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Science 28 July 1989: Vol. 245. no. 4916, pp. 371 - 378 DOI: 10.1126/science.2667136
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Articles
Science, Vol 245, Issue 4916, 371-378
Copyright © 1989 by American Association for the Advancement of Science
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
PJ Mitchell
and
R Tjian
Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley 94720.
The cloning of genes encoding mammalian DNA binding transcription factors for RNA polymerase II has provided the opportunity to analyze the structure and function of these proteins. This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors. The mechanisms by which these factors may activate transcriptional initiation and by which they may be regulated to achieve differential gene expression are also discussed.
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- The Activation Domain of Herpesvirus Saimiri R Protein Interacts with the TATA-Binding Protein.
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J. Virol.
73, 9756-9763
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- CTp11, a Novel Member of the Family of Human Cancer/Testis Antigens.
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Cancer Res.
59, 6223-6229
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- Effects of methionine on endogenous antioxidants in the heart.
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Am J Physiol Heart Circ Physiol
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- The Role of Human MBF1 as a Transcriptional Coactivator.
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274, 34196-34202
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- Stimulation of DNA Replication in Saccharomyces cerevisiae by a Glutamine- and Proline-rich Transcriptional Activation Domain.
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274, 30310-30314
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- Three Conserved Transcriptional Repressor Domains Are a Defining Feature of the TIEG Subfamily of Sp1-like Zinc Finger Proteins.
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274, 29500-29504
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- The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.
- P. Rollini and R. E. K. Fournier (1999)
PNAS
96, 10308-10313
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- Phospholipase C-gamma 1 Is Required for Calcium-induced Keratinocyte Differentiation.
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J. Biol. Chem.
274, 20421-20424
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- Mpl Ligand Enhances the Transcription of the Cyclin D3 Gene: A Potential Role for Sp1 Transcription Factor.
- Z. Wang, Y. Zhang, J. Lu, S. Sun, and K. Ravid (1999)
Blood
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- Two Novel Kruppel-associated Box-containing Zinc-finger Proteins, KRAZ1 and KRAZ2, Repress Transcription through Functional Interaction with the Corepressor KAP-1 (TIF1beta /KRIP-1).
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274, 16412-16422
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