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Science 16 June 1989:
Vol. 244. no. 4910, pp. 1328 - 1333
DOI: 10.1126/science.2734611
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Articles

Science, Vol 244, Issue 4910, 1328-1333
Copyright © 1989 by American Association for the Advancement of Science

articles

Bright light induction of strong (type 0) resetting of the human circadian pacemaker

CA Czeisler, RE Kronauer, JS Allan, JF Duffy, ME Jewett, EN Brown, and JM Ronda

Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115.

The response of the human circadian pacemaker to light was measured in 45 resetting trials. Each trial consisted of an initial endogenous circadian phase assessment, a three-cycle stimulus which included 5 hours of bright light per cycle, and a final phase assessment. The stimulus induced strong (type 0) resetting, with responses highly dependent on the initial circadian phase of light exposure. The magnitude and direction of the phase shifts were modulated by the timing of exposure to ordinary room light, previously thought to be undetectable by the human pacemaker. The data indicate that the sensitivity of the human circadian pacemaker to light is far greater than previously recognized and have important implications for the therapeutic use of light in the management of disorders of circadian regulation.


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