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Science 9 June 1989:
Vol. 244. no. 4909, pp. 1184 - 1186
DOI: 10.1126/science.2658061
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Articles

Science, Vol 244, Issue 4909, 1184-1186
Copyright © 1989 by American Association for the Advancement of Science

articles

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum

CM Wilson, AE Serrano, A Wasley, MP Bogenschutz, AH Shankar, and DF Wirth

Department of Tropical Public Health Harvard School of Public Health, Boston, MA 02115.

The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Association of pfcrt But Not pfmdr1 Alleles with Chloroquine Resistance in Iranian Isolates of Plasmodium falciparum.
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Drug-Regulated Expression of Plasmodium falciparum P-Glycoprotein Homologue 1: a Putative Role for Nuclear Receptors.
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Recurrent Gene Amplification and Soft Selective Sweeps during Evolution of Multidrug Resistance in Malaria Parasites.
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A Molecular Marker for Chloroquine-Resistant Falciparum Malaria.
A. Djimde, O. K. Doumbo, J. F. Cortese, K. Kayentao, S. Doumbo, Y. Diourte, A. Dicko, X.-z. Su, T. Nomura, D. A. Fidock, et al. (2001)
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ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium.
D. T. Brazill, L. R. Meyer, R. D. Hatton, D. A. Brock, and R. H. Gomer (2001)
J. Cell Sci. 114, 3923-3932
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Role of P Glycoprotein in the Course and Treatment of Encephalitozoon Microsporidiosis.
G. J. Leitch, M. Scanlon, A. Shaw, and G. S. Visvesvara (2001)
Antimicrob. Agents Chemother. 45, 73-78
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Role of the Neurotransmitter Reuptake-Blocking Activity of Antidepressants in Reversing Chloroquine Resistance In Vitro in Plasmodium falciparum.
D. Taylor, J. C. Walden, A. H. Robins, and P. J. Smith (2000)
Antimicrob. Agents Chemother. 44, 2689-2692
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The pfmdr1 Gene Is Associated with a Multidrug-Resistant Phenotype in Plasmodium falciparum from the Western Border of Thailand.
R. N. Price, C. Cassar, A. Brockman, M. Duraisingh, M. van Vugt, N. J. White, F. Nosten, and S. Krishna (1999)
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Cyclosporin Analogs Inhibit In Vitro Growth of Cryptosporidium parvum.
M. E. Perkins, T. W. Wu, and S. M. Le Blancq (1998)
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Variations in frequencies of drug resistance in Plasmodium falciparum.
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Detection of RAPD Markers Correlated with Chloroquine Resistance in Plasmodium falciparum.
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Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes.
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