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Science 19 May 1989:
Vol. 244. no. 4906, pp. 820 - 822
DOI: 10.1126/science.2471264
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Articles

Science, Vol 244, Issue 4906, 820-822
Copyright © 1989 by American Association for the Advancement of Science

articles

Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells

AW Lohse, F Mor, N Karin, and IR Cohen

Weizmann Institute of Science, Department of Cell Biology, Rehovot, Israel.

T cell vaccination against experimental autoimmune disease is herein shown to be mediated in part by anti-ergotypic T cells, T cells that recognize and respond to the state of activation of other T cells. The anti-ergotypic response thus combines with the previously shown anti-idiotypic T cell response to regulate autoimmunity.


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