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Science 30 June 1989:
Vol. 244. no. 4912, pp. 1558 - 1564
DOI: 10.1126/science.2472670
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Articles

Science, Vol 244, Issue 4912, 1558-1564
Copyright © 1989 by American Association for the Advancement of Science

articles

Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure

J Krupinski, F Coussen, HA Bakalyar, WJ Tang, PG Feinstein, K Orth, C Slaughter, RR Reed, and AG Gilman

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235.

Complementary DNA's that encode an adenylyl cyclase were isolated from a bovine brain library. Most of the deduced amino acid sequence of 1134 residues is divisible into two alternating sets of hydrophobic and hydrophilic domains. Each of the two large hydrophobic domains appears to contain six transmembrane spans. Each of the two large hydrophilic domains contains a sequence that is homologous to a single cytoplasmic domain of several guanylyl cyclases; these sequences may represent nucleotide binding sites. An unexpected topographical resemblance between adenylyl cyclase and various plasma membrane channels and transporters was observed. This structural complexity suggests possible, unappreciated functions for this important enzyme.


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Splice Variants of Type VIII Adenylyl Cyclase.
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Ca[IMAGE] Inhibition of Type III Adenylyl Cyclase in Vivo.
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R. Reddy, D. Smith, G. Wayman, Z. Wu, E. C. Villacres, and D. R. Storm (1995)
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Characteristics of the ß-Adrenergic Receptor Complex in the Epicardial Border Zone of the 5-Day Infarcted Canine Heart.
S. F. Steinberg, H. Zhang, E. Pak, G. Pagnotta, and P. A. Boyden (1995)
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Mutational Inactivation of the Catalytic Domain of Guanylate Cyclase-A Receptor.
Z.-H. Miao, D.-L. Song, J. G. Douglas, and C.-H. Chang (1995)
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Mammalian Membrane-bound Adenylyl Cyclases.
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Dominant Negative Mutations of the Guanylyl Cyclase-A Receptor.
D. K. Thompson and D. L. Garbers (1995)
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Regulation of Mammalian Adenylyl Cyclases by G-Protein {alpha} and {beta}{gamma} Subunits.
W.-J. Tang, J.A. Iniguez-Lluhi, S. Mumby, and A.G. Gilman (1992)
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H.R. Bourne, K.D. Lustig, Y.H. Wong, and B.R. Conklin (1992)
Cold Spring Harb Symp Quant Biol 57, 145-148
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Cold Spring Harb Symp Quant Biol 57, 155-161
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G-Protein-linked Signaling Pathways Mediate Development in Dictyostelium.
R.L. Johnson, R. Gundersen, D. Hereld, G.S. Pitt, S. Tugendreich, C.L. Saxe, A.R. Kimmel, and P.N. Devreotes (1992)
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Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits.
W. Tang and A. Gilman (1991)
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Diversity of G proteins in signal transduction.
M. Simon, M. Strathmann, and N Gautam (1991)
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Identification of a specialized adenylyl cyclase that may mediate odorant detection.
H. Bakalyar and R. Reed (1990)
Science 250, 1403-1406
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G Proteins and Regulation of Adenylyl Cyclase.
A. G. Gilman (1989)
JAMA 262, 1819-1825
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The protein kinase domain of the ANP receptor is required for signaling.
M Chinkers and D. Garbers (1989)
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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
J. Riordan, J. Rommens, B Kerem, N Alon, R Rozmahel, Z Grzelczak, J Zielenski, S Lok, N Plavsic, J. Chou, et al. (1989)
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Guanylyl Cyclase Activity Associated with Putative Bifunctional Integral Membrane Proteins in Plasmodium falciparum.
D. J. Carucci, A. A. Witney, D. K. Muhia, D. C. Warhurst, P. Schaap, M. Meima, J.-L. Li, M. C. Taylor, J. M. Kelly, and D. A. Baker (2000)
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