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Science 26 May 1989:
Vol. 244. no. 4907, pp. 980 - 983
DOI: 10.1126/science.2543072
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Articles

Science, Vol 244, Issue 4907, 980-983
Copyright © 1989 by American Association for the Advancement of Science

articles

A pertussis toxin-sensitive G protein in hippocampal long-term potentiation

JW Goh and PS Pennefather

Faculty of Pharmacy, University of Toronto, Ontario, Canada.

High-frequency (tetanic) stimulation of presynaptic nerve tracts in the hippocampal region of the brain can lead to long-term synaptic potentiation (LTP). Pertussis toxin prevented the development of tetanus-induced LTP in the stratum radiatum-CA1 synaptic system of rat hippocampal slices, indicating that a guanosine triphosphate-binding protein (G protein) may be required for the initiation of LTP. This G protein may be located at a site distinct from the postsynaptic neuron (that is, in presynaptic terminals or glial cells) since maximal activation of CA1 neuronal G proteins by intracellular injection of guanosine-5'-O-(3-thiotriphosphate), a nonhydrolyzable analog of guanosine 5'-triphosphate, did not occlude LTP.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Kindling Epileptogenesis by Hippocampal Galanin Type 1 and Type 2 Receptors: The Effects of Subtype-Selective Agonists and the Role of G-Protein-Mediated Signaling.
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Group I Metabotropic Glutamate Receptor Signaling via Galpha q/Galpha 11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA1.
M. Miura, M. Watanabe, S. Offermanns, M. I. Simon, and M. Kano (2002)
J. Neurosci. 22, 8379-8390
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Role of Pertussis Toxin-Sensitive G-Proteins in Synaptic Transmission and Plasticity at Corticostriatal Synapses.
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J Neurophysiol 83, 60-69
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Regulation and Immunohistochemical Localization of beta gamma -Stimulated Adenylyl Cyclases in Mouse Hippocampus.
L. P. Baker, M. D. Nielsen, S. Impey, B. M. Hacker, S. W. Poser, M. Y. M. Chan, and D. R. Storm (1999)
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GABAB Receptors, Monoamine Receptors, and Postsynaptic Inositol Trisphosphate-Induced Ca2+ Release Are Involved in the Induction of Long-Term Potentiation at Visual Cortical Inhibitory Synapses.
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A requirement for the intercellular messenger nitric oxide in long-term potentiation.
E. Schuman and D. Madison (1991)
Science 254, 1503-1506
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Diversity of G proteins in signal transduction.
M. Simon, M. Strathmann, and N Gautam (1991)
Science 252, 802-808
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Science. ISSN 0036-8075 (print), 1095-9203 (online)