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Science 5 May 1989:
Vol. 244. no. 4904, pp. 572 - 575
DOI: 10.1126/science.2470147
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Articles

Science, Vol 244, Issue 4904, 572-575
Copyright © 1989 by American Association for the Advancement of Science

articles

Murine MHC polymorphism and T cell specificities

S Roy, MT Scherer, TJ Briner, JA Smith, and ML Gefter

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

The major histocompatibility complex (MHC) genes are polymorphic in mouse and man. The products of these genes are receptors for peptides, which while bound, are displayed to T lymphocytes. When bound peptides from antigens are recognized by T lymphocytes, an immune response is initiated against the antigens. This study assessed the relation of the polymorphic MHC molecules to their peptide specificity. The results indicate that although an individual of the species has a limited ability to recognize antigens, the species as a whole has broad reactivity. This rationalizes the extreme polymorphism observed.


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