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Science 2 June 1989:
Vol. 244. no. 4908, pp. 1063 - 1064
DOI: 10.1126/science.2727694
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Articles

Science, Vol 244, Issue 4908, 1063-1064
Copyright © 1989 by American Association for the Advancement of Science

articles

Images of the DNA double helix in water

SM Lindsay, T Thundat, L Nagahara, U Knipping, and RL Rill

Department of Physics, Arizona State University, Tempe 85287.

The scanning tunneling microscope can image uncoated DNA submerged in water. The grooves of the double helix were clearly resolved in images of the 146-base pair fragment extracted from calf thymus nucleosome. In contrast to images obtained with dry DNA, the helix pitch varied only a small amount (36 +/- 5 angstroms). The path of the helix shows considerable variation. It is quite straight when the molecules are densely packed, but it curves and bends in isolated molecules.


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