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Science 14 July 1989: Vol. 245. no. 4914, pp. 177 - 180 DOI: 10.1126/science.2501869
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Articles
Science, Vol 245, Issue 4914, 177-180
Copyright © 1989 by American Association for the Advancement of Science
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle
NB Standen,
JM Quayle,
NW Davies,
JE Brayden,
Y Huang,
and
MT Nelson
Department of Physiology, University of Leicester, United Kingdom.
Vasodilators are used clinically for the treatment of hypertension and heart failure. The effects of some vasodilators seem to be mediated by membrane hyperpolarization. The molecular basis of this hyperpolarization has been investigated by examining the properties of single K+ channels in arterial smooth muscle cells. The presence of adenosine triphosphate (ATP)-sensitive K+ channels in these cells was demonstrated at the single channel level. These channels were opened by the hyperpolarizing vasodilator cromakalim and inhibited by the ATP-sensitive K+ channel blocker glibenclamide. Furthermore, in arterial rings the vasorelaxing actions of the drugs diazoxide, cromakalim, and pinacidil and the hyperpolarizing actions of vasoactive intestinal polypeptide and acetylcholine were blocked by inhibitors of the ATP-sensitive K+ channels, suggesting that all these agents may act through a common pathway in smooth muscle by opening ATP-sensitive K+ channels.
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- Altered Cerebrovascular Response to a Potassium Channel Opener in Hypertensive Rats.
- H. Takaba, T. Nagao, S. Ibayashi, T. Kitazono, K. Fujii, and M. Fujishima (1996)
Hypertension
28, 143-146
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- Impaired Action of Levcromakalim on ATP-Sensitive K+ Channels in Mesenteric Artery Cells From Spontaneously Hypertensive Rats.
- Y. Ohya, M. Setoguchi, K. Fujii, T. Nagao, I. Abe, and M. Fujishima (1996)
Hypertension
27, 1234-1239
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- Expression and Function of Voltage-dependent Potassium Channel Genes in Human Airway Smooth Muscle.
- S. Adda, B. K. Fleischmann, B. D. Freedman, M.-f. Yu, D. W. P. Hay, and M. I. Kotlikoff (1996)
J. Biol. Chem.
271, 13239-13243
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- REVIEW {blacksquare} : ATP-sensitive Potassium Channels: Diverse Functions in the Central Nervous System.
- J. E. Freedman and Y.-J. Lin (1996)
Neuroscientist
2, 145-152
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- K+ Currents in Human Coronary Artery Vascular Smooth Muscle Cells.
- M. Gollasch, C. Ried, R. Bychkov, F. C. Luft, and H. Haller (1996)
Circ. Res.
78, 676-688
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- Endothelial Function in Deoxycorticosterone-NaCl Hypertension : Effect of Calcium Supplementation.
- H. Makynen, M. Kahonen, X. Wu, P. Arvola, and I. Porsti (1996)
Circulation
93, 1000-1008
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- Distribution and Physiological Roles of ATP-Sensitive K+ Channels in the Vertebrobasilar System of the Rabbit.
- T. Nagao, S. Ibayashi, S. Sadoshima, K. Fujii, K. Fujii, Y. Ohya, and M. Fujishima (1996)
Circ. Res.
78, 238-243
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- Acidosis-Induced Coronary Arteriolar Dilation Is Mediated by ATP-Sensitive Potassium Channels in Vascular Smooth Muscle.
- H. Ishizaka and L. Kuo (1996)
Circ. Res.
78, 50-57
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- Divergent Mechanisms of ATP-Sensitive K+ Channel–Induced Vasodilation in Renal Afferent and Efferent Arterioles : Evidence of L-Type Ca2+ Channel–Dependent and –Independent Actions of Pinacidil.
- M. Reslerova and R. Loutzenhiser (1995)
Circ. Res.
77, 1114-1120
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- Endothelium-Dependent Hyperpolarization : Beyond Nitric Oxide and Cyclic GMP.
- R. A. Cohen and P. M. Vanhoutte (1995)
Circulation
92, 3337-3349
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- ADENOSINE TRIPHOSPHATE-SENSITIVE K+ CHANNELS MEDIATE POSTCARDIOPLEGIA CORONARY HYPEREMIA.
- S. Y. Wang, M. Friedman, R. G. Johnson, A. J. Zeind, and F. W. Sellke (1995)
J. Thorac. Cardiovasc. Surg.
110, 1073-1082
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- Role of Potassium Channels in Cerebral Blood Vessels.
- T. Kitazono, F. M. Faraci, H. Taguchi, and D. D. Heistad (1995)
Stroke
26, 1713-1723
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- Voltage-Gated K+ Currents Regulate Resting Membrane Potential and [Ca2+]i in Pulmonary Arterial Myocytes.
- X.-J. Yuan (1995)
Circ. Res.
77, 370-378
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- Glibenclamide, a Selective Inhibitor of ATP-Sensitive K+ Channels, Attenuates Metabolic Coronary Vasodilatation Induced by Pacing Tachycardia in Dogs.
- Y. Katsuda, K. Egashira, H. Ueno, Y. Akatsuka, T. Narishige, Y. Arai, T. Takayanagi, H. Shimokawa, and A. Takeshita (1995)
Circulation
92, 511-517
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- Cerebral ATP-Sensitive Potassium Channels During Acute Reduction of Carotid Blood Flow.
- M. Nishimura, H. Takahashi, A. Nanbu, M. Sakamoto, T. Nakanishi, and M. Yoshimura (1995)
Hypertension
25, 1069-1074
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