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Science 23 June 1989:
Vol. 244. no. 4911, pp. 1493 - 1496
DOI: 10.1126/science.2567533
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Articles

Science, Vol 244, Issue 4911, 1493-1496
Copyright © 1989 by American Association for the Advancement of Science

articles

Transfer RNA genes: landmarks for integration of mobile genetic elements in Dictyostelium discoideum

R Marschalek, T Brechner, E Amon-Bohm, and T Dingermann

Institut fur Biochemie der Medizinischen Fakultat, Universitat Erlangen-Nurnberg, Federal Republic of Germany.

In prokaryotes and eukaryotes mobile genetic elements frequently disrupt the highly conservative structures of chromosomes, which are responsible for storage of genetic information. The factors determining the site for integration of such elements are still unknown. Transfer RNA (tRNA) genes are associated in a highly significant manner with different putative mobile genetic elements in the cellular slime mold Dictyostelium discoideum. These results suggest that tRNA genes in D. discoideum, and probably tRNA genes generally in lower eukaryotes, may function as genomic landmarks for the integration of different transposable elements in a strictly position-specific manner.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protein Interactions Involved in tRNA Gene-Specific Integration of Dictyostelium discoideum Non-Long Terminal Repeat Retrotransposon TRE5-A.
T. Chung, O. Siol, T. Dingermann, and T. Winckler (2007)
Mol. Cell. Biol. 27, 8492-8501
   Abstract »    Full Text »    PDF »
Transposable Elements and Genome Organization: A Comprehensive Survey of Retrotransposons Revealed by the Complete Saccharomyces cerevisiae Genome Sequence.
J. M. Kim, S. Vanguri, J. D. Boeke, A. Gabriel, and D. F. Voytas (1998)
Genome Res. 8, 464-478
   Abstract »    Full Text »
Integration of the yeast retrotransposon Ty1 is targeted to regions upstream of genes transcribed by RNA polymerase III..
S E Devine and J D Boeke (1996)
Genes & Dev. 10, 620-633
   Abstract »    PDF »
Ty3 integrates within the region of RNA polymerase III transcription initiation..
D L Chalker and S B Sandmeyer (1992)
Genes & Dev. 6, 117-128
   Abstract »    PDF »
The Complex Repeats of Dictyostelium discoideum.
G. Glöckner, K. Szafranski, T. Winckler, T. Dingermann, M. A. Quail, E. Cox, L. Eichinger, A. A. Noegel, and A. Rosenthal (2001)
Genome Res. 11, 585-594
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)