Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Career Basics

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 July 1989:
Vol. 245. no. 4914, pp. 147 - 153
DOI: 10.1126/science.2526369
Prev | Table of Contents | Next

Articles

Science, Vol 245, Issue 4914, 147-153
Copyright © 1989 by American Association for the Advancement of Science

articles

Immunologic tolerance: collaboration between antigen and lymphokines

GJ Nossal

Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.

Immunologic tolerance is the process whereby limits are placed on the degree to which lymphocytes respond to an animal's inherent antigens. It is a quantitative rather than an absolute term, as some autoantibody formation is common. Contrary to early hopes, it is not due to some single, simple causative mechanism confined to early developmental stages of the fetal immune system. Rather, self-tolerance results from a variety of complementary mechanisms and feedback loops in the immune system and is thus best seen as part of the general process of immunoregulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CD40 Ligand Rescues Inhibitor of Differentiation 3-Mediated G1 Arrest Induced by Anti-IgM in WEHI-231 B Lymphoma Cells.
K. Hata, T. Yoshimoto, and J. Mizuguchi (2004)
J. Immunol. 173, 2453-2461
   Abstract »    Full Text »    PDF »
Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
T. Kundig, M. Bachmann, C DiPaolo, J. Simard, M Battegay, H Lother, A Gessner, K Kuhlcke, P. Ohashi, H Hengartner, et al. (1995)
Science 268, 1343-1347
   Abstract »    PDF »
Generation of Monoclonal Antibodies against Autologous Proteins in Gene-inactivated Mice.
P. J. Declerck, P. Carmeliet, M. Verstreken, F. D. Cock, and Dés. Collen (1995)
J. Biol. Chem. 270, 8397-8400
   Abstract »    Full Text »    PDF »
The influence of allogeneic cells on the human T and B cell repertoire.
J. van Rood and F. Claas (1990)
Science 248, 1388-1393
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)