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Science 23 June 1989:
Vol. 244. no. 4911, pp. 1487 - 1490
DOI: 10.1126/science.2660266
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Articles

Science, Vol 244, Issue 4911, 1487-1490
Copyright © 1989 by American Association for the Advancement of Science

articles

Protection against streptococcal pharyngeal colonization with a vaccinia: M protein recombinant

VA Fischetti, WM Hodges, and DE Hruby

Rockefeller University, New York, NY 10021.

Phagocytosis of group A streptococci requires type-specific antibodies directed against the variable determinants of the bacterial surface M protein molecule. As a step toward developing a broadly protective anti-streptococcal vaccine, a vaccinia virus (VV) recombinant was constructed that expresses the conserved region of the structural gene encoding the M6 molecule (VV:M6'). Mice immunized intranasally with the VV:M6' virus showed markedly reduced pharyngeal colonization by streptococci after intranasal and oral challenge with these bacteria. M protein-specific serum immunoglobulin G was significantly elevated in vaccinated animals and absent in controls. A similar approach may prove useful for the identification of protective determinants present on other bacterial and viral pathogens.


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