Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 May 1989:
Vol. 244. no. 4906, pp. 813 - 817
DOI: 10.1126/science.2471263
Prev | Table of Contents | Next

Articles

Science, Vol 244, Issue 4906, 813-817
Copyright © 1989 by American Association for the Advancement of Science

articles

Transmembrane channels based on tartaric acid-gramicidin A hybrids

CJ Stankovic, SH Heinemann, JM Delfino, FJ Sigworth, and SL Schreiber

The gramicidin A transmembrane channel is believed to consist of two head-to-head beta helices. Computer-generated models were used to formulate the structure of new single-chain channel molecules based on the gramicidin motif. The chemical synthesis of two tartaric acid-gramicidin A hybrids and single-channel analyses of their conducting properties are reported. These studies illustrate the rational design and synthesis of long-lived channels with tunable conductance properties and provide support for current molecular models of the natural (dimeric) gramicidin channel.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Murine Lethal Toxic Shock Caused by Intranasal Administration of Staphylococcal Enterotoxin B.
V. Savransky, V. Rostapshov, D. Pinelis, Y. Polotsky, S. Korolev, J. Komisar, and K. Fegeding (2003)
Toxicol Pathol 31, 373-378
   Abstract »    PDF »
The conducting form of gramicidin A is a right-handed double-stranded double helix.
B. M. Burkhart, N. Li, D. A. Langs, W. A. Pangborn, and W. L. Duax (1998)
PNAS 95, 12950-12955
   Abstract »    Full Text »    PDF »
Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.
P. Golumbek, A. Lazenby, H. Levitsky, L. Jaffee, H Karasuyama, M Baker, and D. Pardoll (1991)
Science 254, 713-716
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)