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Science 2 June 1989:
Vol. 244. no. 4908, pp. 1078 - 1081
DOI: 10.1126/science.2524877
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Articles

Science, Vol 244, Issue 4908, 1078-1081
Copyright © 1989 by American Association for the Advancement of Science

articles

Sporozoite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes

SL Hoffman, D Isenbarger, GW Long, M Sedegah, A Szarfman, L Waters, MR Hollingdale, PH van der Meide, DS Finbloom, and WR Ballou

Infectious Diseases Department, Naval Medical Research Institute, Bethesda, MD 20814.

The target of the CD8+ T cell-dependent immunity that protects mice immunized with irradiation-attenuated malaria sporozoites has not been established. Immune BALB/c mice were shown to develop malaria-specific, CD8+ T cell-dependent inflammatory infiltrates in their livers after challenge with Plasmodium berghei sporozoites. Spleen cells from immune BALB/c and C57BL/6 mice eliminated hepatocytes infected with the liver stage of P. berghei in vitro. The activity against infected hepatocytes is not inhibited by antibodies to interferon-gamma and is not present in culture supernatants. It is genetically restricted, an indication that malaria antigens on the hepatocyte surface are recognized by immune T effector cells. Subunit vaccine development will require identification of the antigens recognized by these T cells and a method of immunization that induces such immunity.


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