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Science 26 May 1989:
Vol. 244. no. 4907, pp. 983 - 985
DOI: 10.1126/science.2543073
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Articles

Science, Vol 244, Issue 4907, 983-985
Copyright © 1989 by American Association for the Advancement of Science

articles

Autonomic regulation of a chloride current in heart

RD Harvey and Hume JR

Department of Physiology, University of Nevada School of Medicine, Reno 89557.

In isolated heart cells, beta-adrenergic receptor stimulation induced a background current that was suppressed by simultaneous muscarinic receptor stimulation. Direct activation of adenylate cyclase with forskolin also elicited this current, suggesting regulation by adenosine 3',5'-monophosphate (cAMP). This current could be recorded when sodium, calcium, and potassium currents were eliminated by channel antagonists or by ion substitution. Alteration of the chloride equilibrium potential produced changes in the reversal potential expected for a chloride current. Activation of this chloride current modulated action potential duration and altered the resting membrane potential in a chloride gradient-dependent manner.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)