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Science 21 July 1989:
Vol. 245. no. 4915, pp. 308 - 310
DOI: 10.1126/science.2787531
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Articles

Science, Vol 245, Issue 4915, 308-310
Copyright © 1989 by American Association for the Advancement of Science

articles

Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice

RL Coffman, BW Seymour, S Hudak, J Jackson, and D Rennick

DNAX Research Institute, Palo Alto, CA 94304.

When rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the TH2 subset of CD4-expressing T cells.


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