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Science 14 July 1989:
Vol. 245. no. 4914, pp. 183 - 186
DOI: 10.1126/science.2749255
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Articles

Science, Vol 245, Issue 4914, 183-186
Copyright © 1989 by American Association for the Advancement of Science

articles

Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries

GS Worthen, B Schwab 3rd, EL Elson, and GP Downey

Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO.

The effect of peptide chemoattractants on neutrophil mechanical properties was studied to test the hypothesis that stimulated neutrophils (diameter, 8 micrometers) are retained in pulmonary capillaries (5.5 micrometers) as a result of a decreased ability of the cell to deform within the capillary in response to the hydrodynamic forces of the bloodstream. Increased neutrophil stiffness, actin assembly, and retention in both 5-micrometer pores and the pulmonary vasculature were seen in response to N-formyl-methionyl-leucyl-phenylalanine. These changes were abolished in cells that had been incubated with 2 micromolar cytochalasin D, an agent that disrupts cellular actin organization. A monoclonal antibody directed at the CD11-CD18 adhesive glycoprotein complex did not inhibit the increase in stiffness or retention in pores. These data suggest that neutrophil stiffening may be both necessary and sufficient for the retention that is observed. Hence, neutrophil sequestration in lung and other capillaries in the acute inflammatory process may be the result of increased stiffness stimulated by chemoattractants.


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Potential Significance of Circulating E-Selectin.
C. Wayne Smith (1997)
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Fibroblast Contractility without an Increase in Basal Myosin Light Chain Phosphorylation in Wild Type Cells and Cells Expressing the Catalytic Domain of Myosin Light Chain Kinase.
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Role of Neutrophils in Myocardial Ischemia and Reperfusion.
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Beneficial Cardiopulmonary Effects of Pentoxifylline in Experimental Sepsis Are Lost Once Septic Shock Is Established.
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Delayed Tumor Necrosis Factor {alpha} Blockade Attenuates Pulmonary Dysfunction and Metabolic Acidosis Associated With Experimental Gram-negative Sepsis.
A. C. J. Windsor, P. G. Mullen, C. J. Walsh, B. J. Fisher, C. R. Blocher, G. Jesmok, A. A. Fowler III, and H. J. Sugerman (1994)
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The Damaging Potential of Leukocyte Activation in the Microcirculation.
G. W. Schmid-Schonbein (1993)
Angiology 44, 45-56
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Phosphodiesterase type 4 inhibitor reduces the retention of polymorphonuclear leukocytes in the lung.
Y. Sato, S. Sato, T. Yamamoto, S. Ishikawa, M. Onizuka, and Y. Sakakibara (2002)
Am J Physiol Lung Cell Mol Physiol 282, L1376-L1381
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L-selectin is required for fMLP- but not C5a-induced margination of neutrophils in pulmonary circulation.
T. S. Olson, K. Singbartl, and K. Ley (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R1245-R1252
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