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Science 19 May 1989:
Vol. 244. no. 4906, pp. 811 - 813
DOI: 10.1126/science.2524876

Articles

Science, Vol 244, Issue 4906, 811-813
Copyright © 1989 by American Association for the Advancement of Science


articles

V beta-specific stimulation of human T cells by staphylococcal toxins

J Kappler, B Kotzin, L Herron, EW Gelfand, RD Bigler, A Boylston, S Carrel, DN Posnett, Y Choi, and P Marrack

Howard Hughes Medical Institute, Denver, CO.

The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular V beta sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for V beta s puts them in the recently described class of superantigens and may account for the differential sensitivity of different individuals to the toxic effects of these proteins.


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