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Science 14 July 1989:
Vol. 245. no. 4914, pp. 192 - 194
DOI: 10.1126/science.2749258
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Articles

Science, Vol 245, Issue 4914, 192-194
Copyright © 1989 by American Association for the Advancement of Science

articles

Neural connections between the lateral geniculate nucleus and visual cortex in vitro

N Yamamoto, T Kurotani, and K Toyama

Department of Physiology, Kyoto Prefectural School of Medicine, Japan.

Neural connections were established in cocultures of rat visual cortex (VC) and lateral geniculate nucleus (LGN), which were isolated in early infancy. Morphological and electrophysiological studies showed that the cortical laminar organization of afferent and efferent connections in the coculture preparations was similar to that in the adult VC. The results indicate the existence of intrinsic mechanisms in VC and LGN that guide the formation of synaptic connections with the appropriate targets.


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