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Science 9 June 1989:
Vol. 244. no. 4909, pp. 1179 - 1183
DOI: 10.1126/science.2499048
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Articles

Science, Vol 244, Issue 4909, 1179-1183
Copyright © 1989 by American Association for the Advancement of Science

articles

Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant

J Bohme, K Haskins, P Stecha, W van Ewijk, M LeMeur, P Gerlinger, C Benoist, and D Mathis

Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS--Unite 184, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France.

Insulin-dependent diabetes mellitus (IDDM) is caused by a specific loss of the insulin-producing beta cells from pancreatic Langerhans islets. It has been proposed that aberrant expression of major histocompatibility complex (MHC) class II molecules on these cells could be a triggering factor for their autoimmune destruction. This proposal was tested in transgenic mice that express allogeneic or syngeneic class II molecules on the surface of islet cells at a level comparable with that normally found on resting B lymphocytes. These animals do not develop diabetes, nor is lymphocyte infiltration of the islets observed. This immunological inactivity does not result from tolerance to the "foreign" class II molecules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transgenic Mice Producing Major Histocompatibility Complex Class II Molecules on Thyroid Cells Do Not Develop Apparent Autoimmune Thyroid Diseases.
Y.-S. Li, N. Kanamoto, Y. Hataya, K. Moriyama, H. Hiratani, K. Nakao, and T. Akamizu (2004)
Endocrinology 145, 2524-2530
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Vigorous Allograft Rejection in the Absence of Danger.
A. W. Bingaman, J. Ha, S.-Y. Waitze, M. M. Durham, H. R. Cho, C. Tucker-Burden, R. Hendrix, S. R. Cowan, T. C. Pearson, and C. P. Larsen (2000)
J. Immunol. 164, 3065-3071
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Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire.
O. S. Targoni and P. V. Lehmann (1998)
J. Exp. Med. 187, 2055-2063
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Peripheral clonal elimination of functional T cells.
L. Jones, L. Chin, D. Longo, and A. Kruisbeek (1990)
Science 250, 1726-1729
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T cell reactivity to MHC molecules: immunity versus tolerance.
J Sprent, E. Gao, and S. Webb (1990)
Science 248, 1357-1363
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Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells.
L. Burkly, D Lo, and R. Flavell (1990)
Science 248, 1364-1368
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Transgenic mice as probes into complex systems.
D Hanahan (1989)
Science 246, 1265-1275
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