, 4825-4835
   Abstract »    PDF »
Molecular Cloning of a Zinc Finger Autoantigen Transiently Associated with Interphase Nucleolus and Mitotic Centromeres and Midbodies. ORTHOLOGOUS PROTEINS WITH NINE CXXC MOTIFS HIGHLY CONSERVED FROM NEMATODES TO HUMANS.
J. Bolivar, I. Diaz, C. Iglesias, and M. M. Valdivia (1999)
J. Biol. Chem. 274, 36456-36464
   Abstract »    Full Text »    PDF »
The Activation Domain of Herpesvirus Saimiri R Protein Interacts with the TATA-Binding Protein.
K. T. Hall, A. J. Stevenson, D. J. Goodwin, P. C. Gibson, A. F. Markham, and A. Whitehouse (1999)
J. Virol. 73, 9756-9763
   Abstract »    Full Text »
CTp11, a Novel Member of the Family of Human Cancer/Testis Antigens.
A. J. W. Zendman, I. M. H. A. Cornelissen, U. H. Weidle, D. J. Ruiter, and G. N. P. van Muijen (1999)
Cancer Res. 59, 6223-6229
   Abstract »    Full Text »    PDF »
Effects of methionine on endogenous antioxidants in the heart.
C. K. Seneviratne, T. Li, N. Khaper, and P. K. Singal (1999)
Am J Physiol Heart Circ Physiol 277, H2124-H2128
   Abstract »    Full Text »    PDF »
The Role of Human MBF1 as a Transcriptional Coactivator.
Y. Kabe, M. Goto, D. Shima, T. Imai, T. Wada, K.-i. Morohashi, M. Shirakawa, S. Hirose, and H. Handa (1999)
J. Biol. Chem. 274, 34196-34202
   Abstract »    Full Text »    PDF »
Stimulation of DNA Replication in Saccharomyces cerevisiae by a Glutamine- and Proline-rich Transcriptional Activation Domain.
R. Li (1999)
J. Biol. Chem. 274, 30310-30314
   Abstract »    Full Text »    PDF »
Three Conserved Transcriptional Repressor Domains Are a Defining Feature of the TIEG Subfamily of Sp1-like Zinc Finger Proteins.
T. Cook, B. Gebelein, M. Belal, K. Mesa, and R. Urrutia (1999)
J. Biol. Chem. 274, 29500-29504
   Abstract »    Full Text »    PDF »
The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.
P. Rollini and R. E. K. Fournier (1999)
PNAS 96, 10308-10313
   Abstract »    Full Text »    PDF »
Phospholipase C-gamma 1 Is Required for Calcium-induced Keratinocyte Differentiation.
Z. Xie and D. D. Bikle (1999)
J. Biol. Chem. 274, 20421-20424
   Abstract »    Full Text »    PDF »
Mpl Ligand Enhances the Transcription of the Cyclin D3 Gene: A Potential Role for Sp1 Transcription Factor.
Z. Wang, Y. Zhang, J. Lu, S. Sun, and K. Ravid (1999)
Blood 93, 4208-4221
   Abstract »    Full Text »    PDF »
Two Novel Kruppel-associated Box-containing Zinc-finger Proteins, KRAZ1 and KRAZ2, Repress Transcription through Functional Interaction with the Corepressor KAP-1 (TIF1beta /KRIP-1).
Y. Agata, E. Matsuda, and A. Shimizu (1999)
J. Biol. Chem. 274, 16412-16422
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)