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Science 14 July 1989:
Vol. 245. no. 4914, pp. 177 - 180
DOI: 10.1126/science.2501869

Articles

Science, Vol 245, Issue 4914, 177-180
Copyright © 1989 by American Association for the Advancement of Science


articles

Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle

NB Standen, JM Quayle, NW Davies, JE Brayden, Y Huang, and MT Nelson

Department of Physiology, University of Leicester, United Kingdom.

Vasodilators are used clinically for the treatment of hypertension and heart failure. The effects of some vasodilators seem to be mediated by membrane hyperpolarization. The molecular basis of this hyperpolarization has been investigated by examining the properties of single K+ channels in arterial smooth muscle cells. The presence of adenosine triphosphate (ATP)-sensitive K+ channels in these cells was demonstrated at the single channel level. These channels were opened by the hyperpolarizing vasodilator cromakalim and inhibited by the ATP-sensitive K+ channel blocker glibenclamide. Furthermore, in arterial rings the vasorelaxing actions of the drugs diazoxide, cromakalim, and pinacidil and the hyperpolarizing actions of vasoactive intestinal polypeptide and acetylcholine were blocked by inhibitors of the ATP-sensitive K+ channels, suggesting that all these agents may act through a common pathway in smooth muscle by opening ATP-sensitive K+ channels.


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Distribution and Physiological Roles of ATP-Sensitive K+ Channels in the Vertebrobasilar System of the Rabbit.
T. Nagao, S. Ibayashi, S. Sadoshima, K. Fujii, K. Fujii, Y. Ohya, and M. Fujishima (1996)
Circ. Res. 78, 238-243
   Abstract »    Full Text »
Acidosis-Induced Coronary Arteriolar Dilation Is Mediated by ATP-Sensitive Potassium Channels in Vascular Smooth Muscle.
H. Ishizaka and L. Kuo (1996)
Circ. Res. 78, 50-57
   Abstract »    Full Text »
Divergent Mechanisms of ATP-Sensitive K+ Channel–Induced Vasodilation in Renal Afferent and Efferent Arterioles : Evidence of L-Type Ca2+ Channel–Dependent and –Independent Actions of Pinacidil.
M. Reslerova and R. Loutzenhiser (1995)
Circ. Res. 77, 1114-1120
   Abstract »    Full Text »
Endothelium-Dependent Hyperpolarization : Beyond Nitric Oxide and Cyclic GMP.
R. A. Cohen and P. M. Vanhoutte (1995)
Circulation 92, 3337-3349
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ADENOSINE TRIPHOSPHATE-SENSITIVE K+ CHANNELS MEDIATE POSTCARDIOPLEGIA CORONARY HYPEREMIA.
S. Y. Wang, M. Friedman, R. G. Johnson, A. J. Zeind, and F. W. Sellke (1995)
J. Thorac. Cardiovasc. Surg. 110, 1073-1082
   Abstract »    Full Text »
Role of Potassium Channels in Cerebral Blood Vessels.
T. Kitazono, F. M. Faraci, H. Taguchi, and D. D. Heistad (1995)
Stroke 26, 1713-1723
   Abstract »    Full Text »
Voltage-Gated K+ Currents Regulate Resting Membrane Potential and [Ca2+]i in Pulmonary Arterial Myocytes.
X.-J. Yuan (1995)
Circ. Res. 77, 370-378
   Abstract »    Full Text »
Glibenclamide, a Selective Inhibitor of ATP-Sensitive K+ Channels, Attenuates Metabolic Coronary Vasodilatation Induced by Pacing Tachycardia in Dogs.
Y. Katsuda, K. Egashira, H. Ueno, Y. Akatsuka, T. Narishige, Y. Arai, T. Takayanagi, H. Shimokawa, and A. Takeshita (1995)
Circulation 92, 511-517
   Abstract »    Full Text »
Cerebral ATP-Sensitive Potassium Channels During Acute Reduction of Carotid Blood Flow.
M. Nishimura, H. Takahashi, A. Nanbu, M. Sakamoto, T. Nakanishi, and M. Yoshimura (1995)
Hypertension 25, 1069-1074
   Abstract »    Full Text »



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