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Science 5 May 1989:
Vol. 244. no. 4904, pp. 566 - 569
DOI: 10.1126/science.2541502
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Articles

Science, Vol 244, Issue 4904, 566-569
Copyright © 1989 by American Association for the Advancement of Science

articles

AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells

LR Bernstein and NH Colburn

Johns Hopkins University, Department of Biology, Baltimore, MD 21218.

Tumor promoters may bring about events that lead to neoplastic transformation by inducing specific promotion-relevant effector genes. Functional activation of the transacting transcription factor AP-1 by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) may play an essential role in this process. Clonal genetic variants of mouse epidermal JB6 cells that are genetically susceptible (P+) or resistant (P-) to promotion of transformation by TPA were transfected with 3XTRE-CAT, a construct that has AP-1 cis-enhancer sequences attached to a reporter gene encoding chloramphenicol acetyltransferase (CAT). Transfected JB6 P+, but not P- variants, showed TPA-inducible CAT synthesis. Epidermal growth factor, another transformation promoter in JB6 cells, also caused P+ specific induction of CAT gene expression. These results demonstrate an association between induced AP-1 function and sensitivity to promotion of neoplastic transformation.


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