Science 16 June 1989: Vol. 244. no. 4910, pp. 1288 - 1292 DOI: 10.1126/science.2660260

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Articles

Generation of Pig-Induced Pluripotent Stem Cells with a Drug-Inducible System.

Z. Wu, J. Chen, J. Ren, L. Bao, J. Liao, C. Cui, L. Rao, H. Li, Y. Gu, H. Dai, et al. (2009)
J Mol Cell Biol
 |  Abstract »  |  Full Text »  |  PDF »

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.

P. Langerak, P. H.L Krijger, M. R Heideman, P. C.M van den Berk, and H. Jacobs (2009)
Phil Trans R Soc B 364, 621-629
 |  Abstract »  |  Full Text »  |  PDF »

Emerging gene knockout technology in zebrafish: zinc-finger nucleases.

S. L. Amacher (2008)
Brief Funct Genomic Proteomic 7, 460-464
 |  Abstract »  |  Full Text »  |  PDF »

Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting.

S. Iiizumi, A. Kurosawa, S. So, Y. Ishii, Y. Chikaraishi, A. Ishii, H. Koyama, and N. Adachi (2008)
Nucleic Acids Res. 36, 6333-6342
 |  Abstract »  |  Full Text »  |  PDF »

Development of gene therapy for blood disorders.

A. W. Nienhuis (2008)
Blood 111, 4431-4444
 |  Abstract »  |  Full Text »  |  PDF »

Canine embryo-derived stem cells and models for human diseases.

M. R. Schneider, E. Wolf, J. Braun, H.-J. Kolb, and H. Adler (2008)
Hum. Mol. Genet. 17, R42-R47
 |  Abstract »  |  Full Text »  |  PDF »

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.

P. Langerak, A. O.H. Nygren, P. H.L. Krijger, P. C.M. van den Berk, and H. Jacobs (2007)
J. Exp. Med. 204, 1989-1998
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Construction of Transgenes in Drosophila.

H. Takeuchi, O. Georgiev, M. Fetchko, M. Kappeler, W. Schaffner, and D. Egli (2007)
Genetics 175, 2019-2028
 |  Abstract »  |  Full Text »  |  PDF »

Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells.

M. Aarts, M. Dekker, S. de Vries, A. van der Wal, and H. te Riele (2006)
Nucleic Acids Res. 34, e147
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells.

M. Kanatsu-Shinohara, M. Ikawa, M. Takehashi, N. Ogonuki, H. Miki, K. Inoue, Y. Kazuki, J. Lee, S. Toyokuni, M. Oshimura, et al. (2006)
PNAS 103, 8018-8023
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells.

S. So, Y. Nomura, N. Adachi, Y. Kobayashi, T. Hori, Y. Kurihara, and H. Koyama (2006)
Genes Cells 11, 363-371
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of True and Ectopic Gene Targeting Events at the Acetolactate Synthase Gene in Arabidopsis.

M. Endo, K. Osakabe, H. Ichikawa, and S. Toki (2006)
Plant Cell Physiol. 47, 372-379
 |  Abstract »  |  Full Text »  |  PDF »

Parameters determining the efficiency of gene targeting in the moss Physcomitrella patens.

Y. Kamisugi, A. C. Cuming, and D. J. Cove (2005)
Nucleic Acids Res. 33, e173
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis.

N. Hovelmeyer, Z. Hao, K. Kranidioti, G. Kassiotis, T. Buch, F. Frommer, L. von Hoch, D. Kramer, L. Minichiello, G. Kollias, et al. (2005)
J. Immunol. 175, 5875-5884
 |  Abstract »  |  Full Text »  |  PDF »

Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells.

S. Durai, M. Mani, K. Kandavelou, J. Wu, M. H. Porteus, and S. Chandrasegaran (2005)
Nucleic Acids Res. 33, 5978-5990
 |  Abstract »  |  Full Text »  |  PDF »

Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.

E. T. Wong, J. L Kolman, Y.-C. Li, L. D Mesner, W. Hillen, C. Berens, and G. M Wahl (2005)
Nucleic Acids Res. 33, e147
 |  Abstract »  |  Full Text »  |  PDF »

High-frequency gene targeting in Arabidopsis plants expressing the yeast RAD54 gene.

H. Shaked, C. Melamed-Bessudo, and A. A. Levy (2005)
PNAS 102, 12265-12269
 |  Abstract »  |  Full Text »  |  PDF »

Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference.

X. Coumoul, V. Shukla, C. Li, R.-H. Wang, and C.-X. Deng (2005)
Nucleic Acids Res. 33, e102
 |  Abstract »  |  Full Text »  |  PDF »

Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy.

A. M. Wobus and K. R. Boheler (2005)
Physiol Rev 85, 635-678
 |  Abstract »  |  Full Text »  |  PDF »

Targeted mutagenesis using zinc-finger nucleases in Arabidopsis.

A. Lloyd, C. L. Plaisier, D. Carroll, and G. N. Drews (2005)
PNAS 102, 2232-2237
 |  Abstract »  |  Full Text »  |  PDF »

The role of Cdx genes in the mammalian gut.

F Beck (2004)
Gut 53, 1394-1396
 |  Full Text »  |  PDF »

B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation.

S. Shulga-Morskaya, M. Dobles, M. E. Walsh, L. G. Ng, F. MacKay, S. P. Rao, S. L. Kalled, and M. L. Scott (2004)
J. Immunol. 173, 2331-2341
 |  Abstract »  |  Full Text »  |  PDF »

TIRC7 Deficiency Causes In Vitro and In Vivo Augmentation of T and B Cell Activation and Cytokine Response.

N. Utku, A. Boerner, A. Tomschegg, F. Bennai-Sanfourche, G.-C. Bulwin, T. Heinemann, J. Loehler, R. S. Blumberg, and H.-D. Volk (2004)
J. Immunol. 173, 2342-2352
 |  Abstract »  |  Full Text »  |  PDF »

The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis.

M. Kono, Y. Mi, Y. Liu, T. Sasaki, M. L. Allende, Y.-P. Wu, T. Yamashita, and R. L. Proia (2004)
J. Biol. Chem. 279, 29367-29373
 |  Abstract »  |  Full Text »  |  PDF »

Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system.

X. Coumoul, W. Li, R.-H. Wang, and C. Deng (2004)
Nucleic Acids Res. 32, e85
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair.

C.-G. Huh, V. M. Factor, A. Sanchez, K. Uchida, E. A. Conner, and S. S. Thorgeirsson (2004)
PNAS 101, 4477-4482
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm.

K. Kurita, S. M. Burgess, and N. Sakai (2004)
PNAS 101, 1263-1267
 |  Abstract »  |  Full Text »  |  PDF »

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention.

B. P. Zambrowicz, A. Abuin, R. Ramirez-Solis, L. J. Richter, J. Piggott, H. BeltrandelRio, E. C. Buxton, J. Edwards, R. A. Finch, C. J. Friddle, et al. (2003)
PNAS 100, 14109-14114
 |  Abstract »  |  Full Text »  |  PDF »

Replication and episomal maintenance of Epstein-Barr virus-based vectors in mouse embryonal fibroblasts enable synthetic lethality screens.

Y. Einav, E. Shistik, M. Shenfeld, A. H. Simons, D. W. Melton, and D. Canaani (2003)
Mol. Cancer Ther. 2, 1121-1128
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Live Fry from Intraperitoneally Transplanted Primordial Germ Cells in Rainbow Trout.

Y. Takeuchi, G. Yoshizaki, and T. Takeuchi (2003)
Biol Reprod 69, 1142-1149
 |  Abstract »  |  Full Text »  |  PDF »

A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells.

J.-C. Epinat, S. Arnould, P. Chames, P. Rochaix, D. Desfontaines, C. Puzin, A. Patin, A. Zanghellini, F. Paques, and E. Lacroix (2003)
Nucleic Acids Res. 31, 2952-2962
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter.

T. Shinagawa and S. Ishii (2003)
Genes & Dev. 17, 1340-1345
 |  Abstract »  |  Full Text »  |  PDF »

Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks.

M. H. Porteus, T. Cathomen, M. D. Weitzman, and D. Baltimore (2003)
Mol. Cell. Biol. 23, 3558-3565
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of Protein Kinase C{eta} Results in Impairment of Wound Healing and Enhancement of Tumor Formation in Mouse Skin Carcinogenesis.

K. Chida, T. Hara, T. Hirai, C. Konishi, K. Nakamura, K. Nakao, A. Aiba, M. Katsuki, and T. Kuroki (2003)
Cancer Res. 63, 2404-2408
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric Nucleases Stimulate Gene Targeting in Human Cells.

M. H. Porteus and D. Baltimore (2003)
Science 300, 763
 |  Full Text »  |  PDF »

Enhancing Gene Targeting with Designed Zinc Finger Nucleases.

M. Bibikova, K. Beumer, J. K. Trautman, and D. Carroll (2003)
Science 300, 764
 |  Full Text »  |  PDF »

The Making of "Transgenic Spermatozoa".

C. Celebi, T. Guillaudeux, P. Auvray, V. Vallet-Erdtmann, and B. Jegou (2003)
Biol Reprod 68, 1477-1483
 |  Abstract »  |  Full Text »  |  PDF »

Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides.

M. Dekker, C. Brouwers, and H. te Riele (2003)
Nucleic Acids Res. 31, e27
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Replacement of Mouse Apolipoprotein A-I with Human ApoA-I or the Mutant ApoA-IMilano. EVIDENCE OF APOA-IM IMPAIRED HEPATIC SECRETION.

C. Parolini, G. Chiesa, Y. Zhu, T. Forte, S. Caligari, E. Gianazza, M. G. Sacco, C. R. Sirtori, and E. M. Rubin (2003)
J. Biol. Chem. 278, 4740-4746
 |  Abstract »  |  Full Text »  |  PDF »

Knockout Targeting of the Drosophila Nap1 Gene and Examination of DNA Repair Tracts in the Recombination Products.

S. Lankenau, T. Barnickel, J. Marhold, F. Lyko, B. M. Mechler, and D.-H. Lankenau (2003)
Genetics 163, 611-623
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Disruption of the Murine zyxin Gene.

L. M. Hoffman, D. A. Nix, B. Benson, R. Boot-Hanford, E. Gustafsson, C. Jamora, A. S. Menzies, K. L. Goh, C. C. Jensen, F. B. Gertler, et al. (2003)
Mol. Cell. Biol. 23, 70-79
 |  Abstract »  |  Full Text »

Mouse gene targeting in cardiovascular physiology.

H. Ehmke (2003)
Am J Physiol Regulatory Integrative Comp Physiol 284, R28-R30
 |  Full Text »  |  PDF »

Site-directed recombination via bifunctional PNA-DNA conjugates.

F. A. Rogers, K. M. Vasquez, M. Egholm, and P. M. Glazer (2002)
PNAS 99, 16695-16700
 |  Abstract »  |  Full Text »  |  PDF »

The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland.

C. Vorbach, A. Scriven, and M. R. Capecchi (2002)
Genes & Dev. 16, 3223-3235
 |  Abstract »  |  Full Text »  |  PDF »

Tools for targeted manipulation of the mouse genome.

L. van der Weyden, D. J. Adams, and A. Bradley (2002)
Physiol Genomics 11, 133-164
 |  Abstract »  |  Full Text »  |  PDF »

A chromosomal position effect on gene targeting in human cells.

R. J. Yanez and A. C. G. Porter (2002)
Nucleic Acids Res. 30, 4892-4901
 |  Abstract »  |  Full Text »  |  PDF »

Production of maternal-zygotic mutant zebrafish by germ-line replacement.

B. Ciruna, G. Weidinger, H. Knaut, B. Thisse, C. Thisse, E. Raz, and A. F. Schier (2002)
PNAS 99, 14919-14924
 |  Abstract »  |  Full Text »  |  PDF »

Target-Selected Inactivation of the Zebrafish rag1 Gene.

E. Wienholds, S. Schulte-Merker, B. Walderich, and R. H. A. Plasterk (2002)
Science 297, 99-102
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases.

M. Bibikova, M. Golic, K. G. Golic, and D. Carroll (2002)
Genetics 161, 1169-1175
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian germ-line transgenesis by transposition.

A. J. Dupuy, K. Clark, C. M. Carlson, S. Fritz, A. E. Davidson, K. M. Markley, K. Finley, C. F. Fletcher, S. C. Ekker, P. B. Hackett, et al. (2002)
PNAS 99, 4495-4499
 |  Abstract »  |  Full Text »  |  PDF »

Gene Repair and Transposon-Mediated Gene Therapy.

P. D. Richardson, L. B. Augustin, B. T. Kren, and C. J. Steer (2002)
Stem Cells 20, 105-118
 |  Abstract »  |  Full Text »  |  PDF »

The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye.

S. H. Mui, R. Hindges, D. D. M. O'Leary, G. Lemke, and S. Bertuzzi (2002)
Development 129, 797-804
 |  Abstract »  |  Full Text »  |  PDF »

Use of Genetically Engineered Mice in Drug Discovery and Development: Wielding Occam's Razor to Prune the Product Portfolio.

B. Bolon and E. Galbreath (2002)
International Journal of Toxicology 21, 55-64
 |  Abstract »  |  PDF »

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity.

M. Rios, G. Fan, C. Fekete, J. Kelly, B. Bates, R. Kuehn, R. M. Lechan, and R. Jaenisch (2001)
Mol. Endocrinol. 15, 1748-1757
 |  Abstract »  |  Full Text »  |  PDF »

p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment.

J. Ko, S. Humbert, R. T. Bronson, S. Takahashi, A. B. Kulkarni, E. Li, and L.-H. Tsai (2001)
J. Neurosci. 21, 6758-6771
 |  Abstract »  |  Full Text »  |  PDF »

Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice.

K. Horie, A. Kuroiwa, M. Ikawa, M. Okabe, G. Kondoh, Y. Matsuda, and J. Takeda (2001)
PNAS 98, 9191-9196
 |  Abstract »  |  Full Text »  |  PDF »

Site-Specific Genomic Integration in Mammalian Cells Mediated by Phage {phi}C31 Integrase.

B. Thyagarajan, E. C. Olivares, R. P. Hollis, D. S. Ginsburg, and M. P. Calos (2001)
Mol. Cell. Biol. 21, 3926-3934
 |  Abstract »  |  Full Text »

Gelatinase B functions as regulator and effector in leukocyte biology.

G. Opdenakker, P. E. Van den Steen, B. Dubois, I. Nelissen, E. Van Coillie, S. Masure, P. Proost, and J. Van Damme (2001)
J. Leukoc. Biol. 69, 851-859
 |  Abstract »  |  Full Text »  |  PDF »

Synthetic Hydrogels as Carriers in Antisense Therapy: Preliminary Evaluation of an Oligodeoxynucleotide Covalent Conjugate with a Copolymer of 1-Vinyl-2-Pyrrolidinone and 2-Hydroxyethyl Methacrylate.

X. Lou, K. L. Garrett, P. E. Rakoczy, and T. V. Chirila (2001)
J Biomater Appl 15, 307-320
 |  Abstract »  |  PDF »

Distinct roles for the N- and C-terminal regions in the cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from cabbage butterfly, against mammalian cells.

T. Kanazawa, M. Watanabe, Y. Matsushima-Hibiya, T. Kono, N. Tanaka, K. Koyama, T. Sugimura, and K. Wakabayashi (2001)
PNAS 98, 2226-2231
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases.

M. Bibikova, D. Carroll, D. J. Segal, J. K. Trautman, J. Smith, Y.-G. Kim, and S. Chandrasegaran (2001)
Mol. Cell. Biol. 21, 289-297
 |  Abstract »  |  Full Text »

Transgenic Mice: An Irreplaceable Tool for the Study of Mammalian Development and Biology.

C. BABINET (2000)
J. Am. Soc. Nephrol. 11, S88-S94
 |  Abstract »  |  Full Text »  |  PDF »

Lessons from Loricrin-deficient Mice: Compensatory Mechanisms Maintaining Skin Barrier Function in the Absence of a Major Cornified Envelope Protein.

P. J. Koch, P. A. de Viragh, E. Scharer, D. Bundman, M. A. Longley, J. Bickenbach, Y. Kawachi, Y. Suga, Z. Zhou, M. Huber, et al. (2000)
J. Cell Biol. 151, 389-400
 |  Abstract »  |  Full Text »  |  PDF »

Proliferation, But Not Growth, Blocked by Conditional Deletion of 40S Ribosomal Protein S6.

S. Volarevic, M. J. Stewart, B. Ledermann, F. Zilberman, L. Terracciano, E. Montini, M. Grompe, S. C. Kozma, and G. Thomas (2000)
Science 288, 2045-2047
 |  Abstract »  |  Full Text »

Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway.

Y. T. Kwon, S. A. Balogh, I. V. Davydov, A. S. Kashina, J. K. Yoon, Y. Xie, A. Gaur, L. Hyde, V. H. Denenberg, and A. Varshavsky (2000)
Mol. Cell. Biol. 20, 4135-4148
 |  Abstract »  |  Full Text »

Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides.

T. A. Rando, M.-H. Disatnik, and L. Z.-H. Zhou (2000)
PNAS 97, 5363-5368
 |  Abstract »  |  Full Text »  |  PDF »

Normal Spermatogenesis in Mice Lacking the Testis-Specific Linker Histone H1t.

Q. Lin, A. Sirotkin, and A. I. Skoultchi (2000)
Mol. Cell. Biol. 20, 2122-2128
 |  Abstract »  |  Full Text »

Normal Development, Wound Healing, and Adenovirus Susceptibility in beta 5-Deficient Mice.

X. Huang, M. Griffiths, J. Wu, R. V. Farese Jr., and D. Sheppard (2000)
Mol. Cell. Biol. 20, 755-759
 |  Abstract »  |  Full Text »

5-Lipoxygenase and Leukotrienes . Transgenic Mouse and Nuclear Targeting Studies.

C. D. FUNK and X.-S. CHEN (2000)
Am. J. Respir. Crit. Care Med. 161, S120-124
 |  Full Text »  |  PDF »

Severely Reduced Female Fertility in CD9-Deficient Mice.

F. Le Naour, E. Rubinstein, C. Jasmin, M. Prenant, and C. Boucheix (2000)
Science 287, 319-321
 |  Abstract »  |  Full Text »

Mice cloned from embryonic stem cells.

T. Wakayama, I. Rodriguez, A. C. F. Perry, R. Yanagimachi, and P. Mombaerts (1999)
PNAS 96, 14984-14989
 |  Abstract »  |  Full Text »  |  PDF »

Glycoprotein V-Deficient Platelets Have Undiminished Thrombin Responsiveness and Do Not Exhibit a Bernard-Soulier Phenotype.

M. L. Kahn, T. G. Diacovo, D. F. Bainton, F. Lanza, J. Trejo, and S. R. Coughlin (1999)
Blood 94, 4112-4121
 |  Abstract »  |  Full Text »  |  PDF »

Cerebellar Granule Cell-Specific and Inducible Expression of Cre Recombinase in the Mouse.

M. Tsujita, H. Mori, M. Watanabe, M. Suzuki, J.-i. Miyazaki, and M. Mishina (1999)
J. Neurosci. 19, 10318-10323
 |  Abstract »  |  Full Text »  |  PDF »

The homeodomain protein Vax1 is required for axon guidance and major tract formation in the developing forebrain.

S. Bertuzzi, R. Hindges, S. H. Mui, D. D.M. O'Leary, and G. Lemke (1999)
Genes & Dev. 13, 3092-3105
 |  Abstract »  |  Full Text »

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice.

G. Pagès, S. Guérin, D. Grall, F. Bonino, A. Smith, F. Anjuere, P. Auberger, and J. Pouysségur (1999)
Science 286, 1374-1377
 |  Abstract »  |  Full Text »

Hunting with Traps: Genome-Wide Strategies for Gene Discovery and Functional Analysis.

K. Durick, J. Mendlein, and K. G. Xanthopoulos (1999)
Genome Res. 9, 1019-1025
 |  Abstract »  |  Full Text »

Oxymetholone: II. Evaluation in the Tg.AC Transgenic Mouse Model for Detection of Carcinogens.

H. E. Holden, R. E. Stoll, and K. T. Blanchard (1999)
Toxicol Pathol 27, 507-512
 |  Abstract »  |  PDF »

A vital role for glycosphingolipid synthesis during development and differentiation.

T. Yamashita, R. Wada, T. Sasaki, C. Deng, U. Bierfreund, K. Sandhoff, and R. L. Proia (1999)
PNAS 96, 9142-9147
 |  Abstract »  |  Full Text »  |  PDF »

Ablation of a specific cell population by the replacement of a uniquely expressed gene with a toxin gene.

K. Arase, K. Saijo, H. Watanabe, A. Konno, H. Arase, and T. Saito (1999)
PNAS 96, 9264-9268
 |  Abstract »  |  Full Text »  |  PDF »

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects.

K. A. Sheikh, J. Sun, Y. Liu, H. Kawai, T. O. Crawford, R. L. Proia, J. W. Griffin, and R. L. Schnaar (1999)
PNAS 96, 7532-7537
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Correction of an Episomal Gene in Mammalian Cells by a Short DNA Fragment Tethered to a Triplex-forming Oligonucleotide.

P. P. Chan, M. Lin, A. F. Faruqi, J. Powell, M. M. Seidman, and P. M. Glazer (1999)
J. Biol. Chem. 274, 11541-11548
 |  Abstract »  |  Full Text »  |  PDF »

The LDL Receptor Gene Family, Apolipoprotein B and Cholesterol in Embryonic Development.

J. Herz and R. V. Farese Jr (1999)
J. Nutr. 129, 473
 |  Abstract »  |  Full Text »  |  PDF »

Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.

F. Chen and M. R. Capecchi (1999)
PNAS 96, 541-546
 |  Abstract »  |  Full Text »  |  PDF »

PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse.

K. Grako, T Ochiya, D Barritt, A Nishiyama, and W. Stallcup (1999)
J. Cell Sci. 112, 905-915
 |  Abstract »  |  PDF »

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract.

M. Dottori, L. Hartley, M. Galea, G. Paxinos, M. Polizzotto, T. Kilpatrick, P. F. Bartlett, M. Murphy, F. Kontgen, and A. W. Boyd (1998)
PNAS 95, 13248-13253
 |  Abstract »  |  Full Text »  |  PDF »

Rare Homologous Gene Targeting in Histoplasma capsulatum: Disruption of the URA5Hc Gene by Allelic Replacement.

J. P. Woods, D. M. Retallack, E. L. Heinecke, and W. E. Goldman (1998)
J. Bacteriol. 180, 5135-5143
 |  Abstract »  |  Full Text »

Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior.

M. R. PICCIOTTO and K. WICKMAN (1998)
Physiol Rev 78, 1131-1163
 |  Abstract »  |  Full Text »  |  PDF »

Versican Expression Is Associated With Chamber Specification, Septation, and Valvulogenesis in the Developing Mouse Heart.

D. J. Henderson and A. J. Copp (1998)
Circ. Res. 83, 523-532
 |  Abstract »  |  Full Text »  |  PDF »

Embryonic Stem Cells with a Disrupted GD3 Synthase Gene Undergo Neuronal Differentiation in the Absence of b-Series Gangliosides.

H. Kawai, K. Sango, K. A. Mullin, and R. L. Proia (1998)
J. Biol. Chem. 273, 19634-19638
 |  Abstract »  |  Full Text »  |  PDF »

Functional Genomics in the Mouse: Phenotype-Based Mutagenesis Screens.

J. Schimenti and M. Bucan (1998)
Genome Res. 8, 698-710
 |  Abstract »  |  Full Text »

Two Kinesin Light Chain Genes in Mice. IDENTIFICATION AND CHARACTERIZATION OF THE ENCODED PROTEINS.

A. Rahman, D. S. Friedman, and L. S. B. Goldstein (1998)
J. Biol. Chem. 273, 15395-15403
 |  Abstract »  |  Full Text »  |  PDF »

Defective Motor Behavior and Neural Gene Expression in RIIbeta -Protein Kinase A Mutant Mice.

E. P. Brandon, S. F. Logue, M. R. Adams, M. Qi, S. P. Sullivan, A. M. Matsumoto, D. M. Dorsa, J. M. Wehner, G. S. McKnight, and R. L. Idzerda (1998)
J. Neurosci. 18, 3639-3649
 |  Abstract »  |  Full Text »  |  PDF »

T and B Cell Development in BP-1/6C3/Aminopeptidase A-Deficient Mice.

Q. Lin, I. Taniuchi, D. Kitamura, J. Wang, J. F. Kearney, T. Watanabe, and M. D. Cooper (1998)
J. Immunol. 160, 4681-4687
 |  Abstract »  |  Full Text »  |  PDF »

Genomic Organization of Drosophila Poly(ADP-ribose) Polymerase and Distribution of Its mRNA during Development.

S. Hanai, M. Uchida, S. Kobayashi, M. Miwa, and K. Uchida (1998)
J. Biol. Chem. 273, 11881-11886
 |  Abstract »  |  Full Text »  |  PDF »

Modification of bacterial artificial chromosomes through Chi-stimulated homologous recombination and its application in zebrafish transgenesis.

J. R. Jessen, A. Meng, R. J. McFarlane, B. H. Paw, L. I. Zon, G. R. Smith, and S. Lin (1998)
PNAS 95, 5121-5126
 |  Abstract »  |  Full Text »  |  PDF »

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