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Science 2 June 1989:
Vol. 244. no. 4908, pp. 1087 - 1088
DOI: 10.1126/science.2543077
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Articles

Science, Vol 244, Issue 4908, 1087-1088
Copyright © 1989 by American Association for the Advancement of Science

articles

Two NF1 translocations map within a 600-kilobase segment of 17q11.2

P O'Connell, R Leach, RM Cawthon, M Culver, J Stevens, D Viskochil, RE Fournier, DC Rich, DH Ledbetter, and R White

Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132.

Balanced translocations, each involving chromosome 17q11.2, have been described in two patients with von Recklinghausen neurofibromatosis (NF1). To better localize the end points of these translocation events, and the NF1 gene (NF1) itself, human cosmids were isolated and mapped in the immediate vicinity of NF1. One cosmid probe, c11-1F10, demonstrated that both translocation breakpoints, and presumably NF1, are contained within a 600-kilobase Nru I fragment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.
M. Wallace, D. Marchuk, L. Andersen, R Letcher, H. Odeh, A. Saulino, J. Fountain, A Brereton, J Nicholson, A. Mitchell, et al. (1990)
Science 249, 181-186
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Neurofibromatosis 1 (Recklinghausen Disease) and Neurofibromatosis 2 (Bilateral Acoustic Neurofibromatosis) An Update.
J. J. Mulvihill, D. M. Parry, J. L. Sherman, A. Pikus, M. I. Kaiser-Kupfer, and R. Eldridge (1990)
Ann Intern Med 113, 39-52
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