Science 21 July 1989: Vol. 245. no. 4915, pp. 301 - 305 DOI: 10.1126/science.2787530

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Articles

Novel ways to sensitise gastrointestinal cancer to apoptosis.

H Schulze-Bergkamen, A Weinmann, M Moehler, J Siebler, and P R Galle (2009)
Gut 58, 1010-1024
 |  Abstract »  |  Full Text »  |  PDF »

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance.

M. Fakler, S. Loeder, M. Vogler, K. Schneider, I. Jeremias, K.-M. Debatin, and S. Fulda (2009)
Blood 113, 1710-1722
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CD95 Stimulation Results in the Formation of a Novel Death Effector Domain Protein-containing Complex.

I. N. Lavrik, T. Mock, A. Golks, J. C. Hoffmann, S. Baumann, and P. H. Krammer (2008)
J. Biol. Chem. 283, 26401-26408
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Juxtamembrane Domain in Tumor Necrosis Factor Receptor Superfamily Molecules Activates Rac1 and Controls Neurite Growth.

W. Ruan, C. T. Lee, and J. Desbarats (2008)
Mol. Biol. Cell 19, 3192-3202
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Construction of Optimized Bispecific Antibodies for Selective Activation of the Death Receptor CD95.

T. Herrmann, L. Grosse-Hovest, T. Otz, P. H. Krammer, H.-G. Rammensee, and G. Jung (2008)
Cancer Res. 68, 1221-1227
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Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes.

D. Brenner, A. Golks, M. Becker, W. Muller, C. R. Frey, R. Novak, D. Melamed, F. Kiefer, P. H. Krammer, and R. Arnold (2007)
Blood 110, 3968-3977
 |  Abstract »  |  Full Text »  |  PDF »

Fas Ligand-Dependent Inflammatory Regulation in Acute Myocarditis Induced by Trypanosoma cruzi Infection.

G. M. de Oliveira, R. L. Diniz, W. Batista, M. M. Batista, C. Bani Correa, T. C. de Araujo-Jorge, and A. Henriques-Pons (2007)
Am. J. Pathol. 171, 79-86
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Novel Role for Mitochondria: Protein Kinase C{theta}-Dependent Oxidative Signaling Organelles in Activation-Induced T-Cell Death.

M. Kaminski, M. Kiessling, D. Suss, P. H. Krammer, and K. Gulow (2007)
Mol. Cell. Biol. 27, 3625-3639
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Analysis of CD95 Threshold Signaling: TRIGGERING OF CD95 (FAS/APO-1) AT LOW CONCENTRATIONS PRIMARILY RESULTS IN SURVIVAL SIGNALING.

I. N. Lavrik, A. Golks, D. Riess, M. Bentele, R. Eils, and P. H. Krammer (2007)
J. Biol. Chem. 282, 13664-13671
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On the TRAIL Toward Death Receptor-Based Cancer Therapeutics.

T. F. Gajewski (2007)
J. Clin. Oncol. 25, 1305-1307
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The FLIP-Side of Fas Signaling.

M. L. Hyer, T. Samuel, and J. C. Reed (2006)
Clin. Cancer Res. 12, 5929-5931
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Death Ligands and Autoimmune Demyelination.

O. Aktas, T. Prozorovski, and F. Zipp (2006)
Neuroscientist 12, 305-316
 |  Abstract »  |  PDF »

Cyclooxygenase-2 Inhibition Induces Apoptosis Signaling via Death Receptors and Mitochondria in Hepatocellular Carcinoma..

M. A. Kern, A. M. Haugg, A. F. Koch, T. Schilling, K. Breuhahn, H. Walczak, B. Fleischer, C. Trautwein, C. Michalski, H. Schulze-Bergkamen, et al. (2006)
Cancer Res. 66, 7059-7066
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis.

I. N. Lavrik, A. Golks, S. Baumann, and P. H. Krammer (2006)
Blood 108, 559-565
 |  Abstract »  |  Full Text »  |  PDF »

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-{kappa}B activation.

A. Golks, D. Brenner, P. H. Krammer, and I. N. Lavrik (2006)
J. Exp. Med. 203, 1295-1305
 |  Abstract »  |  Full Text »  |  PDF »

HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP).

A. Krueger, S. C. Fas, M. Giaisi, M. Bleumink, A. Merling, C. Stumpf, S. Baumann, D. Holtkotte, V. Bosch, P. H. Krammer, et al. (2006)
Blood 107, 3933-3939
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Preclinical Differentiation between Apparently Safe and Potentially Hepatotoxic Applications of TRAIL Either Alone or in Combination with Chemotherapeutic Drugs.

T. M. Ganten, R. Koschny, J. Sykora, H. Schulze-Bergkamen, P. Buchler, T. L. Haas, M. B. Schader, A. Untergasser, W. Stremmel, and H. Walczak (2006)
Clin. Cancer Res. 12, 2640-2646
 |  Abstract »  |  Full Text »  |  PDF »

A Tumor Necrosis Factor Receptor 1-Dependent Conversation between Central Nervous System-Specific T Cells and the Central Nervous System Is Required for Inflammatory Infiltration of the Spinal Cord.

M. A. Gimenez, J. Sim, A. S. Archambault, R. S. Klein, and J. H. Russell (2006)
Am. J. Pathol. 168, 1200-1209
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CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia.

E. Bremer, B. t. Cate, D. F. Samplonius, L. F. M. H. de Leij, and W. Helfrich (2006)
Blood 107, 2863-2870
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD95-Mediated Adipocyte Loss in Autoimmune Lipodystrophy.

P. Fischer-Posovszky, H. Hebestreit, A. K. Hofmann, G. Strauss, P. Moller, K.-M. Debatin, and M. Wabitsch (2006)
J. Clin. Endocrinol. Metab. 91, 1129-1135
 |  Abstract »  |  Full Text »  |  PDF »

Fas costimulation of naive CD4 T cells is controlled by NF-{kappa}B signaling and caspase activity.

M. Maksimow, T. S. Soderstrom, S. Jalkanen, J. E. Eriksson, and A. Hanninen (2006)
J. Leukoc. Biol. 79, 369-377
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The Endoplasmic Reticulum Is a Key Component of the Plasma Cell Death Pathway.

N. Pelletier, M. Casamayor-Palleja, K. De Luca, P. Mondiere, F. Saltel, P. Jurdic, C. Bella, L. Genestier, and T. Defrance (2006)
J. Immunol. 176, 1340-1347
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Caspase and Bid Involvement in Clostridium difficile Toxin A-Induced Apoptosis and Modulation of Toxin A Effects by Glutamine and Alanyl-Glutamine In Vivo and In Vitro.

B. A. Carneiro, J. Fujii, G. A. C. Brito, C. Alcantara, R. B. Oria, A. A. M. Lima, T. Obrig, and R. L. Guerrant (2006)
Infect. Immun. 74, 81-87
 |  Abstract »  |  Full Text »  |  PDF »

A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells.

J. Nakayama, Y. Ogawa, Y. Yoshigae, Y. Onozawa, A. Yonemura, M. Saito, K. Ichikawa, T. Yamoto, T. Komai, T. Tatsuta, et al. (2006)
Int. Immunol. 18, 113-124
 |  Abstract »  |  Full Text »  |  PDF »

c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis.

A. Golks, D. Brenner, C. Fritsch, P. H. Krammer, and I. N. Lavrik (2005)
J. Biol. Chem. 280, 14507-14513
 |  Abstract »  |  Full Text »  |  PDF »

Biological impediments to monoclonal antibody-based cancer immunotherapy.

J. Christiansen and A. K. Rajasekaran (2004)
Mol. Cancer Ther. 3, 1493-1501
 |  Abstract »  |  Full Text »  |  PDF »

Immune activation in severe heart failure: Does etiology play a role?.

L. Agnoletti, S. Curello, F. Malacarne, P. Airò, A. Cargnoni, M. Valgimigli, and R. Ferrari (2004)
Eur. Heart J. Suppl. 6, F22-F29
 |  Abstract »  |  Full Text »  |  PDF »

Novel Negative Regulator of Expression in Fas Ligand (CD178) Cytoplasmic Tail: Evidence for Translational Regulation and against Fas Ligand Retention in Secretory Lysosomes.

S. Xiao, U. S. Deshmukh, S. Jodo, T. Koike, R. Sharma, A. Furusaki, S.-s. J. Sung, and S.-T. Ju (2004)
J. Immunol. 173, 5095-5102
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Polymorphisms of Death Pathway Genes FAS and FASL in Esophageal Squamous-Cell Carcinoma.

T. Sun, X. Miao, X. Zhang, W. Tan, P. Xiong, and D. Lin (2004)
J Natl Cancer Inst 96, 1030-1036
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In vivo inhibition of neutrophil activity by a FAS (CD95) stimulating module: Arterial in-line application in a porcine cardiac surgery model.

M. Scholz, A. Simon, M. Berg, A. M. Schuller, M. Hacibayramoglu, S. Margraf, A. Theisen, J. Windolf, G. Wimmer-Greinecker, and A. Moritz (2004)
J. Thorac. Cardiovasc. Surg. 127, 1735-1742
 |  Abstract »  |  Full Text »  |  PDF »

Selection and characterization of HER2/neu-binding affibody ligands.

M. Wikman, A.-C. Steffen, E. Gunneriusson, V. Tolmachev, G.P. Adams, J. Carlsson, and S. Stahl (2004)
Protein Eng. Des. Sel. 17, 455-462
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Inhibition of Death-Receptor Mediated Apoptosis in Human Adipocytes by the Insulin-Like Growth Factor I (IGF-I)/IGF-I Receptor Autocrine Circuit.

P. Fischer-Posovszky, H. Tornqvist, K.-M. Debatin, and M. Wabitsch (2004)
Endocrinology 145, 1849-1859
 |  Abstract »  |  Full Text »  |  PDF »

FAS (CD95) Mutations Are Rare in Gastric MALT Lymphoma but Occur More Frequently in Primary Gastric Diffuse Large B-Cell Lymphoma.

S. Wohlfart, D. Sebinger, P. Gruber, J. Buch, D. Polgar, G. Krupitza, M. Rosner, M. Hengstschlager, M. Raderer, A. Chott, et al. (2004)
Am. J. Pathol. 164, 1081-1089
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Xenopus Death Receptor-M1 and -M2, New Members of the Tumor Necrosis Factor Receptor Superfamily, Trigger Apoptotic Signaling by Differential Mechanisms.

K. Tamura, T. Noyama, Y.-h. Ishizawa, N. Takamatsu, T. Shiba, and M. Ito (2004)
J. Biol. Chem. 279, 7629-7635
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Resistance of Short Term Activated T Cells to CD95-Mediated Apoptosis Correlates with De Novo Protein Synthesis of c-FLIPshort.

I. Schmitz, H. Weyd, A. Krueger, S. Baumann, S. C. Fas, P. H. Krammer, and S. Kirchhoff (2004)
J. Immunol. 172, 2194-2200
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IFN-{gamma} Promotes Fas Ligand- and Perforin-Mediated Liver Cell Destruction by Cytotoxic CD8 T Cells.

E. Roth and H. Pircher (2004)
J. Immunol. 172, 1588-1594
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-{beta}1 Induces Apoptosis through Fas Ligand-independent Activation of the Fas Death Pathway in Human Gastric SNU-620 Carcinoma Cells.

S. G. Kim, H.-S. Jong, T.-Y. Kim, J. W. Lee, N. K. Kim, S. H. Hong, and Y.-J. Bang (2004)
Mol. Biol. Cell 15, 420-434
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Osteoclast Apoptosis: The Role of Fas in Vivo and in Vitro.

X. Wu, M. A. McKenna, X. Feng, T. R. Nagy, and J. M. McDonald (2003)
Endocrinology 144, 5545-5555
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Two CD95 tumor classes with different sensitivities to antitumor drugs.

A. Algeciras-Schimnich, E. M. Pietras, B. C. Barnhart, P. Legembre, S. Vijayan, S. L. Holbeck, and M. E. Peter (2003)
PNAS 100, 11445-11450
 |  Abstract »  |  Full Text »  |  PDF »

An IL-2-Dependent Switch Between CD95 Signaling Pathways Sensitizes Primary Human T Cells Toward CD95-Mediated Activation-Induced Cell Death.

I. Schmitz, A. Krueger, S. Baumann, H. Schulze-Bergkamen, P. H. Krammer, and S. Kirchhoff (2003)
J. Immunol. 171, 2930-2936
 |  Abstract »  |  Full Text »  |  PDF »

Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell-surface Antigen-restricted Activation.

D. Samel, D. Muller, J. Gerspach, C. Assohou-Luty, G. Sass, G. Tiegs, K. Pfizenmaier, and H. Wajant (2003)
J. Biol. Chem. 278, 32077-32082
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Caspase Activation and Impaired Death-Inducing Signaling Complex Formation in CD95-Resistant, Long-Term Activated, Antigen-Specific T Cells.

G. Strauss, I. Knape, I. Melzner, and K.-M. Debatin (2003)
J. Immunol. 171, 1172-1182
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IgD-receptor (IgD-R) cross-linking partially protects murine T cells from dexamethasone-induced apoptosis.

S. M. L. Tamma and R. F. Coico (2003)
J. Leukoc. Biol. 73, 764-770
 |  Abstract »  |  Full Text »  |  PDF »

Nitrosylation of Cytochrome c during Apoptosis.

C. M. Schonhoff, B. Gaston, and J. B. Mannick (2003)
J. Biol. Chem. 278, 18265-18270
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TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.

K. Uno, T. Inukai, N. Kayagaki, K. Goi, H. Sato, A. Nemoto, K. Takahashi, K. Kagami, N. Yamaguchi, H. Yagita, et al. (2003)
Blood 101, 3658-3667
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Localization of Keratinocyte Fas Ligand Explains Lack of Cytolytic Activity under Physiological Conditions.

I. Viard-Leveugle, R. R. Bullani, P. Meda, O. Micheau, A. Limat, J.-H. Saurat, J. Tschopp, and L. E. French (2003)
J. Biol. Chem. 278, 16183-16188
 |  Abstract »  |  Full Text »  |  PDF »

Concentrations of Soluble Fas in Maternal Serum and Amniotic Fluid During Uncomplicated Pregnancies.

A. Malamitsi-Puchner, A. Sarandakou, V. Papagianni, E. Protonotarious, J. Tziotis, and D. Botsis (2003)
Reproductive Sciences 10, 158-160
 |  Abstract »  |  PDF »

Calcium/Calmodulin-dependent Protein Kinase II Regulation of c-FLIP Expression and Phosphorylation in Modulation of Fas-mediated Signaling in Malignant Glioma Cells.

B. F. Yang, C. Xiao, W. H. Roa, P. H. Krammer, and C. Hao (2003)
J. Biol. Chem. 278, 7043-7050
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Signaling Mechanism for Soluble CD95 Ligand. SYNERGY WITH ANTI-CD95 MONOCLONAL ANTIBODIES FOR APOPTOSIS AND NF-kappa B NUCLEAR TRANSLOCATION.

S. Xiao, S. Jodo, S.-s. J. Sung, A. Marshak-Rothstein, and S.-T. Ju (2002)
J. Biol. Chem. 277, 50907-50913
 |  Abstract »  |  Full Text »  |  PDF »

Sensitivity of Photoreceptor-Derived Cell Line (661W) to Baculoviral p35, Z-VAD.FMK, and Fas-Associated Death Domain.

G. Tuohy, S. Millington-Ward, P. F. Kenna, P. Humphries, and G. J. Farrar (2002)
Invest. Ophthalmol. Vis. Sci. 43, 3583-3589
 |  Abstract »  |  Full Text »  |  PDF »

The Human Papillomavirus Type 16 E5 Protein Impairs TRAIL- and FasL-Mediated Apoptosis in HaCaT Cells by Different Mechanisms.

K. Kabsch and A. Alonso (2002)
J. Virol. 76, 12162-12172
 |  Abstract »  |  Full Text »  |  PDF »

FasL Deficiency Enhances the Development of Tumors in p53+/- Mice.

M. Embree-Ku and K. Boekelheide (2002)
Toxicol Pathol 30, 705-713
 |  Abstract »  |  PDF »

A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries.

H. Kawasaki and K. Taira (2002)
Nucleic Acids Res. 30, 3609-3614
 |  Abstract »  |  Full Text »  |  PDF »

DNA Ligase III Is Degraded by Calpain during Cell Death Induced by DNA-damaging Agents.

L. Bordone and C. Campbell (2002)
J. Biol. Chem. 277, 26673-26680
 |  Abstract »  |  Full Text »  |  PDF »

Plasma from Cancer Patients Featuring a Characteristic Protein Composition Mediates Protection against Apoptosis.

S. Vejda, C. Posovszky, S. Zelzer, B. Peter, E. Bayer, D. Gelbmann, R. Schulte-Hermann, and C. Gerner (2002)
Mol. Cell. Proteomics 1, 387-393
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor Receptor 1 Is an ATPase Regulated by Silencer of Death Domain.

K. Miki and E. M. Eddy (2002)
Mol. Cell. Biol. 22, 2536-2543
 |  Abstract »  |  Full Text »  |  PDF »

Glutathione Dependence of Caspase-8 Activation at the Death-inducing Signaling Complex.

H. Hentze, I. Schmitz, M. Latta, A. Krueger, P. H. Krammer, and A. Wendel (2002)
J. Biol. Chem. 277, 5588-5595
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Ordering of the Initial Signaling Events of CD95.

A. Algeciras-Schimnich, L. Shen, B. C. Barnhart, A. E. Murmann, J. K. Burkhardt, and M. E. Peter (2002)
Mol. Cell. Biol. 22, 207-220
 |  Abstract »  |  Full Text »  |  PDF »

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis.

A. Krueger, S. Baumann, P. H. Krammer, and S. Kirchhoff (2001)
Mol. Cell. Biol. 21, 8247-8254
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Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus (SLE): relation to lymphocyte activation and disease activity.

M Bijl, G Horst, P C Limburg, and C G. Kallenberg (2001)
Lupus 10, 866-872
 |  Abstract »  |  PDF »

Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES.

S. Jodo, S. Xiao, A. Hohlbaum, D. Strehlow, A. Marshak-Rothstein, and S.-T. Ju (2001)
J. Biol. Chem. 276, 39938-39944
 |  Abstract »  |  Full Text »  |  PDF »

Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction.

C. D. Riffkin, A. Z. Gray, C. J. Hawkins, C.W. Chow, and D. M. Ashley (2001)
Neuro-oncol 3, 229-240
 |  Abstract »  |  PDF »

Vacuolating Cytotoxin of Helicobacter pylori Induces Apoptosis in the Human Gastric Epithelial Cell Line AGS.

D. Kuck, B. Kolmerer, C. Iking-Konert, P. H. Krammer, W. Stremmel, and J. Rudi (2001)
Infect. Immun. 69, 5080-5087
 |  Abstract »  |  Full Text »  |  PDF »

A Monoclonal Antibody That Induces Neuronal Apoptosis Binds a Metastasis Marker.

L.-t. Zhong, A. Manzi, E. Skowronski, L. Notterpek, A. L. Fluharty, K. F. Faull, I. Masada, S. Rabizadeh, M. Varsanyi-Nagy, Y. Ruan, et al. (2001)
Cancer Res. 61, 5741-5748
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide Inhibits the Transcription Repressor Yin-Yang 1 Binding Activity at the Silencer Region of the Fas Promoter: A Pivotal Role for Nitric Oxide in the Up-Regulation of Fas Gene Expression in Human Tumor Cells.

H. J. Garban and B. Bonavida (2001)
J. Immunol. 167, 75-81
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3'-Kinase Blocks CD95 Aggregation and Caspase-8 Cleavage at the Death-Inducing Signaling Complex by Modulating Lateral Diffusion of CD95.

A. S. Varadhachary, M. Edidin, A. M. Hanlon, M. E. Peter, P. H. Krammer, and P. Salgame (2001)
J. Immunol. 166, 6564-6569
 |  Abstract »  |  Full Text »  |  PDF »

Expression of apoptosis on rat liver by hepatic vagus hyperactivity after ventromedial hypothalamic lesioning.

T. Kiba, S. Saito, K. Numata, Y. Kon, T. Mizutani, and H. Sekihara (2001)
Am J Physiol Gastrointest Liver Physiol 280, G958-G967
 |  Abstract »  |  Full Text »  |  PDF »

Autocrine cell suicide in a Burkitt lymphoma cell line (Daudi) induced by interferon {alpha}: involvement of tumor necrosis factor as ligand for the CD95 receptor.

H. Gisslinger, R. Kurzrock, B. Gisslinger, S. Jiang, S. Li, I. Virgolini, W. Woloszczuk, M. Andreeff, and M. Talpaz (2001)
Blood 97, 2791-2797
 |  Abstract »  |  Full Text »  |  PDF »

Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4.

A. Chuntharapai, K. Dodge, K. Grimmer, K. Schroeder, S. A. Marsters, H. Koeppen, A. Ashkenazi, and K. J. Kim (2001)
J. Immunol. 166, 4891-4898
 |  Abstract »  |  Full Text »  |  PDF »

Target Cell-restricted Triggering of the CD95 (APO-1/Fas) Death Receptor with Bispecific Antibody Fragments.

G. Jung, L. Grosse-Hovest, P. H. Krammer, and H.-G. Rammensee (2001)
Cancer Res. 61, 1846-1848
 |  Abstract »  |  Full Text »

FLICE-inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis.

A. Hennino, M. Berard, P. H. Krammer, and T. Defrance (2001)
J. Exp. Med. 193, 447-458
 |  Abstract »  |  Full Text »  |  PDF »

Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand.

K. L. Serrao, J. D. Fortenberry, M. L. Owens, F. L. Harris, and L. A. S. Brown (2001)
Am J Physiol Lung Cell Mol Physiol 280, L298-L305
 |  Abstract »  |  Full Text »  |  PDF »

Complete Regression of Established Spontaneous Mammary Carcinoma and the Therapeutic Prevention of Genetically Programmed Neoplastic Transition by IL-12/Pulse IL-2: Induction of Local T Cell Infiltration, Fas/Fas Ligand Gene Expression, and Mammary Epithelial Apoptosis.

J. M. Wigginton, J.-W. Park, M. E. Gruys, H. A. Young, C. L. Jorcyk, T. C. Back, M. J. Brunda, R. M. Strieter, J. Ward, J. E. Green, et al. (2001)
J. Immunol. 166, 1156-1168
 |  Abstract »  |  Full Text »  |  PDF »

HSP70 from Trypanosoma cruzi is endowed with specific cell proliferation potential leading to apoptosis.

C. Maranon, L. Planelles, C. Alonso, and M. C. Lopez (2000)
Int. Immunol. 12, 1685-1693
 |  Abstract »  |  Full Text »  |  PDF »

TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity.

S. Kirchhoff, W. W. Muller, A. Krueger, I. Schmitz, and P. H. Krammer (2000)
J. Immunol. 165, 6293-6300
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis Induced by Rac GTPase Correlates with Induction of FasL and Ceramides Production.

N. Embade, P. F. Valerón, S. Aznar, E. López-Collazo, and J. C. Lacal (2000)
Mol. Biol. Cell 11, 4347-4358
 |  Abstract »  |  Full Text »

Induction of Fas Expression and Augmentation of Fas/Fas Ligand-mediated Apoptosis by the Synthetic Retinoid CD437 in Human Lung Cancer Cells.

S.-Y. Sun, P. Yue, W. K. Hong, and R. Lotan (2000)
Cancer Res. 60, 6537-6543
 |  Abstract »  |  Full Text »  |  PDF »

Proteolysis of the human DNA polymerase {varepsilon} catalytic subunit by caspase-3 and calpain specifically during apoptosis.

W. Liu and S. Linn (2000)
Nucleic Acids Res. 28, 4180-4188
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Fas Death Pathway by FLICE-Inhibitory Protein in Primary Human B Cells.

A. Hennino, M. Berard, M. Casamayor-Palleja, P. H. Krammer, and T. Defrance (2000)
J. Immunol. 165, 3023-3030
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Immunolocalization of Fas and Fas ligand in the ovaries of women with polycystic ovary syndrome: relationship to apoptosis.

N. A. Cataldo, D. A. Dumesic, P. C. Goldsmith, and R. B. Jaffe (2000)
Hum. Reprod. 15, 1889-1897
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Fas Ligand-Induced c-Jun Kinase Activation in Lymphoid Cells Requires Extensive Receptor Aggregation But Is Independent of DAXX, and Fas-Mediated Cell Death Does Not Involve DAXX, RIP, or RAIDD.

A. Villunger, D. C. S. Huang, N. Holler, J. Tschopp, and A. Strasser (2000)
J. Immunol. 165, 1337-1343
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Metabolic Inhibitors Sensitize for CD95 (APO-1/Fas)-induced Apoptosis by Down-Regulating Fas-associated Death Domain-like Interleukin 1-Converting Enzyme Inhibitory Protein Expression.

S. Fulda, E. Meyer, and K.-M. Debatin (2000)
Cancer Res. 60, 3947-3956
 |  Abstract »  |  Full Text »

Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice.

A. S. Eaton-Bassiri, L. Mandik-Nayak, S.-j. Seo, M. P. Madaio, M. P. Cancro, and J. Erikson (2000)
Int. Immunol. 12, 915-926
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Bioactivities of Fas Ligand-Expressing Retroviral Particles.

S. Jodo, D. Strehlow, and S.-T. Ju (2000)
J. Immunol. 164, 5062-5069
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The Prodomain of Caspase-1 Enhances Fas-mediated Apoptosis through Facilitation of Caspase-8 Activation.

T. Tatsuta, A. Shiraishi, and J. D. Mountz (2000)
J. Biol. Chem. 275, 14248-14254
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Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging.

F. F. Fagnoni, R. Vescovini, G. Passeri, G. Bologna, M. Pedrazzoni, G. Lavagetto, A. Casti, C. Franceschi, M. Passeri, and P. Sansoni (2000)
Blood 95, 2860-2868
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A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity.

K. Ichikawa, H. Yoshida-Kato, M. Ohtsuki, J. Ohsumi, J. Yamaguchi, S. Takahashi, Y. Tani, M. Watanabe, A. Shiraishi, K. Nishioka, et al. (2000)
Int. Immunol. 12, 555-562
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Cytochrome c Is Involved in Fas-mediated Apoptosis of Prostatic Carcinoma Cell Lines.

A. Gewies, O. W. Rokhlin, and M. B. Cohen (2000)
Cancer Res. 60, 2163-2168
 |  Abstract »  |  Full Text »

Role of Activator Protein-1 in TCR-Mediated Regulation of the Murine fasl Promoter.

K. Matsui, S. Xiao, A. Fine, and S.-T. Ju (2000)
J. Immunol. 164, 3002-3008
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Comparison of Fas- versus perforin-mediated pathways of cytotoxicity in TCR- and Thy-1-activated murine T cells.

H. Kojima, M. Toda, and M. V. Sitkovsky (2000)
Int. Immunol. 12, 365-374
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Serum levels of soluble Fas correlate with indices of organ damage in systemic lupus erythematosus.

M. H Al-Maini, J. D Mountz, H. A Al-Mohri, E. M El-Ageb, B. M Al-Riyami, K. L G Svenson, T. Zhou, and E. R Richens (2000)
Lupus 9, 132-139
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Phosphorylation of FADD/ MORT1 at Serine 194 and Association with a 70-kDa Cell Cycle-Regulated Protein Kinase.

C. Scaffidi, J. Volkland, I. Blomberg, I. Hoffmann, P. H. Krammer, and M. E. Peter (2000)
J. Immunol. 164, 1236-1242
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Differential susceptibility of human Th1 versus T h 2 cells to induction of anergy and apoptosis by ECDI/antigen-coupled antigen-presenting cells.

A. A. Vandenbark, D. Barnes, T. Finn, D. N. Bourdette, R. Whitham, I. Robey, J. Kaleeba, B. F. Bebo Jr, S. D. Miller, H. Offner, et al. (2000)
Int. Immunol. 12, 57-66
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Drug-induced Apoptosis in Lung Cancer Cells Is Not Mediated by the Fas/FasL (CD95/APO1) Signaling Pathway.

C. G. Ferreira, C. Tolis, S. W. Span, G. J. Peters, T. van Lopik, A. J. Kummer, H. M. Pinedo, and G. Giaccone (2000)
Clin. Cancer Res. 6, 203-212
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IFN-{gamma}-Dependent Delay of In Vivo Tumor Progression by Fas Overexpression on Murine Renal Cancer Cells.

J.-K. Lee, T. J. Sayers, A. D. Brooks, T. C. Back, H. A. Young, K. L. Komschlies, J. M. Wigginton, and R. H. Wiltrout (2000)
J. Immunol. 164, 231-239
 |  Abstract »  |  Full Text »  |  PDF »

Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells.

S. Fulda, G. Strauss, E. Meyer, and K.-M. Debatin (2000)
Blood 95, 301-308
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL.

D. C. S. Huang, M. Hahne, M. Schroeter, K. Frei, A. Fontana, A. Villunger, K. Newton, J. Tschopp, and A. Strasser (1999)
PNAS 96, 14871-14876
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FADD Is Required for Multiple Signaling Events Downstream of the Receptor Fas.

P. Juo, M. Sue-Ann Woo, C. J. Kuo, P. Signorelli, H. P. Biemann, Y. A. Hannun, and J. Blenis (1999)
Cell Growth Differ. 10, 797-804
 |  Abstract »  |  Full Text »

Human RNA Helicase A Is a Lupus Autoantigen That Is Cleaved During Apoptosis.

Y. Takeda, P. Caudell, G. Grady, G. Wang, A. Suwa, G. C. Sharp, W. S. Dynan, and J. A. Hardin (1999)
J. Immunol. 163, 6269-6274
 |  Abstract »  |  Full Text »  |  PDF »

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