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Science 5 May 1989:
Vol. 244. no. 4904, pp. 546 - 550
DOI: 10.1126/science.2541501
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Articles

Science, Vol 244, Issue 4904, 546-550
Copyright © 1989 by American Association for the Advancement of Science

articles

Studies of inositol phospholipid-specific phospholipase C

SG Rhee, PG Suh, SH Ryu, and SY Lee

Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.

Inositol phospholipid-specific phospholipase C is the enzyme that generates phosphoinositide-derived messenger molecules. Mammalian cells contain at least five immunologically distinct phospholipase C enzymes that appear to be separate gene products. Complete amino acid sequences of four of these isozymes have been established. The overall sequence similarity is surprisingly low for enzymes catalyzing the same chemical reaction: three of them show limited amino acid sequence similarity to each other in two narrow regions, and the fourth enzyme is completely different. The diversity in primary structure together with different regional and cellular expression of the isozymes suggests that each isozyme has a defined function in processing the physiological response of different cell types to a variety of external stimuli and that each is regulated differently.


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